A5059964082- Cancer Cells and Metastasis
- Viral gastroenteritis research and epidemiology
- Glycosylation and Glycoproteins Research
- Animal Virus Infections Studies
- Language Development and Disorders
- Immune Cell Function and Interaction
- Social Sciences and Governance
- Transgenic Plants and Applications
- Corporate Taxation and Avoidance
- Viral Infections and Immunology Research
- Animal Genetics and Reproduction
- Immunotherapy and Immune Responses
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- Oral Health Pathology and Treatment
- Reading and Literacy Development
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Maritime Ports and Logistics
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Coccidia and coccidiosis research
- Trypanosoma species research and implications
- Helminth infection and control
University of Toronto
2022
City University of Hong Kong
2009-2020
Chinese University of Hong Kong
2018-2019
Baylor College of Medicine
2019
Queen's University Belfast
2015-2016
Institute of Biological Chemistry, Academia Sinica
2015
Genomics Research Center, Academia Sinica
2015
National Tsing Hua University
2015
Genomics (United Kingdom)
2013
Academia Sinica
2013
Globo H (GH) is a hexasaccharide specifically overexpressed on variety of cancer cells and therefore, good candidate for vaccine development. To identify the optimal carrier adjuvant combination, we chemically synthesized linked GH to protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reactive material (CRM) 197 (DT), tetanus toxoid, BSA, combined with an adjuvant, it was administered mice study immune response. Glycan microarray analysis antiserum obtained indicated that...
Significance Cancer stem cells are cancer with self-renewal and tumor-growth properties important targets for development of anticancer therapy. We have found breast can be enriched by stage-specific embryonic antigen 3 (SSEA-3) known protein markers (CD24 CD44), as few 10 such develop tumor in mice. Also, the enzyme galactosyltransferase (β3GalT5) biosynthesis SSEA-3 is expressed but not normal cells, both β3GalT5 shown to essential cell survival. These findings led a new strategy proof...
We compared viral load of emerging recombinant norovirus GII.P16-GII.2 with those for pandemic GII.Pe-GII.4 and epidemic GII.P17-GII.17 genotypes among inpatients in Hong Kong. Viral was higher than other different age groups. is as replication competent the genotype, explaining its high transmissibility widespread circulation.
Tools to detect human norovirus infectivity have been lacking. Using intestinal enteroid cultures inoculated with GII.Pe-GII.4 Sydney-infected fecal samples, we determined that a real-time reverse transcription PCR cycle threshold cutoff of 30 may indicate infectious norovirus. This finding could be used help guide infection control.
Background and Purpose NF ‐κ B ‐driven inflammation is negatively regulated by the zinc finger protein A 20. Gibberellic acid ( GA 3 ) a plant‐derived diterpenoid with documented anti‐inflammatory activity, which reported to induce 20‐like proteins in plants. Here, we sought investigate effect of airway epithelial cells determine if action relates 20 induction. Experimental Approach Primary nasal human bronchial cell line (16 HBE 14o‐) were used. Cells pre‐incubated , stimulated P seudomonas...
Tumour metastasis is a complex process that strongly influences the prognosis and treatment of cancer. Apart from intracellular factors, recent studies have indicated also depends on microenvironmental factors such as biochemical, mechanical topographical properties surrounding extracellular matrix (ECM) tumours. In this study, proof concept, we conducted tumour spheroid dissemination assay engineered surfaces with micrograting patterns. Nasopharyngeal spheroids were generated by 3D culture...
Transcription factories have been characterized in cultured mammalian cells, but little is known about the regulation of these nuclear structures different primary cell types. Using marine medaka, we observed transcription sites labeled by metabolic incorporation 5-fluorouridine (5-FU) into nascent RNA. Medaka was permeable to 5-FU ambient water and became fully within 4 hr incubation. The inhibited inhibitor actinomycin D. were detected nucleus, could be abolished RNase digestion. tissue...
Acute hepatopancreatic necrosis disease (AHPND) is a devastating shrimp caused by binary toxin, PirAB, produced Vibrio parahaemolyticus and other closely related bacteria. To address AHPND, over 300 unique single-domain antibodies (also known as nanobodies) derived from the V H domains of Lama glama heavy-chain-only were raised against either PirA or PirB characterized. Nanobodies shortlisted based on their affinities for PirB, relative stability in intestinal fluids, ability to reduce...
The current study examines the self-voice benefit in an early bilingual population. Female Cantonese-English bilinguals produced words containing Cantonese contrasts. A subset of these minimal pairs was selected as stimuli for a perception task. Speakers' productions were grouped according to how acoustically contrastive their pronunciation each pair and groupings used design personalized experiments participant, featuring own voice voices others' similarly-contrastive tokens. task...