A5028390439- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Medical Imaging Techniques and Applications
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Therapeutic Uses of Natural Elements
- Cancer survivorship and care
- Cytokine Signaling Pathways and Interactions
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Histone Deacetylase Inhibitors Research
National University of Rosario
2012-2024
Centro Científico Tecnólogico - Rosario
2023-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2017
Fribourg Development Agency
2004
Background:There is limited literature on the prevalence of EGFR mutations in early-stage non-small cell lung cancer (NSCLC).EARLY-EGFR (NCT04742192), a cross-sectional study, determined NSCLC. Methods:This non-interventional, real-world study enrolled consecutive patients with resected stage IA-IIIB (American Joint Committee Cancer 8 th edition) NSCLC from 14 countries across Asia, Latin America, and Middle East Africa.The primary endpoint was secondary endpoints included mutation subtypes...
TPS847 Background: B7-H3 is an immune checkpoint protein overexpressed in multiple solid tumors with limited expression normal tissues. GSK’227 (HS-20093), a novel B7-H3-targeted ADC, composed of human anti–B7-H3 monoclonal antibody linked to topoisomerase I inhibitor via protease-cleavable linker, and has shown acceptable safety promising antitumor activity patients Asian origin advanced (NCT05276609; NCT05830123). The current study will evaluate the safety, tolerability, efficacy,...
Calciphylaxis, also called calcific uraemic arteriolopathy, is a rare disease characterized by medial calcification of the small arteries and ischaemia subcutaneous tissue, often leading to necrosis fat skin. It affects mainly women with chronic renal insufficiency and/or obesity. According recent studies, calciphylaxis seems occur more frequently than previously believed, an incidence 1% per year [1] prevalence 4% in dialysis patients [2]. The pathogenesis poorly understood its treatment...
Metronomic chemotherapy (MCT), the chronic administration, at regular intervals, of low doses chemotherapeutic drugs without extended rest periods, allows treatment with therapeutic efficacy and toxicity. Our preclinical results suggested that combined MCT cyclophosphamide celecoxib could inhibit breast cancer growth. The aim this study was to determine toxicity, safety oral 50 mg per orem daily 400 (200 two-times a day) in advanced patients. During first stage study, response consisted...
Abstract Background: B7-homolog 3 protein (B7-H3) is an immune checkpoint overexpressed in many types of solid tumors, but with limited expression normal tissues [1]. GSK5764227 (GSK’227) a novel antibody-drug conjugate (ADC) composed fully human anti-B7-H3 monoclonal antibody linked to topoisomerase I inhibitor via protease-cleavable linker. GSK’227 (also known as HS-20093) has shown acceptable safety and promising antitumor activity Asian patients advanced tumors (NCT05276609;...
Abstract Background Gallstone disease ( GD ) incidence and prevalence rates differ between populations. Diet lifestyle may be involved in development. To our knowledge, no study to date has evaluated quantitative data on diet when studying the relationship fat consumption levels an Argentinean population. The present aimed assess association dietary intake . Methods A nested case–control design was applied. Data were taken from subjects who participated a previous cross‐sectional carried out...
Aim: The objective of the study was to detect changes in quality life (QoL) metastatic breast cancer patients treated with metronomic chemotherapy daily low doses cyclophosphamide and celecoxib. Material & methods: Patients included a Phase II trial, celecoxib were QoL study. Assessment carried out every 2 months by Functional Cancer Therapy Breast (FACT-B) questionnaire, Brief Pain Inventory Eastern Cooperative Oncologic Group scale. Data analyzed at three time points: baseline (BL); middle...
Ovarian cancer (OC) is the leading cause of death from gynaecological cancer.It extremely hard to diagnose in early stages and around 70% patients present with advanced disease.Metronomic chemotherapy (MCT) described as chronic administration of, generally low, equally spaced, doses chemotherapeutic drugs therapeutic efficacy low toxicity.This an effective low-cost way treat several types tumours, including ovarian cancer.Here, we six cases treated MCT cyclophosphamide, which showed clinical...
Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for treatment murine mammary tumors. The aim this study was compare their effects on tumor and metastasis growth, survival, toxicity. with Cyclophosphamide + Celecoxib (Cy Cel) showed higher antimetastatic power than Doxorubicin Dox), while being similar in other aspects. That difference, plus...
Identifying tumor biomarkers associated with clinical behavior in breast cancer patients may allow higher accuracy the selection of treatment. Different types cells were determined primary tumors stage I, II, and III patients, who assigned to one two groups: (1) disease-free or (2) relapsed/progressed, at 5 years after We studied 32 samples. CD4+ lymphocytes CD44+CD24-/low (cancer stem cells) showed a significant association outcome treatment, while CD8+, Foxp3+, CD34+, myeloid-derived...
Nutritional exposure is considered the main environmental influence that contributes to gallstone disease (GD).
e12629 Background: Little is known about the timing-related effects of interval between last neoadjuvant CT administration and surgery (CTTS) in patients (pts) with early breast cancer (BC). Methods: The NeoBracer study analyzed a cohort 683 consecutive BC pts treated 7 Centers (4 Italy, 1 Argentina, Mexico Romania), 2004 2015. Cox regression was performed to evaluate prognostic impact CTTS terms relapse free survival (RFS) overall (OS). best cut-off explored through median ROC analysis....
Abstract The efficacy and low toxicity of antiangiogenic metronomic chemotherapy (MCT) with cyclophosphamide (Cy) celecoxib (Cel) in advanced breast cancer patients (ABCP) was demonstrated our studies but no reliable biomarkers or predictors response have been found yet. aim this study to analyze several pro- anti-angiogenic parameters evaluate their potential role as predictor duration ABCP treated MCT daily Cy Cel. Treatment plan: Patients received 50 mg p.o./day + Cel 200 p.o. bid. This...
Abstract Metronomic chemotherapy (MCT) refers to the chronic, equally spaced, delivery of low doses different chemotherapeutic drugs, without extended interruptions. We have already demonstrated that MCT, as an intervention strategy, metronomic Cy combined with celecoxib or doxorubicin inhibits mammary tumors growth. Our present aim was analyze antitumor and antimetastatic effects MCT Met. Inbred CBi mice were s.c. i.v. challenged M-406 tumor (Day 0), treated when reached a volume 100 150...
e13500 Background: The oral administration of Cyclophosphamide (Cy) and Celecoxib (Cel) encourage the use low-dose metronomic chemotherapy (MC) to treat heavily pretreated, multidrug resistant, advanced breast cancer patients (ABCP). Methods: Study design: Single arm, mono-institutional, nonrandomized, phase II, two steps clinical trial (Approved by Bioethics Committee #5732/2007 ANMAT-Argentine Regulatory Authority- #4596/09). 15 were enrolled in first stage, 5 additional second one (β...
Abstract Metronomic chemotherapy (MCT) refers to the chronic, equally spaced, delivery of low doses different chemotherapeutic drugs, without extended interruptions. We have developed two combined MCT schemes for treatment mammary tumors: A) cyclophosphamide (Cy) 30 mg/kg/day p.o. + celecoxib (Cel) mg/kg 5 times/week, and B) Cy 20 doxorubicin (Dox) 0.5 mg/kg, 3 times/week i.p. They were tested in experimental models adenocarcinomas: I) M-406 II) M-234p syngeneic with inbred CBi BALB/c mice,...