A5062749001- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Toxoplasma gondii Research Studies
- Helminth infection and control
- Cytomegalovirus and herpesvirus research
- Coral and Marine Ecosystems Studies
- Histone Deacetylase Inhibitors Research
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Invertebrate Immune Response Mechanisms
- Research on Leishmaniasis Studies
- Marine Sponges and Natural Products
- Protist diversity and phylogeny
- Trypanosoma species research and implications
- Fungal Biology and Applications
- Animal and Plant Science Education
- Plant Pathogens and Fungal Diseases
- Leech Biology and Applications
- Plant and Fungal Species Descriptions
- Epigenetics and DNA Methylation
- Mosquito-borne diseases and control
- Aquaculture disease management and microbiota
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
Université de Lille
2011-2024
Centre National de la Recherche Scientifique
2007-2024
Institut Pasteur de Lille
2009-2024
Inserm
2009-2024
Centre Hospitalier Universitaire de Lille
2017-2024
Center for Infection and Immunity of Lille
2013-2024
Université de Montpellier
2017
Université de Perpignan
2004-2017
Ifremer
2017
Université Lille Nord de France
2009-2011
Abstract Background Coral bleaching can be defined as the loss of symbiotic zooxanthellae and/or their photosynthetic pigments from cnidarian host. This major disturbance reef ecosystems is principally induced by increases in water temperature. Since beginning 1980s and onset global climate change, this phenomenon has been occurring at increasing rates scales, with severity. Several studies have undertaken last few years to better understand cellular molecular mechanisms coral but jigsaw...
Invertebrates were long thought to possess only a simple, effective and hence non-adaptive defence system against microbial parasitic attacks. However, recent studies have shown that invertebrate immunity also relies on immune receptors diversify (e.g. in echinoderms, insects mollusks (Biomphalaria glabrata)). Apparently, individual or population-based polymorphism-generating mechanisms exists permit the survival of species exposed parasites. Consequently, generally accepted arms race...
Apicomplexan parasites have evolved efficient and distinctive strategies for intracellular replication where the timing of emergence daughter cells (budding) is a decisive element. However, molecular mechanisms that provide proper parasite budding remain unknown. Using Toxoplasma gondii as model Apicomplexan, we identified master regulator controls process. We show an ApiAP2 transcription factor, TgAP2IX-5, cell cycle events downstream centrosome duplication. TgAP2IX-5 binds to promoter...
In recent decades, numerous studies have sought to better understand the mechanisms underlying compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, genomics, interactomics more targeted approaches enabled researchers identify a series candidate genes. However, no molecular work has yet been performed on multiple populations displaying different levels compatibility. Here, we seek fill this gap in literature. We focused B. FREPs...
We report here the screening of five marine invertebrate species from two taxa (tunicates and echinoderms) for presence cationic antimicrobial peptides (AMP) in defence cells (hemocytes). Antimicrobial activities were detected only tunicates Microcosmus sabatieri Halocynthia papillosa. In addition, we isolation characterization novel H. papillosa hemocytes. These molecules display antibacterial activity against Gram-positive Gram-negative bacteria. Complete peptide was obtained by a...
Abstract The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in dynamics interaction between its gut symbiont . By combining biochemical molecular approaches, isolated identified for first time antimicrobial peptides (AMPs) produced by digestive tract Immunohistochemistry data PCR analyses...
Toxoplasma gondii is a eukaryotic parasite that forms latent cysts in the brain of immunocompetent individuals. The infection immune-privileged central nervous system linked to most complications. With no drug currently available eliminate infected hosts, consequences neurons' long-term are unknown. It has long been known T. specifically differentiates into form (bradyzoite) neurons, but how neuron responds remains be elucidated. We have established new vitro model resulting production...
Only one drug is currently available for the treatment and control of schistosomiasis increasing risk selecting strains schistosome that are resistant to praziquantel means development new drugs urgent. With this objective we have chosen target enzymes modifying histones in particular histone acetyltransferases deacetylases (HDAC). Inhibitors HDACs (HDACi) under intense study as potential anti-cancer act via induction cell cycle arrest and/or apoptosis. Schistosomes like other parasites can...
The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. strains can infect efficiently only certain B. (compatible strain) while others are incompatible. Strain-specific differences in transcription of conserved family polymorphic mucins (SmPoMucs) principle determinants for this compatibility. In present study, we investigated bases control SmPoMuc expression evolved to evade diversified antigen...
Epigenetics, the science of heritable but modifiable information, is now a well-accepted component many research fields. Nevertheless, epigenetics has not yet found broad appreciation in one most exciting fields biology: comprehension evolution. This surprising, since reason for existence this alternative information-transmitting system lies certainly evolutionary advantage it provides. Theoretical considerations support model which epigenetic mechanisms allow increasing phenotypic...
ABSTRACT Toxoplasmosis is a critical health issue for immune-deficient individuals and the offspring of newly infected mothers. It caused by unicellular intracellular parasite called Toxoplasma gondii that found worldwide. Although efficient drugs are commonly used to treat toxoplasmosis, serious adverse events common. Therefore, new compounds with potent anti- T . activity needed provide better suited treatments. We have tested designed target specifically histone deacetylase enzymes. Among...
Virulence of apicomplexan parasites is based on their ability to divide rapidly produce significant biomass. The regulation cell cycle therefore key pathogenesis. Phosphorylation a crucial posttranslational modification that regulates many aspects the eukaryotic cycle. phosphatase PP1 known play major role in phosphorylation balance eukaryotes. We explored TgPP1 during tachyzoite form parasite Toxoplasma gondii. Using conditional mutant strain, we show including proper assembly daughter...
Pathogenesis of Toxoplasma gondii in the intermediate host is based on tachyzoite ability to divide rapidly produce significant amount daughter cells a reduce time frame. The regulation cell-cycle specific expression program therefore key their proliferation. Transcriptional has crucial role establishing this and transcription factors regulates many aspects cell cycle. We explored two ApiAP2 factors, TgAP2XII-9 TgAP2III-2, during cycle form. While TgAP2III-2 only minor impact proliferation,...
Background Histone deacetylase 8 from Schistosoma mansoni (SmHDAC8) is essential to parasite growth and development within the mammalian host under investigation as a target for of selective inhibitors novel schistosomicidal drugs. Although some protein substrates partners human HDAC8 have been characterized, notably indicating role in function cohesin complex, nothing known biological SmHDAC8. Methodology/Principal findings We therefore employed two strategies characterize SmHDAC8...
ABSTRACT Virulence of apicomplexan parasites is based on their ability to divide rapidly produce significant biomass. The regulation cell-cycle therefore key pathogenesis. Phosphorylation a crucial post-transcriptional modification that regulates many aspects the eucaryotic cell cycle. phosphatase PP1 known play major role in phosphorylation balance eukaryotes. We explored TgPP1 during cycle tachyzoite form parasite Toxoplasma gondii . Using conditional mutant strain, we show including...