A5007541648- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Sensors
- Nanopore and Nanochannel Transport Studies
Pohang University of Science and Technology
2022-2023
The frequent occurrence of viral variants is a critical problem in developing antiviral prophylaxis and therapy; along with stronger recognition host cell receptors, the evade immune system-based vaccines neutralizing agents more easily. In this work, we focus on enhanced receptor binding demonstrate generation receptor-mimicking synthetic reagents, capable strongly interacting viruses their variants. hotspot interaction receptor-derived short peptides maximized by aptamer-like scaffolds,...
Living cells efflux intracellular ions for maintaining cellular life, so intravital measurements of specific ion signals are significant importance studying functions and pharmacokinetics. In this work, de novo synthesis artificial K+ -selective membrane its integration with polyelectrolyte hydrogel-based open-junction ionic diode (OJID) is demonstrated, achieving a real-time ion-to-ion current amplification in complex bioenvironments. By mimicking biological channels nerve impulse...