A5045193651- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Curcumin's Biomedical Applications
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Nanopore and Nanochannel Transport Studies
- Protein Structure and Dynamics
- Electrochemical Analysis and Applications
- Retinoids in leukemia and cellular processes
- Ion Channels and Receptors
- Phytochemistry and biological activities of Ficus species
- Computational Drug Discovery Methods
- Rabbits: Nutrition, Reproduction, Health
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Lipid Membrane Structure and Behavior
- Seed and Plant Biochemistry
- Enzyme Catalysis and Immobilization
- Endoplasmic Reticulum Stress and Disease
- Multicomponent Synthesis of Heterocycles
Universidad Nacional Autónoma de México
2008-2021
Universidad Autónoma de la Ciudad de México
2018
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015
Medicina
2013
University of Virginia
2008
Amaranth is a rich nutrient pseudo cereal consumed since long time ago by ancient civilizations as the pre-Hispanic Mexicans who named it Huautli or Xtes.Today, keeps being included in human diet because of its nutraceutical relevance.Amaranth considered "super food" counts with high values such as: high-quality protein including several essential amino acids, unsaturated oils omega-3 and omega-6, dietary fiber, squalene, tocopherols, phenolic compounds, flavonoids, phytates, vitamins...
Mutations in the I-II loop of Cav3.2 channels were discovered patients with childhood absence epilepsy. All these mutations increased surface expression channel, whereas some mutations, and particular C456S, altered biophysical properties channels. Deletions around C456S found to produce that opened at even more negative potentials than control, suggesting presence a gating brake normally prevents channel opening. The goal present study was identify minimal sequence this provide insights...
The Ca(v)beta subunits of high voltage-activated Ca(2+) channels control the trafficking and biophysical properties alpha(1) subunit. Ca(v)beta-alpha(1) interaction site has been mapped by crystallographic studies. Nevertheless, how this leads to channel regulation not determined. One hypothesis is that betas regulate gating modulating movements IS6. A key requirement for direct-coupling model linker connecting IS6 alpha-interaction domain (AID) be a rigid structure.The present study tests...
In order to contribute the structural basis for rational design of calmodulin (CaM) inhibitors, we analyzed interaction CaM with 14 classic antagonists and two compounds that do not affect CaM, using docking molecular dynamics (MD) simulations, data were compared available experimental data. The Ca(2+)-CaM-Ligands complexes simulated 20 ns, starting in "open" "closed" conformations. analysis MD simulations provided insight into conformational changes undergone by during its these ligands....
Herein, we report the first characterization of Shab slow inactivation. Open channels inactivate within seconds, with two voltage-independent time constants. Additionally, presents significant closed-state We found that short depolarizing pulses, shorter than slowest inactivation constant, resulting curve has a marked U-shape, but as pulse duration increases, approaching steady-state conditions, U-shape vanishes, and curves converge to classical Boltzmann h∞ curve. Regarding mechanism...
The Arc two-component system modulates the expression of numerous genes in response to respiratory growth conditions. This comprises ArcA as regulator and ArcB sensor kinase. is a tripartite histidine kinase whose activity regulated by oxidation two cytosol-located redox-active cysteine residues that participate intermolecular disulfide bond formation. Here, we report protein segment covering 70–121, fulfills molecular characteristics leucine zipper containing coiled coil structure. Also,...
Celecoxib is a drug designed to selectively inhibit COX-2, an inflammation-inducible cyclooxygenase isoform, over the constitutively expressed COX-1 isoform. In addition this selective inhibition it now known that celecoxib exerts variety of effects on several types ion channels, thus producing secondary physiological effects. work we demonstrate at therapeutically relevant concentrations interacts with Shab K(+) channels specifically promoting fast inactivation gating (without blocking pore...
Curcumin, the most important secondary metabolite isolated from Curcuma longa, is known for its numerous purported therapeutic properties and as a natural dye. Herein, based on curcumin’s intrinsic fluorescence, search improved curcumin-based fluorophores was conducted. Within set of semi-synthetic curcumin derivatives i.e. mono (1), di (2), tri (3), tetra (4) benzylated dibenzyl-fluoroborate (5), fluorescence 2 5 in solution outstood with two-fold quantum yield compared to curcumin....
The expected (E)-but-3-en-2-ones compounds I and II (half curcuminoids) were obtained by the Claisen–Schmidt reaction between aldehydes 3,4-dimethoxybenzaldehyde or 4-nitrobenzaldehyde with acetone. Concomitantly, 3-methylcyclohex-2-enones III IV arose from an unexpected of but-3-en-2-ones in cascade a Michael-type addition second molecule acetone followed Robinson annulation under strong basic conditions. Both enones exhibit (E)-configuration, compound displays s-trans conformation, whereas...
Abstract The stereochemistry of two new 1,3‐diol curcuminoid derivatives, ((3R*,5R*)‐3,5‐dihydroxyheptane‐1,7‐diyl) bis (2‐methoxy‐4,1‐phenylene) diacetate namely rac‐ 6 , its acetylated derivative, (3R*,5R*)‐1,7‐bis(4‐acetoxy‐3‐methoxyphenyl) heptane‐3,5‐diyl ( 7 ) and the diastereomeric model compound 1,3‐bis(4‐methoxyphenyl)‐1,3‐propanediol rac ‐ 2 were investigated through their X‐ray crystal structures nuclear magnetic resonance spectra. Achiral compounds diacetylcurcumin 4...