A5081833847- Olfactory and Sensory Function Studies
- Medicinal Plants and Neuroprotection
- Biochemical Analysis and Sensing Techniques
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Fetal and Pediatric Neurological Disorders
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Neurological Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Retinal Imaging and Analysis
- Obstructive Sleep Apnea Research
- Neonatal and fetal brain pathology
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Prion Diseases and Protein Misfolding
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
University of Eastern Finland
2018-2025
Turku University Hospital
2018-2024
Neurology, Inc
2024
Kuopio University Hospital
2018-2022
Institute of Clinical Research
2022
University of Turku
2018
Center for Neurosciences
2018
Broad Institute
2018
Yamagata University
2018
Massachusetts General Hospital
2018
Background Frontotemporal lobar degeneration (FTLD) and primary psychiatric disorders (PPD) are characterised by overlapping clinical features but different aetiologies. Here, we assessed for the first time potential of blood glial fibrillar acidic protein (GFAP), marker astrogliosis, as a discriminative prognostic tool in FTLD PPD. Methods The levels GFAP serum (sGFAP) patients with (N=107) PPD (N=44) whole samples (bGFAP) from (N=10), (N=10) healthy controls (N=18) were measured. We...
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to remain poorly described. The aim of this study was evaluate mucosa differences between cognitively healthy individuals and disease patients. We report increased amyloid-beta secretion detail cell-type-specific gene expression patterns, unveiling 240...
An early symptom of Alzheimer's disease (AD) is an impaired sense smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), performed global RNA sequencing to determine gene expression changes. ONS expressed markers neuroglial differentiation, providing a unique cellular model explore changes AD-associated pathways. Our transcriptomics data revealed differentially genes...
Background Tear fluid (TF) is a protein-rich solution that reflects pathophysiological changes in Alzheimer's disease (AD). Objective In this study, we examined whether TF proteins were differently expressed persons with mild AD dementia compared to cognitively healthy controls (CO). Methods We analyzed data from 53 study participants including 34 CO (mean age, 71 years; Mini-Mental State Examination [MMSE] score, 28.9 ± 1.4), and 19 patients (Clinical Dementia Rating, 0.5–1; mean 72 MMSE...
Background: The suggested association between severe obstructive sleep apnea (OSA) and risk of Alzheimer’s disease (AD) needs further study. Only few recent reports exist on associations brain amyloid-β (Aβ) burden OSA in middle-aged patients. Objective: Examine the possible presence cortical Aβ accumulation patients with OSA. Methods: We performed detailed multimodal neuroimaging 19 cognitive intact (mean 44.2 years) (Apnea-Hypopnea Index >30 h–1). Known etiological factors for were used...
To evaluate the role of copy number loss in SFMBT1 a Caucasian population.Five hundred sixty-seven Finnish and 377 Norwegian patients with idiopathic normal pressure hydrocephalus (iNPH) were genotyped compared 508 elderly, neurologically healthy controls. The intron 2 was determined using quantitative PCR.The detected 10% (odds ratio [OR] = 1.9, p 0.0078) 21% (OR 4.7, < 0.0001) iNPH 5.4% No gains or carrier status did not provide any prognostic value for effect shunt surgery either...
Wide-ranging functional defects in eye movements have been reported Alzheimer's disease (AD) dementia. The detection of abnormal and reading problems may identify persons at risk AD when clear clinical symptoms are lacking.To examine whether computer-based eye-tracking (ET) analysis King-Devick (KD) test results differentiates cognitively healthy from with minor cognitive testing or diagnosed mild AD.We recruited 78 participants (57 non-demented, 21 AD) who underwent neurological...
Olfactory function, orchestrated by the cells of olfactory mucosa at rooftop nasal cavity, is disturbed early in pathogenesis Alzheimer's disease (AD). Biometals including zinc and calcium are known to be important for sense smell altered brains AD patients. Little about elemental homeostasis patient mucosa. Here we aimed assess whether disease-related alterations biometal observed brain also reflected We applied RNA sequencing discover gene expression changes related metals mucosal...
New biomarkers that improve diagnosis of Alzheimer's disease (AD) are warranted. Tear fluid (TF) containing variety proteins reflect pathophysiological changes systemic diseases makes TF potential biomarker candidates for AD.
Background: Functional defects in eye movements and reduced reading speed neurodegenerative diseases represent a potential new biomarker to support clinical diagnosis. We investigated whether computer-based eye-tracking (ET) analysis of the King-Devick (KD) test differentiates persons with idiopathic normal pressure hydrocephalus (iNPH) from cognitively unimpaired [control (CO)] Alzheimer’s disease (AD). Methods: recruited 68 participants (37 CO, 10 iNPH, 21 AD) who underwent neurological...
The gut microbiome is a complex system within the human gastrointestinal tract. bacteria play significant role in health, and some can promote inflammation pathologic processes through chemical interactions or metabolites. Gut dysbiosis has been linked to neurological other diseases. Here we aimed examine differences between patients with progressive disorder, idiopathic normal pressure hydrocephalus (iNPH), compared healthy controls (CO).
Abstract An early symptom of Alzheimer’s disease (AD) is an impaired sense smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), performed global RNA sequencing to determine gene expression changes. ONS expressed markers neuroglial differentiation, providing a unique cellular model explore AD-associated pathways. Our transcriptomics data revealed differentially genes...
ABSTRACT Olfactory dysfunction manifests early in several neurodegenerative disorders. Olfaction is orchestrated by olfactory mucosal cells located the upper nasal cavity. However, it unclear how this tissue reflects key features Alzheimer’s disease. Here we report that disease obtained from live individuals secrete toxic amyloid-beta. We detail cell-type-specific gene expression patterns, unveiling 147 differentially expressed disease-associated genes compared to cognitively healthy...