A5101648755- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Bladder and Urothelial Cancer Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer-related Molecular Pathways
- Chromosomal and Genetic Variations
- Phytoestrogen effects and research
- Hormonal and reproductive studies
- Pharmacological Effects of Natural Compounds
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Bacteriophages and microbial interactions
Xuzhou Central Hospital
2019-2023
Xuzhou Medical College
2022-2023
Nanjing University of Chinese Medicine
2022
Southeast University
2009
Background: Bladder urothelial carcinoma (BUC) ranks second in the incidence of urogenital system tumors, and treatment BUC needs to be improved. Puerarin, a traditional Chinese medicine (TCM), has been shown have various effects such as anti-cancer effects, promotion angiogenesis, anti-inflammation. This study investigates puerarin on its molecular mechanisms. Methods: Through GeneChip experiments, we obtained differentially expressed genes (DEGs) analyzed these DEGs using Ingenuity®...
Proper spindle formation and accurate chromosome segregation are essential for ensuring mitotic fidelity. Phosphatase tensin homolog (PTEN) is a multifunctional protein, which able to maintain the stability of genome chromosomes. The present study described an role PTEN in regulating prevent gross genomic instability via regulation arrest deficient 2 (MAD2). knockdown induced cell cycle abnormal segregation, manifested as anaphase bridges, lagging chromosomes premature chromatid separation....
To investigate the effect of corosolic acid treatment on erectile function in metabolic syndrome induced rat model. Fifty male 3-week-old SD rats were fed a high fat and sugar diet. Six months later, variables determined. Metabolic (MED) confirmed by an apomorphine test. Then MED treated with daily oral gavage for 4 weeks. evaluate function, intracavernosal pressure (ICP)/mean arterial blood (MAP) ratio was measured. Thiobarbituric reactive substances assay dihydroethidium staining used to...
Objective To construct the ancolytic adenovirus vector expressing SEA gene. Meth-ods The gene was amplified from standard staphylococcus aureus ATCC13565 by PCR method and then cloned into pCA13. Recombinant adenovirns plasmid pCA13-SEA identified co-transfected together with pBHGE3 293 packaging cells. Ad-SEA recombinant efficiently duplicated in cells purified CsCl density centrifugatian,and titer meas-ured. Results 771bp DNA sequencing showed that sequence same as of published sequence....
Objective To study the effect and mechanism of Momordica anti-HIV protein 30 ku (MAP30) on migration bladder cancer. Methods The IC50 human cancer 5637 T24 cells was calculated by methyl thiazolyl tetrazolium (MTT) method. The ability these two evaluated scratch test Transwell cell test. expression migrating proteins such as matrix metalloproteinases (MMPs) adhesion molecule N-cadherin were compared Western blot. Results Scratch test: there significant differences in rates at 8...