A5030324519- Alkaline Phosphatase Research Studies
- S100 Proteins and Annexins
- Vitamin D Research Studies
- Protease and Inhibitor Mechanisms
- Trace Elements in Health
- Parathyroid Disorders and Treatments
- Extracellular vesicles in disease
- Bone and Dental Protein Studies
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Selenium in Biological Systems
- Heterotopic Ossification and Related Conditions
Universidade de São Paulo
2022-2024
Sanford Burnham Prebys Medical Discovery Institute
2024
Discovery Institute
2024
Universidade de Ribeirão Preto
2022-2024
The biochemical machinery involved in matrix vesicles-mediated bone mineralization involves a specific set of lipids, enzymes, and proteins. Annexins, among their many functions, have been described as responsible for the formation stabilization vesicles' nucleational core. However, role each member annexin family, especially presence type-I collagen, remains to be clarified. To address this issue, vitro was carried out using AnxA6 (in solution or associated proteoliposomes) absence...
Matrix vesicles are a special class of extracellular thought to actively contribute both physiologic and pathologic mineralization. Proteomic studies have shown that matrix possess high amounts annexin A5, suggesting the protein might multiple roles at sites calcification. Currently, Annexin A5 is promote nucleation apatitic minerals close inner leaflet vesicles' membrane enriched in phosphatidylserine Ca2+. Herein, we aimed unravelling possible additional role by investigating ability...
Mineralizing cells release a special class of extracellular vesicles known as matrix (MV), crucial for bone mineralization. Following their release, MV anchor to the (ECM), where highly specialized enzymatic machinery facilitates formation seed mineral within MV's lumen, subsequently releasing it onto ECM. However, how propagate collagenous ECM remains unclear. In this study, we address these questions by exploring "protein corona" paradigm whereby nanoparticles entering biological milieu...