A5078483390- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- TGF-β signaling in diseases
- Digestive system and related health
- HER2/EGFR in Cancer Research
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Microscopic Colitis
Shahid Beheshti University of Medical Sciences
2011-2024
Shahid Beheshti University
2013
The influence of microsatellite instability (MSI) on the prognosis colorectal cancer (CRC) requires more investigation. We assessed role MSI status in survival individuals diagnosed with primary cancer. In this retrospective cross-sectional study was determined 158 formalin-fixed paraffin-embedded tumors and their matched normal tissues from patients who underwent curative surgery. Cox proportional hazard modeling performed to assess clinical prognostic significance. we found that MSI-H were...
Objective: Celiac disease (CD) and colorectal cancer (CRC) are distinct gastrointestinal conditions with a debated association. This study aimed to evaluate the mRNA expression of CD4 Foxp3 in tissue specimens CD CRC patients. The findings can provide valuable insights into complex connection between these different conditions. Methods: Tissue samples from 100 patients, 50 healthy controls (HCs) were collected. RNA extraction, cDNA synthesis, quantitative real-time PCR performed. Statistical...
One candidate gene for colorectal cancer (CRC) susceptibility is exonuclease 1 (EXO1). It a member of RAD2 nuclease family, which plays major role in mismatch repair, DNA replication, and recombination. Single-nucleotide polymorphisms are shown to be related with incidence. The aim the present study was examine association between L757P polymorphism at exon 13 EXO1 risk CRC Iranian patients.In this case-control study, 90 cases 98 healthy control samples were analyzed genetically....
Abstract The human epidermal growth factor 2 (HER2) gene undergoes various mutations that could alter its activity or respond to the antibody therapies. Cetuximab, a known anti‐EGFR monoclonal (mAB), is widely administered in metastatic colorectal cancer (mCRC) cases. Here we identified mCRC patients who did not cetuximab (500 mg/m , q2w) after fluoropyrimidine/oxaliplatin regimen failure. Tumor samples were examined with immunohistochemistry for protein distribution, polymerase chain...
Based on the analysis of patients with Peutz-Jeghers syndrome (PJS), Serine threonine kinase11 (STK11) is known as a tumor suppressor gene, which involved in cell polarization, regulation apoptosis, and DNA damage response. In this case report study, we examined STK11 gene sequencing 42-year-old woman mucocuta neous pigmentation positive family history. Endoscopy colonoscopy showed >1000 polyps throughout stomach/colon (PJ-type hamartomas). The larger polyp stomach was resected small bowel...
Abstract Background Approximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis cancer (HNPCC), is the most common form recognized CRC. Although Iran, a developing country, has high incidence CRC, spectrum variants yet to be thoroughly investigated. Aims This study aimed investigate pathogenic and non‐pathogenic in MLH1 MSH2 genes Iranian patients with suspected (sLS). Methods results In present study, 25 peripheral blood samples...
Colorectal cancer is the third-most-prevalent form of in world. Several studies report that prostaglandins are mediators carcinogenesis. Cyclooxygenase, also known as prostaglandin endoperoxidase H synthase, a pro-inflammatory enzyme intercedes formation eicosanoids from arachidonic acid. Polymorphisms COX-2 gene have been associated with increased risk different tumors, including colorectal. Genetic variations may affect activity or expression, thereby altering production and potentially...
Abstract Background and aim Colorectal cancer (CRC) originates from pre-existing polyps in the colon. The development of different subtypes CRC is influenced by various genetic epigenetic characteristics. CpG island methylator phenotype (CIMP) found about 15–20% sporadic CRCs associated with hypermethylation certain gene promoters. This study aims to find prognostic genes compare their expression methylation status as potential biomarkers patients serrated sessile adenomas/polyps (SSAP) CRC,...
Approximately 5% of colorectal cancers (CRCs) are hereditary. Lynch syndrome (LS), also known as hereditary nonpolyposis cancer (HNPCC), is the most common form recognized CRC. Although Iran, a developing country, has high incidence CRC, spectrum mutations yet to be thoroughly investigated. Therefore, this study aimed investigate pathogenic and non-pathogenic variants in MLH1 MSH2 genes Iranian patients with suspected (sLS). In present study, 25 peripheral blood samples were collected from...
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal cancer syndrome that characterized by the development of multiple adenomas in colon and rectum with high penetrance rates. This disease has specific features like occurrence pathogenic variations APC gene diverse FAP phenotypes due to region. In this study we aimed evaluate variants exons Iranian patients FAP. A total 35 individuals were referred gastroenterology ward Taleghani Hospital. As aim was germline...