A5030756625- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- COVID-19 and Mental Health
- Sinusitis and nasal conditions
- Exercise and Physiological Responses
- COVID-19 Impact on Reproduction
- Protease and Inhibitor Mechanisms
- Linguistics and Cultural Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 diagnosis using AI
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Cancer Immunotherapy and Biomarkers
- Occupational exposure and asthma
- Physical Activity and Health
- Nasal Surgery and Airway Studies
- Respiratory Support and Mechanisms
- Mast cells and histamine
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Physical Education and Training Studies
- Contact Dermatitis and Allergies
- Heart Rate Variability and Autonomic Control
St Petersburg University
2021-2025
City Hospital No. 40
2020-2025
S. M. Kirov Military Medical Academy
2017
In March 2020, the World Health Organization declared that an infectious respiratory disease caused by a new severe acute syndrome coronavirus 2 [SARS-CoV-2, causing 2019 (COVID-19)] became pandemic. our study, we have analyzed large publicly available dataset, Genome Aggregation Database (gnomAD), as well cohort of 37 Russian patients with COVID-19 to assess influence different classes genetic variants in angiotensin-converting enzyme-2 (ACE2) gene on susceptibility and severity outcome.We...
Since its first detection, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome 2) infection has spread rapidly around the world. Although primarily targets system, complications in other organ systems (cardiovascular, neurological, and renal) can also contribute to death from disease. Clinical experience thus far shown substantial heterogeneity trajectory of infection, spanning asymptomatic mild, moderate, severe forms with low survival rates. Accurate...
Training intensification is a generally accepted approach to improving athletic performance. A balance between training and recovery essential for athletes continuous achieve high levels of Without adequate muscle rest, an athlete may progress from optimal overtraining eventually syndrome (OTS). OTS negatively impacts athlete’s physical health Overtraining poorly understood area sports medicine. Monitoring athletes’ pre-competition preparation plays important role in developing programs....
COVID-19 is characterized by a wide range of clinical manifestations, from asymptomatic to extremely severe. At the onset pandemic, it became clear that old age and chronic illness were major risk factors. However, they do not fully explain variety symptoms complications SARS-COV-2 coronavirus infection. The research on genetic factors for still at its early stages. A number mutations polymorphisms have been identified affect structure stability proteins susceptibility infection, as well...
Extracorporeal blood purification is intended to eliminate dysregulation of the immune system. The concept extracorporeal therapy based on nonspecific clearance inflammatory mediators and triggers, which attenuates systemic expression mediators. main types are hemoadsorption plasma exchange. Hemoadsorption used primarily as an adjuvant treatment for septic shock other severe conditions, including forms COVID-19 with cytokine storm.
 Reliable data demonstrating benefit in critically ill...
Since SARS-CoV-2 first appeared in humans, the scientific community has tried to gather as much information possible order find effective strategies for containment and treatment this pandemic coronavirus. We reviewed current published literature on with an emphasis distribution of tissues body fluids, well data expression its input receptors cell surface. COVID-19 affects many organ systems ways. These varied manifestations are associated viral tropism immune responses infected person, but...
Early recognition of rupture-prone atherosclerotic lesions in patients with high-graded carotid stenosis is an important clinical problem for preventing ischemic stroke. Various pathophysiological mechanisms are responsible the progression and instability plaques, such as changes lipid composition, infiltration by immunoinflammatory cells degradation extracellular matrix vascular wall metalloproteinases, enhanced inflammatory response plaque neovascularization. These features main cause...
The COVID-19 pandemic is caused by the SARS-CoV-2 coronavirus. From viewpoint of factors critical to contain virus, neutralizing antibodies garner most attention, however, it essential acknowledge that level virus-specific T cell and B response forms a basis for an effective antibody response. responses develop early correlate with protection, but they are relatively attenuated in severe disease, part due lymphopenia. Understanding role different subpopulations protection or pathogenesis...
Most commonly, COVID-19 presents as a respiratory disease, but growing body of clinical evidence shows that neurological symptoms and complications contribute significantly to the spectrum especially in patients with severe disease. The public health impact long-term (or even life-long) consequences disease may be much greater than acute manifestations SARS-CoV-2 infection. As pandemic has evolved, number part increased. diverse range from mild (myalgia, headache, fatigue, dizziness,...
Chronic rhinosinusitis with nasal polyps is a heterogeneous disease characterized by local inflammation of the upper airways. Inflammation in chronic divided into 3 main endotypes different pathophysiology and various forms inflammation: T1, T2, T3. Epithelial barrier dysfunction common feature induced endotype-specific cytokines directly indirectly. The sinonasal epithelium not only functions as passive but also an active immunological organ innate adaptive components. Violation delicate...
COVID-19 is primarily a respiratory disease, but it brings significant risk of acute kidney injury or exacerbation pre-existing especially in patients with comorbidities such as hypertension, coronary artery chronic liver and malignancies. We reviewed studies that assessed the association between disease SARS-CoV-2 coronavirus infection outcomes, including hospitalization, severe COVID-19, need for intensive care, progression, patient death. The results are varied often contradictory,...
. Literature data on the risk of SARS-CoV-2 coronavirus infection in people with inflammatory rheumatic diseases (RD) are contradictory. According to most studies, and development severe forms COVID-19 is higher patients RD compared general population, but largely depends type activity RD. Patients often required mechanical ventilation died more often. This due immune dysfunction caused by both disease itself antirheumatic therapy using immunomodulatory drugs. The state immunosuppression,...
Сепсис — это тяжелая системная инфекция с дисфункцией органов, требующая неотложных действий. При недостаточно оперативном и эффективном вмешательстве летальность превышает 30 %. Неоднородность сепсиса является причиной неудач клинических испытаний иммуномодулирующей терапии пациентов сепсисом. Из-за недостаточного понимания патогенеза этой неоднородности методы лечения, казавшиеся многообещающими в доклинических условиях, не имели успеха испытаниях. Отчасти отсутствие эффективности связано...
Background: According to WHO, as of March 31, 2021, 127 877 462 confirmed cases the new COVID-19 coronavirus infection were registered in world, including 2 796 561 deaths (WHO Coronavirus Disease). is characterized by a wide range clinical manifestations, from asymptomatic rapid progression severe and extremely severe. Predictive biomarkers for early detection high-risk individuals have become matter great medical urgency. Aims: Search predictors cytokine storm patients with creation risk...
Cerebral palsy is a neurological disorder that attributed to non-progressive injury or malformation occurred in the developing fetal infant brain. The motor disorders cerebral are often accompanied by disturbances of sensation, perception, cognition, communication, behaviour, and epilepsy. complex likely be multifactorial origin. Epidemiological studies have shown origins most CP prior labor. A number clinical risk factors for been described literature including preterm birth, low birth...
Objective: to study the association of C-reactive protein (CRP) with cytokines in polytrauma. Subjects and methods. Eighty-four victims severe concomitant injury were examined. Twenty-five (29.7%) patients developed sepsis, death being observed 83.3%. CRP was daily determined sera victims, by using latex test kits (HUMATEX, Germany). On days 1, 3, 7, 10, 15 after injury, serum lymphocytic culture IL-2, IL-4, TNF-a, IFN-y, HLA-DR studied on an automatic Elx 800 Universal Microplate Reader...
Chronic rhinosinusitis (CRS) is the most common immunological ENT disease, which has several phenotypes. The heterogeneity of CRS due to peculiarities their pathogenetic mechanisms - system cytokines plays crucial significance. They are biologically active substances and present regulatory peptides that demonstrate an immunomodulatory effects not only in local level but as well.To determine specific features cytokine profile blood serum among patients with without polyps (CRSwP).Serum...
The genetic variability of population may explain different individual immune responses to the SARS-CoV-2 virus. use genome- and peptidome-based technologies makes it possible develop vaccines by optimizing target antigens. computer modeling methodology provides scientific community with a more complete list immunogenic peptides, including number new cross-reactive candidates. Studies conducted independently each other approaches provide high degree confidence in reproducibility results....
Cardiac rehabilitation based on exercise therapy is a valuable treatment for patients with broad spectrum of cardiovascular diseases. Current guidelines support its use in stable chronic heart failure and coronary artery disease, after myocardial infarction, acute syndrome, bypass grafting, stent placement, valve surgery. Its these conditions supported by robust body research demonstrating improved clinical outcomes. The significant improvement obtained through the regular training diseases...