A5042739509- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Lipid Membrane Structure and Behavior
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Virology and Viral Diseases
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Cardiac Ischemia and Reperfusion
- Parkinson's Disease Mechanisms and Treatments
- Bacterial biofilms and quorum sensing
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
Max Planck Institute of Immunobiology and Epigenetics
2016-2021
University of Freiburg
2016-2021
Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism self-limit swarming avoid uncontrolled aggregation during inflammation. G protein-coupled receptor (GPCR) desensitization acts as a negative feedback control stop migration when they sense high concentrations self-secreted attractants...
Background: Platelets store large amounts of serotonin that they release during thrombus formation or acute inflammation. This facilitates hemostasis and modulates the inflammatory response. Methods: Infarct size, heart function, cell composition were analyzed in mouse models myocardial reperfusion injury with genetic pharmacological depletion platelet serotonin. These studies complemented by vitro stimulation assays platelets leukocytes mice men, measuring plasma levels leukocyte activation...
Although intrastriatal transplantation of fetal cells for the treatment Parkinson's disease had shown encouraging results in initial open-label clinical trials, subsequent double-blind studies reported more debatable outcomes. These highlighted need greater preclinical analysis parameters that may influence success cell therapy. While much this has focused on and location transplants, few have attempted to replicate potentially critical patient centered factors. Of particular relevance is...