A5041058079- Pregnancy-related medical research
- Neurobiology and Insect Physiology Research
- Retinal Development and Disorders
- Retinoids in leukemia and cellular processes
- Animal Behavior and Reproduction
- Plant Molecular Biology Research
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Silk-based biomaterials and applications
- Antioxidant Activity and Oxidative Stress
- Retinal Diseases and Treatments
Universidad Nacional del Sur
2015-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
Centro Científico Tecnológico - Bahía Blanca
2016-2021
Universidade Nova de Lisboa
2020-2021
How different organs in the body sense growth perturbations distant tissues to coordinate their size during development is poorly understood. Here we mutate an invertebrate orphan relaxin receptor gene, Drosophila Leucine-rich repeat-containing G protein-coupled 3 (Lgr3), and find asymmetries similar those found insulin-like peptide 8 (dilp8) mutants, which fail with developmental timing. Indeed, mutation or RNA intereference (RNAi) against Lgr3 suppresses delay pupariation induced by...
At the end of their growth phase, Drosophila larvae remodel bodies, glue themselves to a substrate, and harden cuticle in preparation for metamorphosis. This process—termed pupariation—is triggered by surge hormone ecdysone. Substrate attachment is achieved pupariation subprogram called expulsion spreading behavior (GSB). An epidermis-to-CNS Dilp8-Lgr3 relaxin signaling event that occurs downstream ecdysone critical unlocking progression motor program toward GSB, but factors circuits acting...
Ovulation allows mature oocytes to exit the ovary for potential fertilization. In Drosophila , ovulation can be induced by mating or occur spontaneously in lower amounts virgin females. Virgin rates show high populational variation, with short oocyte retention times being ancestral, and long selected colder climates. The molecular mechanisms controlling are poorly understood. Here, we that reduced activity of insulin-like peptide 8 (Dilp8), a relaxin-like secreted from terminal follicle...
Abstract Innate behaviors consist of a succession genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into mechanisms by studying pupariation, multi-step innate behavior Drosophila larvae critical for survival during metamorphosis. We find the steroid-hormone ecdysone triggers parallel pupariation neuromotor subprograms, which...
Abstract How different organs in the body sense growth perturbations distant tissues to coordinate their size during development is poorly understood. Here, we mutated an invertebrate orphan relaxin receptor, Drosophila Lgr3 , and found asymmetries similar those insulin/relaxin-like peptide 8 ( dilp8 ) mutants, which fail with developmental timing. Indeed, mutation or RNAi against suppresses delay pupariation induced by imaginal disc perturbation ectopic Dilp8 expression. By...
Müller glial cells (MGC) are stem in the retina. Although their regenerative capacity is very low mammals, use of MGC as to regenerate photoreceptors (PHRs) during retina degenerations, such retinitis pigmentosa, being intensely studied. Changes affecting PHRs diseased retinas have been thoroughly investigated; however, whether also affected still unclear. We here investigated retinal degeneration 1 (rd1) mouse, an animal model impaired cell properties or structure. rd1 showed altered...
ABSTRACT At the end of their growth phase, Drosophila larvae remodel bodies, firmly glue themselves to a substrate, and harden cuticle in preparation for metamorphosis. This process is termed pupariation it triggered by surge steroid hormone ecdysone. Substrate attachment achieved recently-described subprogram called expulsion spreading behavior (GSB). An epidermis-to-CNS Dilp8-Lgr3 relaxin signaling event that occurs downstream ecdysone after initiation critical unlocking progression motor...
Abstract Innate behaviors consist of a succession genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into mechanisms by studying pupariation, multi-step innate behavior fly larvae critical for survival during metamorphosis. We find the steroid-hormone ecdysone triggers parallel pupariation neuromotor subprograms, which include...