A5026407045- Rheumatoid Arthritis Research and Therapies
- Structural Load-Bearing Analysis
- Quantum, superfluid, helium dynamics
- Atomic and Subatomic Physics Research
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- interferon and immune responses
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Gastroesophageal reflux and treatments
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Structural Behavior of Reinforced Concrete
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Dermatology and Skin Diseases
- Structural Engineering and Vibration Analysis
- Sports Performance and Training
- Bone Metabolism and Diseases
TEPCO (Japan)
2025
Kobe University
2015-2024
University of Hyogo
2019-2023
Akita University
2023
Nippon Shinyaku (Japan)
2023
Matsubara Mayflower Hospital
2021-2022
Kobe University of Future Health Sciences
2020
John Wiley & Sons (United States)
2020
Municipal Hirakata City Hospital
2019
Kohnan Hospital
2017
Migration of smooth muscle cells (SMCs) the media through internal elastic lamina to intima in response various chemoattractants is considered be an important event development atherosclerosis. We evaluated influence elastin peptides prepared from normal aorta on migration cultured rat aortic SMCs vitro. Studies with filters coated a modified Boyden's chamber showed that migratory platelet-derived factors was impeded by filter-bound peptides. The inhibitory effect appeared relatively...
ABSTRACT Borna disease virus (BDV) p24 RNA was detected in the peripheral blood mononuclear cells (PBMCs) of psychiatric patients and donors by nested reverse transcriptase PCR (RT-PCR). The prevalences BDV with mood disorders (4%) schizophrenia were not significantly different from that (2%). This finding inconsistent previous reports showed either a high prevalence or absence disorders. differences these studies may be due to criteria for positivity, number PBMCs used extraction, amount...
Persistent foramen tympanicum (Huschke) is an anatomical variation located in the anteroinferior portion of external auditory canal. We present a case symptomatic temporomandibular joint (TMJ) herniation into canal though enlarged osseous defect. The herniated retrodiscal TMJ tissue moved backward when patient’s mouth was closed, and forward, opened. Magnetic resonance imaging findings were useful for differentiating from salivary fistula caused by ectopic gland.
Abstract Eicosapentanoic acid (EPA) is an antioxidant and omega‐3 polyunsaturated fatty that reduces inflammatory cytokine production. Gelatin hydrogel can be used as a carrier of physiologically active substance release it gradually for average ~3 weeks. Therefore, this study aimed to clarify the effect EPA‐incorporating gelatin hydrogels on osteoarthritis (OA) progression in vivo. Ten‐week‐old male C57BL/6J mice were randomly divided into six groups ( n = 6): Sham, destabilization medial...
Pulsed NMR experiments of Carr-Purcell-Meiboom-Gill type have been performed on water flowing through a circular pipe. Spin echo signals were detected rf phase-sensitively in highly stabilized electromagnet with linear field gradient. The flow patterns studied Poiseuille flows and turbulent flows. From measurements the first spin signal amplitudes, information velocity profile for various obtained, while from those second fluctuations obtained. In states, both component parallel to axis pipe...
Mitochondrial frataxin is involved in various functions such as iron homeostasis, iron-sulfur cluster biogenesis, the protection from oxidative stress and apoptosis acts a tumor suppressor protein. We now show that expression of stimulated p53-dependent manner prove direct p53 target gene by showing p53-responsive element promoter mouse bound p53. The bacterial human maturation ferrochelatase, which catalyzes insertion into protoporphyrin at last step heme biosynthesis. Overexpression cancer...
Patients with rheumatoid arthritis (RA) are frequently complicated gastric mucosal injury; however, there few reports investigating gastroesophageal reflux disease (GERD) among patients RA. We investigated the frequency of GERD and correlation between clinical characteristics RA including patient's global assessment (PGA).Patients were for using self-administered scale symptoms (FSSG). The was analyzed statistically.Two hundred eleven in Japan investigated. prevalence (24.6%) significantly...
3-Deazaadenosine analogs can function as inhibitors and also alternative substrates of S-adenosylhomocysteine (AdoHcy) hydrolase. In cells treated with the analogs, AdoHcy invariably accumulates, leading to inhibition cellular methylation. F9 teratocarcinoma cells, stably transfected two collagen (IV) promoter-enhancer-CAT constructs 10 microM 3-deazaadenosine, 3-deaza-(+-)-aristeromycin or 3-deazaneplanocin, showed a strong induction CAT activities without affecting differentiation....
Textures, textural transformation, and formation annihilation of a single vortex were investigated in narrow cylinders with 100 microm radius A-phase under rotation up to 6.28 rad/sec. Three textures found, depending on the cooling conditions sample through superfluid transition temperature T(c). We found gyromagnetic effect textures; that is, two (A or B) could be selected either by applying magnetic field parallel anti-parallel axis. The critical angular speed Omega(f) Omega(a) for each...
To investigate the prevalence of abnormalities paranasal sinus detected by magnetic resonance imaging (MRI) in asymptomatic subjects.Prospective study.Outpatient clinic.A total 325 patients who underwent MRI for suspected intracranial disease. Of those, 257 lacked nasal or symptoms.Sinus were seen on 153 (47.1%) patients, including 107 (41.6%) patients. Subjects older than 50 years had a significantly higher frequency (49.8%) vs those younger (39.5%) (P < .05). The maxillary abnormality was...
Cry j 1 and 2 are known to be the major allergens of Japanese cedar pollen. A comparative study was carried out on immune responses stimulation with in 24 symptomatic patients six nonallergic subjects. In T‐cell proliferation assays, mean indexes (SI) were 10.6 for 11.7 stimulation, respectively, allergic patients. Two subjects showed strong both allergens, while remainder did not. All (17/17) high titers anti‐Cry IgE antibody at a value 165 U/ml, whereas only 64% responded low 26 U/ml....
Decoy receptor 3 (DcR3), a member of the tumor necrosis factor (TNF) (TNFR) superfamily, lacks transmembrane domain conventional TNFRs in order to be secreted protein. DcR3 competitively binds and inhibits members TNF family, including Fas ligand (FasL), LIGHT TNF-like 1A (TL1A). We previously reported that TNFα-induced overexpression rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) protects cells from Fas-induced apoptosis. Previous studies have suggested acting as directly...
The immunodominant regions of the Japanese cedar pollen allergen Cry j 2 for T‐cell immunity were determined with whole peripheral blood lymphocytes (PBL) derived from seven allergic patients and three nonallergic subjects. 2‐stimulated proliferation was inhibited by anti‐HLA‐DR. but not anti‐HLA‐DQ antibody, indicating that responding T cells recognized peptides associated HLA‐DR molecules. It found 2, i.e., corresponding to amino acid numbers 1–26, 70–84, 151–167. 187–203, 252–279,...
Study Design: Retrospective comparative study. Objective: To elucidate the indications and limitations of conservative treatment for pyogenic spondylitis (PS). Summary Background Data: The optimal strategy treating PS, or surgical, remains controversial. Methods: Sixty-eight consecutive patients (44 males, 24 females; 62.6±13.8 y) suffering from PS were enrolled. Forty-three successfully treated with therapy including immobilization administration antibiotics [conservative success (CTS)...
The effect of proton pump inhibitors (PPIs) on the health-related quality life (HRQoL) patients with laryngopharyngeal reflux disease (LPRD) is not well known. Our aim was to assess HRQoL before and after administration a PPI in LPRD.A total 27 LPRD (14 women, 13 men; mean age 54 years) were enrolled. We determined using three different inquiry systems: 1) Frequency Scale for Symptoms GERD (FSSG); 2) 36 item short form Medical Outcome Study Questionnaire (SF-36); 3) Gastrointestinal Symptom...
Sulfamethoxazole-trimethoprim, an antimicrobial agent, was used to treat three cases of cytotoxic agent-resistant Wegener's granulomatosis; one case refractory a regimen consisting azathioprine and prednisolone, in another two the therapy insufficient control disease. By introduction sulfamethoxazole-trimethoprim, which has advantage fewer side effects compared with conventional agents, into regimen, disease condition markedly improved all within four months. Sulfamethoxazole-trimethoprim is...
Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which rate‑limiting enzyme serotonin synthesis. The aim present study was to determine specificity effects DcR3 on TPH1 RA‑FLS, therefore whether had potential modulate pathogenesis RA. also aimed compare inflammatory cytokines RA‑FLS osteoarthritis (OA)‑FLS. Primary cultured RA‑ or OA‑FLS were incubated with 1.0 µg/ml DcR3‑Fc...
Retrospective study.To examine the prevalence of lower urinary tract symptoms (LUTS) and neurogenic bladder (NB), surgical outcomes in pure cervical spondylotic myelopathy.The inclusion various types diseases, NB, no obvious definition NB provided wide range frequency among previous reports.Of 220 operated patients with myelopathy, 54 were selected by excluding other and/or concomitant diseases contributing to LUTS. All LUTS referred urologists recommended undergo urodynamic study (UDS). The...
Abstract This study observed anterior coverage extent after lateral rotation of the acetabulum, without or posterior rotation, during curved periacetabular osteotomy by three‐dimensional simulation, and determined if preoperative pelvic morphology affects postoperative range motion. Thirty patients scheduled for consecutive primary developmental hip dysplasia at our hospital between 2016 2017 were included. Virtual acetabular osteotomies performed to achieve a center‐edge angle 30°. We...
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of tissues leads to the formation pannus invades joint cartilage and bone, resulting destruction. Fas ligand (FasL), which a member tumor necrosis factor superfamily, contributes pathogenesis diseases, including RA. The current study attempted identify genes whose expressions rheumatoid fibroblast‑like synoviocytes (RA‑FLS) were regulated by FasL, using cDNA microarray. A...
Genetic polymorphisms might serve as useful prognostic markers for the timely diagnosis of RA. The purpose this study was to identify genomic factors predictive occurrence interstitial lung disease (ILD) in RA by performing a genome-wide association genetic variants, including single nucleotide (SNPs).The population included 306 patients. All patients were treated with conventional DMARDs, 6-16 mg MTX per week. Clinical data and venous blood samples collected from all before administration...
ABSTRACT Improving patient health‐related quality of life (HRQOL) and prevention bone fracture are important components the treatment osteoporosis. Our aim in this study was to evaluate effect denosumab improving HRQOL among patients with analysis based on 332 osteoporosis, followed for 24 months. All received (60 mg) subcutaneously every 6 Bone mineral density (BMD) assessed at distal radius, serum concentration calcium, phosphate, P1NP, TRACP5b also measured. assessment included pain...