A5085881799- Kruppel-like factors research
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Genetic Syndromes and Imprinting
- Metastasis and carcinoma case studies
University of Southampton
2013-2019
Southampton General Hospital
2018
Interactions between cancer cells and cancer-associated fibroblasts (CAFs) play an important role in tumour development progression. In this study we investigated the functional of CAFs oesophageal adenocarcinoma (EAC). We used immunochemistry to analyse a cohort 183 EAC patients for CAF markers related disease mortality. characterized normal (NOFs) using western blotting, immunofluorescence gel contraction. Transwell assays, 3D organotypic culture xenograft models were examine effects on...
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in dogma that translation rates are slowed during mitosis, with cap-independent favored to give expression key regulatory proteins. However, such culture studies involve synchronization using harsh methods, which may themselves stress cells and affect protein synthesis rates. One commonly used chemical is microtubule de-polymerization agent, nocodazole, arrests mitosis has demonstrate...
Abstract Rituximab is an anti-CD20 mAb used in the treatment of B cell malignancies. Loss surface CD20 Ag from target cells thought to be one mechanism governing resistance rituximab, but how this occurs not completely understood. Two explanations for have been proposed: antigenic modulation whereby mAb:CD20 complexes are internalized a intrinsic process and shaving, which undergo trogocytic removal by effector cells, such as macrophages. However, there conflicting evidence predominates...