A5008687278- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Veterinary Oncology Research
- Pluripotent Stem Cells Research
Hokkaido University
2018-2025
Radio-resistance of cancer stem-like cells (CSCs) is associated with the failure radiation therapy. ZsGreen1-positive (ZsG⁺) cells, which exhibit low proteasome activity, have been used to enable detection and isolation CSCs. However, mechanisms radio-resistance in canine tumor activity remain unclear. This study aimed elucidate ZsG+ by identifying a potential target isolated using flow cytometric cell sorting, were compared ZsG- cells. Sulfasalazine was suppress glutathione (GSH) synthesis...
Cancer stem-like cells (CSCs) are self-renewing comprising a small subpopulation in tumours, and generate differentiated progeny through asymmetric division. It has been shown that CSCs resistant to ionizing radiation, this feature could be one of the mechanisms tumour recurrence after radiation therapy. Much attention focused on target CSCs; however, difficult isolating lack knowledge their radiosensitivity have limited kind research veterinary medicine. In present study, sphere-forming...
Cancer stem-like cells (CSCs) cause treatment failure in various tumours; however, establishing CSC-targeted therapies has been hampered by difficulties the identification and isolation of this small sub-population cells. Recent studies have revealed that tumour with low proteasome activity display a CSC phenotype can be utilized to image CSCs canines. This study visualizes reveals CSC-like properties HMPOS (osteosarcoma) MegTCC (transitional cell carcinoma), which are canine lines. The...