A5027593669- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Luminescence and Fluorescent Materials
- Machine Learning in Materials Science
- Catalytic Processes in Materials Science
- Catalytic Alkyne Reactions
- Synthesis and biological activity
- Organic Light-Emitting Diodes Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Asymmetric Hydrogenation and Catalysis
- Organic Electronics and Photovoltaics
- Bioactive Compounds and Antitumor Agents
Samsung (South Korea)
2022-2023
Institute for Basic Science
2014-2017
Korea Advanced Institute of Science and Technology
2012-2017
Catalytic Materials (United States)
2015
Pd-catalyzed oxidative Heck reactions of coumarins were developed via simultaneous C-H functionalization at the C3 position under aerobic conditions.
Light-promoted phosphonation of quinolinones and coumarins was developed without the need for an external photocatalyst. Investigations support a mechanism whereby both starting materials products act as photosensitizers upon excitation using compact fluorescent light sources to photochemically promote dissociation N–O bond in pyridinium salt by single electron transfer pathway. A wide range quinolinone coumarin substrates can be utilized process under mild reaction conditions.
The automation of organic compound synthesis is pivotal for expediting the development such compounds. In addition, enhancing efficiency can be achieved by incorporating autonomous functions alongside automation. To achieve this, we developed an robot that harnesses power artificial intelligence (AI) and robotic technology to establish optimal synthetic recipes. Given a target molecule, our AI initially plans pathways defines reaction conditions. It then iteratively refines these using...
An efficient method for the C4-regiocontrolled C–H functionalization of coumarins to enable facile oxidative cross-couplings with simple arene components is disclosed.
One-pot reactions leading to highly functionalized coumarins have been developed via a Pd(II)-catalyzed dehydrogenation–oxidative Heck–cyclization process.
Pd(<sc>ii</sc>)-catalyzed direct arylation of chromones and enaminones gives divergent site-selectivities. Computational experimental studies reveal a switch in mechanism, from C3-selective CMD mechanism to C2-selective carbopalladation pathway. This model accounts for the opposite selectivities enaminone chromone, also correctly predicts C–H functionalization heteroaromatic substrates as function coupling partner.
Abstract Efficient rhodium‐catalyzed direct C–H phosphorylation of (hetero)arenes was developed. Various directing groups and a wide range substrates, including heterocycles, can be utilized in this process, allowing for the rapid installation phosphonate group into medicinally biologically important privileged scaffolds. The efficient straightforward method could serve as new tool to streamline late‐stage functionalization preparing aryl phosphonates, which are structural motif synthetic...
A Pd-catalyzed direct cross-coupling of 3-bromocoumarins with heteroarenes provided an efficient route to synthesizing 3-heteroarylcoumarins. The reaction scope for the transformation was fairly broad, affording modest good yields various 3-heteroarylcoumarin scaffolds, which are privileged structures and prevalent motifs in many biologically active compounds fluorophores.
Flavone from benzene: An efficient regiocontrolled CH functionalization of chromones at the C2 position is described. This method enables facile oxidative cross-coupling reactions with non-activated arenes by a palladium-catalyzed twofold functionalization. The substrate scope broad and permits construction various flavone derivatives, which are privileged structures as well prevalent motifs in many biologically active compounds. Detailed facts importance to specialist readers published...
An efficient method for the direct C–H olefination of sulfocoumarins with a wide range alkenes is developed. Moreover, O<sub>2</sub> was successfully utilized as sole oxidant oxidative Heck reaction. This approach enables rapid generation various 3-alkenylated sulfocoumarins.
Abstract Irradiation of 9‐ester‐substituted anthracenes with visible light results in the formation endoperoxides absence a photocatalyst, which further undergo base‐assisted fragmentation to afford anthraquinones. The excited state species anthracene generated by energy transfer, interacts 3 O 2 1 transfer and undergoes cycloaddition . By employing palladium(II)‐catalyzed light‐mediated transformations, we have developed an efficient synthetic protocol for accessing diverse anthraquinones...
Abstract Depending on the amount of AgSbF 6 used, this hydroarylation alkynes yields either E‐ or Z‐triarylalkenes.
Abstract An efficient method for the regioselective C—H olefination of sulfocoumarins with a wide range alkenes is developed using O 2 as sole oxidant.
Abstract A variety of 3‐vinyl and 3‐styryl coumarin derivatives (III) is prepared by oxidative Heck reaction coumarins (I) in pivalic acid as solvent.
Abstract A simple procedure is elaborated for the preparation of coumarins (III) by an oxidation cyclohexanones (I) followed oxidative Heck coupling‐cyclization process resulting phenols with butyl acrylate.
Abstract A novel method for the C4‐regiocontrolled oxidative cross‐coupling of coumarins (I) and unactivated arenes (II) via a Pd‐catalyzed twofold C—H functionalization is described.
Abstract The spectroscopic properties of all synthesized compounds are investigated in CH 2 Cl .