A5069447565- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Invertebrate Immune Response Mechanisms
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Developmental Biology and Gene Regulation
Johns Hopkins University
2019-2024
The expression of core histone genes is coupled to DNA replication the genome support chromatin packaging. In Drosophila, are repeated in one locus as a 100-copy array and forms Histone Locus Body; these multiple copies varying rates cell proliferation different developmental stages various tissues animal. We show here that Drosophila Body contains mix active silenced units. male germline reporter repeat units strongly silenced, we used this setting test dependence on factors histones. find...
Abstract Many cell types come from tissue-specific adult stem cells that maintain the balance between proliferation and differentiation. Here, we study how H3K4me3 methyltransferase, Set1, regulates early-stage male germ differentiation in Drosophila . Early-stage germline-specific knockdown of set1 results a temporally progressed defects, arising as loss developing to overpopulated cells. These germline defects also impact niche architecture cyst lineage non-cell-autonomous manner....
Many tissue-specific adult stem cell lineages maintain a balance between proliferation and differentiation. Here, we study how the H3K4me3 methyltransferase Set1 regulates early-stage male germ cells in Drosophila. Early-stage germline-specific knockdown of results temporally progressive defects, arising as loss developing into overpopulated cells. These germline defects also impact niche architecture cyst lineage non-cell-autonomously. Additionally, wild-type Set1, but not catalytically...