A5059989341- interferon and immune responses
- RNA modifications and cancer
- Tryptophan and brain disorders
- RNA and protein synthesis mechanisms
- Herbal Medicine Research Studies
- Gut microbiota and health
- Urinary Tract Infections Management
- Pediatric health and respiratory diseases
- Graphene and Nanomaterials Applications
- Influenza Virus Research Studies
- Stress Responses and Cortisol
- Nanoparticles: synthesis and applications
- Cancer Cells and Metastasis
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Escherichia coli research studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Saffron Plant Research Studies
- Berberine and alkaloids research
- Flavonoids in Medical Research
- Silymarin and Mushroom Poisoning
- Healthcare and Venom Research
- Inflammasome and immune disorders
- Polysaccharides and Plant Cell Walls
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Jining Medical University
2020-2021
China Academy of Chinese Medical Sciences
2021
Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created NSCLC and studied potential molecular by which C. relieved using combination transcriptomics, proteomics, experimental validation. Results markedly suppressed fluorescence values mice with NSCLC, improved pathologic morphology tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6,...
Abstract Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks definitive treatment. Cordyceps sinensis (CS), renowned for its pharmacological properties in traditional Chinese medicine extensive use treatment, holds promise as therapeutic agent IPF. However, the specific role of CS treating IPF remains unclear. In this study, we aimed to assess efficacy unravel potential mechanisms. Our results demonstrate...
Puerarin has been reported as a potential agent for neuro-inflammatory disorders. However, there have no reports of using puerarin the treatment depression based on Toll-like receptor 4 (TLR4)-mediated inflammatory injury. In this study, we evaluated protective effects depression-like rats induced by high-fat diet (HFD) combined with chronic unpredictable mild stress (CUMS). The mechanism was screened lipidomics and molecular docking confirmed in vivo tests. significantly improved 1% sucrose...
ContextKaihoujian Throat Spray children's type (KHJSC) is a Chinese medicine prescription for treating pediatric acute pharyngitis and tonsillitis (APT). However, its relevant mechanisms remain unclear.ObjectiveTo investigate the pharmacological effects of KHJSC on APT in vitro vivo, explore possible mechanism target proteins.Materials methodsThe antiviral antibacterial were evaluated by IC50 MICs. Thirty-six Japanese white rabbits averagely divided into control group, model amoxicillin...
Geniposide, an iridoid glycoside purified from the fruit of
The seeds of Vaccaria segetalis (Neck.) are from a traditional medicinal plant Garcke, also called Wang-Bu-Liu-Xing in China. According to the Chinese Pharmacopoeia, V. can be used for treating urinary system diseases. This study was designed investigate underlying mechanism VSP (polysaccharides segetalis) against tract infections caused by uropathogenic Escherichia coli (UPEC). Here, both vitro and vivo infection models were established with UPEC strain CFT073. Bacterial adhesion invasion...
The roots of Scrophularia ningpoensis Hemsl. are a famous traditional Chinese medicinal herb and also used as health food. However, information about polysaccharides from S. (SNPS) is very limited. We applied the ultrasonic‐assisted extraction (UAE) process to extract SNPS. UAE conditions were optimized using single‐factor experiments response surface analysis. Under ultrasonic power 550 W, time 26 min, temperature at 50°C, highest yield 13.47% ± 1.63% was obtained, which in accordance with...
We are committed to finding host targets for influenza A therapeutics. The nucleoprotein (NP) plays an important role in virus replication and is indispensable part of viral transcription replication. Exploring endogenous substances that can modulate NP critical targets. MicroRNAs (miRNAs, miR) a novel class powerful, gene expression regulators. Herein, we used miRanda analyse the base complementarity between 14 miRNAs reported previously by us. MiRanda predicted miR-431-5p, miR-744-3p...
Shenyu Ningshen (SYNS) tablet is the first pure Chinese medicinal small compound preparation approved for clinical trials treatment of depression in China. Clinical experiments confirmed that formulation had a significant Improvement effect against due to deficiency both qi and yin. It has been shown exhibit noticeable anti-inflammatory an animal model depression. Our previous study showed SYNS could effectively inhibit inflammatory response model.
Abstract BackgroundGeniposide, an iridoid glycoside purified from the fruit of Gardenia jasminoides Ellis, has been reported to possess pleiotropic activity against different diseases. In particular, geniposide possesses a variety biological activities and exerts good therapeutic effects in treatment several strains influenza virus. However, molecular mechanism for effect not well defined.MethodsThis study aimed investigate on A virus (IAV). The potential targets signaling pathways IAV...