A5011524762- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Breast Implant and Reconstruction
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Intracranial Aneurysms: Treatment and Complications
- Cancer Risks and Factors
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer and Skin Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Oral and Maxillofacial Pathology
Pusan National University
2024-2025
University of California, Irvine
2025
Chungnam National University Hospital
2025
National Cancer Center
2014-2024
Breast Cancer Research Foundation
2010-2022
Korea National Institute of Health
2009
University of Ulsan
1998-2006
Asan Medical Center
1998-2006
Ulsan College
2002-2004
Neurological Surgery
1999
Abstract Introduction Brain metastases (BM) occur in up to one third of patients with metastatic breast cancer (MBC), whose incidences and prognoses by subtypes BM have not been well delineated. Methods Retrospective survival analyses were performed 126 from 805 MBC treated at the National Cancer Center between August 2001 April 2006, according clinical characteristics, subtypes, receipt trastuzumab. Estrogen receptor (ER), progesterone (PR), human epidermal growth receptor-2 (HER2) statuses...
Aims The prognosis of metaplastic breast cancer (MBC) is reportedly worse than that triple-negative invasive ductal carcinoma (TN-IDC), but the determinants poor are not yet known. Methods Patients from two Korean centres were included in this study (67 MBC and 520 TN-IDC). Characteristics disease groups, including clinical parameters, histological features, chemoresponsiveness, recurrence survival estimates, evaluated. Results presented with larger tumours, more frequent distant metastasis...
Several in vitro studies have suggested the effects of adipokines and insulin resistance on breast cancer cell proliferation survival. However, little is known about clinical significance these findings. We examined associations between recurrence adiponectin, leptin, resistance, metabolic syndrome (MetS) a cohort 747 patients from 2001 to 2004. Adjusted hazard ratios showed an inverse trend across quartiles for serum adiponectin concentration estrogen receptor (ER)/progesterone (PR)...
While the inflammatory cytokine interleukin-18 (IL-18) is known to activate natural killer (NK) cells, its precise role in cancer controversial. In this study, we investigated of tumor-derived IL-18 on peripheral blood NK cells breast patients.In cell lines, was expressed and secreted triple-negative (TNBC) lines MDA-MB-231 HCC-70 but not MCF-7 cells. The immature non-cytotoxic CD56dimCD16dim/- fraction increased following co-culture with increase observed tumor transfected siRNA for or...
Goserelin and letrozole in premenopausal patients can result clinical outcomes comparable to those obtained by alone postmenopausal with metastatic breast cancer (MBC).A total of 73 hormone-responsive MBC were included. Of those, 35 received goserelin (3.6 mg subcutaneously every 28 days) plus (2.5 orally daily), 38 as their first-line endocrine therapy a setting.Baseline characteristics similar the two groups, except for younger age (median, 41 v 53.5 years; P < .001) shorter disease-free...
Abstract Background Although the invasive lobular carcinoma (ILC) is second most frequent histologic subtype in Western countries, its incidence much lower Asia, and characteristics are less well known. Methods We assessed clinical outcomes of 83 Korean patients (2.8%) with ILC for comparison 2,833 (97.2%) ductal (IDC), including 1,088 (37.3%) luminal A (LA-IDC). Results The mean age all was 48.2 years, no significant differences among groups. Compared to IDC, showed a larger tumor size...
The heterogeneity of triple-negative breast cancer (TNBC) poses difficulties for suitable treatment and leads to poor outcome. This study aimed define a consensus molecular subtype (CMS) TNBC thus elucidate genomic characteristics relevant therapy. We integrated the expression profiles 957 samples from published datasets. identified by exploring pathway activity, microenvironment, clinical relevance. In addition, drug response (DR) scores (n = 181) were computationally investigated using...
: Autoimmune hemolytic anemia (AIHA) is rare and characterized by with a positive direct antiglobulin test result after the exclusion of other causes. While adults often relapse within 1 year first-line steroid therapy, children generally respond well. However, current treatment approaches lack substantial evidence are primarily expert opinion-based. This study aimed to contribute our single-center experience pediatric AIHA guidelines. Between January 2012 June 2024, 475 were diagnosed...
Immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) are reliable ways to identify overexpression or amplification of the HER-2/neu (HER2, symbol ERBB2) gene, but each technique requires a high-quality tissue sample, which may not be available. We investigated whether serum concentrations HER2 extracellular domain (ECD) can used as an alternative status metastatic breast cancer, we defined optimal decision-level concentration for prediction status.In 195 patients with...