A5001321686- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Crystallization and Solubility Studies
- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
- Advanced Biosensing Techniques and Applications
- Botanical Research and Chemistry
- Advanced biosensing and bioanalysis techniques
- Legume Nitrogen Fixing Symbiosis
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
Carnegie Mellon University
2014
National Chemical Laboratory
2009
Abstract The combination of polymers with nucleic acids leads to materials significantly advanced properties. To obviate the necessity and complexity conjugating two macromolecules, a polymer initiator is described that can be directly covalently linked DNA during solid‐phase synthesis. Polymer then grown from bound initiator, both in solution after DNA‐initiator released solid support as well on support, simplifying purification. resulting polymer‐DNA hybrids were examined by chromatography...
Protein-polymer hybrids (PPHs) represent an important and rapidly expanding class of biomaterials. Typically in these the linkage between protein polymer is covalent. Here we describe a straightforward approach to noncovalent PPH that mediated by DNA. Although noncovalent, DNA-mediated affords highly specific pairing assembly properties To obtain protein-DNA conjugate for PPH, report here first direct copper catalyzed azide-alkyne cycloaddition-based conjugation. This significantly...
Abstract The combination of polymers with nucleic acids leads to materials significantly advanced properties. To obviate the necessity and complexity conjugating two macromolecules, a polymer initiator is described that can be directly covalently linked DNA during solid‐phase synthesis. Polymer then grown from bound initiator, both in solution after DNA‐initiator released solid support as well on support, simplifying purification. resulting polymer‐DNA hybrids were examined by chromatography...
A highly divergent route to a variety of quinolizidine alkaloids is described. The enantiomeric precursors 22a and 22b utilized for the synthesis these were constructed stereospecifically from PET cyclization corresponding acetylene tethered α-trimethylsilyl amine moieties 21a 21b, respectively, both which synthesised D-ribose. polyhydroxy alkaloid 7 was found be selective inhibitor α-galactosidase with Ki 83.9 μM. analogs 18, 12 10 are potent inhibitors α-glucosidase 28, 120 140 μM, respectively.