Background. Respiratory syncytial virus (RSV) has been implicated in the etiology of adult community-acquired pneumonia (CAP). We investigated RSV infection Chilean adults with CAP using direct viral detection, real-time reverse-transcription polymerase chain reaction (rtRT-PCR), and serology (microneutralization assay). Methods. RSV, other respiratory viruses, bacteria were studied by conventional molecular techniques aged ≥18 years presenting to healthcare facilities Santiago, Chile from...

OnabotulinumtoxinA (OnabotA) is effective in Chronic Migraine (CM) during first year of treatment and longer. In real clinical setting, CM patients with acute Medication Overuse (MO) or concurrently receiving oral preventatives are treated OnabotA. We aim to assess evolution beyond on Data were retrospectively collected three headache units. analyzed cases who had received at least five sessions OnabotA according PREEMPT protocol. continued therapy when a reduction number days 30% was...

OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) after publication PREEMPT trials. Thus, we set out to evaluate the efficacy OnabotA in a series patients with CM treated according protocol. In May 2012 began offer who did not respond topiramate and at least one other preventive therapy (beta blocker and/or calcium channel antagonist). We prospectively recorded demographic data characteristics migraine, assessed modifications monthly headache days, as well...

Implantable loop recorders (ILR) may allow detection of occult paroxysmal atrial fibrillation (PAF) in patients with cryptogenic ischemic stroke. However, optimal selection algorithm and ideal duration monitoring remain unclear. AIM. To determine the incidence time-profile PAF stroke studied Reveal XT ILR, who were selected based on a high suspicion cerebral embolism.absence etiology after complete study including vascular imaging, transesophageal echocardiography at least 24 hours cardiac...

Introduction: Supraorbital neuralgia (SON) is an uncommon disorder characterized by pain in the area supplied supraorbital nerve, which covers medial aspect of forehead, together with tenderness over notch or along course nerve. Few hospital-based series non-trauma SON have been published. Methods and results: We prospectively analyzed 13 patients (11 females, two males) diagnosed a headache outpatient clinic four-year period. Background was mostly dull moderate intensity. In addition, nine...

Some variables have been proposed as predictors of efficacy OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence single nucleotide polymorphisms response OnabotulinumtoxinA. included 156 female patients treated with accordingly PREEMPT paradigm three headache units. was offered that had not responded topiramate and at least one other preventative. Age first procedure 43.7 ± 11.8 years (16–74). Patients a reduction 50% number...

Objective To investigate differences in topographical pressure pain sensitivity maps of the scalp between patients with migraine and healthy controls considering chronicity (episodic/chronic) side (strictly unilateral/bilateral) symptoms. Background It seems that trigeminal area is sensitized migraine. No study has investigated Methods Pressure thresholds (PPTs) were assessed from 21 points distributed over 86 episodic migraine, 76 chronic 42 age matched a blinded design. Topographical based...

Auriculotemporal neuralgia (ATN) is an infrequent syndrome consisting in strictly unilateral pain the temporal region associated with nerve tenderness, which can be successfully treated anesthetic blockade. We analysed clinical characteristics and treatment response a series of eight patients.Series consecutive patients diagnosed ATN at Headache Clinics two university hospitals Spain. Data on demographic characteristics, as well to are presented.Eight (seven women). Mean age onset was 52.8 ±...

Migraine affects the daily life of millions people around world. The most well-known disabling symptom associated with this illness is intense headache. Nowadays, there are treatments that can diminish level pain. OnabotulinumtoxinA (BoNT-A) has become a very popular medication for treating migraine headaches in those cases which other not working, typically chronic migraines. Currently, positive response to Botox treatment clearly understood, yet understanding mechanisms determine...

Abstract Background Nummular headache (NH) is most commonly a localized unifocal headache; however, some patients infrequently exhibit multifocal symptomatic painful head areas retaining all features of NH. We present the pressure pain sensitivity map an adolescent with Case presentation describe case 14 year-old-girl 3-year history continuous in four rounded areas, them same size and shape. Pressure thresholds (PPT) were assessed on 21 points over scalp areas. A was constructed. The...

Epicrania fugax (EF) is a novel syndrome presenting with brief pain paroxysms that always start in particular area of the head to spread immediately either forward or backward. Paroxysms stem from focal area, which well-shaped continuous reminiscent symptomatic described nummular headache (NH) can be present. We aimed analyze association these two epicranial headaches eight patients.We prospectively assessed all patients EF attending an outpatient office March 2008, when was first described,...

A peripheral mechanism has been proposed for nummular headache; however, there have descriptions of atypical features resembling migraine. The authors describe a case in which algometry assessment facilitated the discrimination between headache and circumscribed 21-year-old woman presented with history focal episodic pain area on left frontal region. study showed unilateral diffuse decrease pressure thresholds predominance, as migraine patients. This result led to introduce more specific...

Abstract The major digestive proteinase activities of a new sugar beet pest, Aubeonymus mariaefranciscae Roudier (Coleoptera: Curculionidae), were characterized. Both larvae and adults A. found to use complex proteolytic system for protein digestion based on at least trypsin‐, chymotrypsin‐, elastase‐, cathepsin D, leucine aminopeptidase‐, carboxypeptidase A‐ B‐like activities. An azocaseinolytic activity pH 5.0–7.0 was identified, that not affected by specific inhibitors activators, making...

Cuando tras una correcta anamnesis y exploración neurológica se diagnostica a un paciente con cefalea primaria o neuralgia craneofacial en urgencias atención decide derivar neurología por complejidad es útil conocer si además deberían solicitar exploraciones complementarias la preferencia (urgente, preferente normal) que debería para el llegue consulta del neurólogo sin demoras innecesarias pacientes dolores incapacitantes sospecha de organicidad. Por este motivo, Grupo Estudio Cefalea...

Introduction . Familial hemiplegic migraine (FHM) is a rare disorder characterized by attacks with motor weakness during the aura phase. Mutations in CACNA1A, ATP1A2, SCN1A, and PRRT2 genes have been described. Methods To describe mutation ATP1A2 gene FHM case especially severe prolonged symptomatology. Results 22-year-old woman was admitted due to migraine-type headache sudden onset of right-sided aphasia; she had similar episodes her childhood. Her mother diagnosed without genetic...

Previous studies suggest that trigger points (TrPs) contribute to migraine pain, but no data is available on the effects of TrPs pressure pain sensitivity. Our objective was investigate association between number and widespread hypersensitivity in women with episodic migraines.Ninety-five migraines participated. Clinical features migraines, is, intensity, duration, frequency, onset, were collected. Active latent bilaterally explored temporalis, masseter, suboccipital, sternocleidomastoid,...

Objectives/Background We analyzed characteristics of hypnic headache ( HH ), migraine and the relationship between both headaches in 23 patients. is an uncommon primary characterized by exclusively sleep‐related attacks. Concurrence other headaches, mainly migraine, has been reported, but syndromes rarely considered. Methods prospectively collected data a outpatient office from J anuary 2008 to S eptember 2013. Demographic mean features were assessed. Results Twenty‐three out 2500 (0.92%)...