A5054437542- Curcumin's Biomedical Applications
- Ginger and Zingiberaceae research
- Phytochemistry and biological activities of Ficus species
- Connexins and lens biology
- Silicon Carbide Semiconductor Technologies
- Liver Disease Diagnosis and Treatment
- Seed and Plant Biochemistry
- Chemotherapy-induced cardiotoxicity and mitigation
- Papaya Research and Applications
- Bone Metabolism and Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Saffron Plant Research Studies
- Liver Disease and Transplantation
- Genomics, phytochemicals, and oxidative stress
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
Benha University
2022-2025
Mutah University
2023-2025
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management DR. Exosomes, considered promising cell-free therapy option, display biological functions similar to those their parent cells. In retinal development, Wnt/b-catenin signaling provides key cues functional progression. The present study aimed evaluate the potential efficacy bone marrow-derived mesenchymal cell-derived...
ABSTRACT Food preservatives can break food safety worldwide; herein, we studied the mitigating effect of Ficus carica (FC) on hepato‐renal injury resulting from monosodium glutamate (MSG) or metanil yellow (MY) as a common preservative. Rats were assigned into five groups; Control, MSG (400 mg/kg), MY (200 FC+MSG (received FC plus MSG), and FC+MY group MY). The antioxidant properties evaluated. results revealed potency leave extract. MSG/MY evoked indicated by marked elevations in their...
Hepatic fibrosis is a common pathology present in most chronic liver diseases. Autophagy lysosome-mediated intracellular catabolic and recycling process that plays an essential role maintaining normal hepatic functions. Nuclear factor erythroid 2-like 2 (Nrf2) transcription responsible for the regulation of cellular anti-oxidative stress response. This study was designed to assess cytoprotective effect mesenchymal stem cell-derived exosomes (MSC-exos) on endothelial-mesenchymal transition...
Aflatoxin B1 (AFB1) is a common environmental pollutant that poses major hazard to both humans and animals. Acacia senegal (Gum) well-known for having antioxidant anti-inflammatory bioactive compounds. Our study aimed scout the nephroprotective effects of gum against AFB1-induced renal damage. Four groups rats were designed: Control, Gum (7.5 mg/kg), AFB1 (200 µg/kg b.w) AFB1-Gum, co-treated with AFB1. Gas chromatography-mass spectrometry (GC/MS) analysis was done determine phytochemical...
Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play crucial role in cell-cell communication have efficacy the treatment various diseases. In study, we aim to investigate cardioprotective...
Background: Osteoporosis (OP) is a disease characterized by decreased bone mass and widely recognized as major health problem.Flutamide an androgen receptor blocker used in treatment of cancer prostate.Its prolonged use usually associated with OP which now treated bisphosphonates.Aim: this work was designed to explore the potential benefit forskolin (a cAMP/protein kinase A pathway stimulant) alone combination alendronate on flutamide -induced osteoporosis rats.Subjects methods: Forskolin 6...