A5101552777- Energetic Materials and Combustion
- Rocket and propulsion systems research
- Inflammatory mediators and NSAID effects
- Chemical Reactions and Mechanisms
- Thermal and Kinetic Analysis
- Synthesis and biological activity
- Advanced Chemical Physics Studies
- Tribology and Lubrication Engineering
- Algal biology and biofuel production
- Fluorine in Organic Chemistry
- Antimicrobial Peptides and Activities
- Oil Spill Detection and Mitigation
- Luminescence Properties of Advanced Materials
- Inorganic Fluorides and Related Compounds
- Crystallography and molecular interactions
- RNA modifications and cancer
- Molecular Spectroscopy and Structure
- Microbial Natural Products and Biosynthesis
- Synthesis and Reactions of Organic Compounds
- Marine and coastal ecosystems
- Microbial Metabolites in Food Biotechnology
- Synthesis and Biological Evaluation
- Genetics, Bioinformatics, and Biomedical Research
- Mass Spectrometry Techniques and Applications
- Synthesis of heterocyclic compounds
Wuhan University
2013-2022
Aerospace Research Institute of Materials and Processing Technology
2019
South Central Minzu University
2017
Beijing Institute of Technology
2015-2017
Beijing Haidian Hospital
2014
Pfizer (United States)
2000
Series of 1,2-diarylpyrroles has been synthesized and found to contain very potent selective inhibitors the human cyclooxygenase-2 (COX-2) enzyme. The paper describes short practical syntheses target molecules utilizing Paal−Knorr reaction. Electrophilic substitution on 1 proceeds in a regioselective fashion, method was used generate number tetrasubstituted pyrroles. Detailed SAR series studied by modifications aryl rings substituents pyrrole ring. Diarylpyrrole is (COX-2, IC50 = 60 nm)...
A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent highly selective (1000-9000-fold) inhibitors the human COX-2. 3-Pyridyl derived COX-2 inhibitor (25) exhibited excellent activity in acute (carrageenan induced paw edema, ED(50) = 5.4 mg/kg) chronic (adjuvant arthritis, 0.25 models inflammation. The relatively long half-life 25 rat dog prompted investigation pyridyl other heteroaromatic systems containing potential metabolic functionalities....
A new family of high performance, nitrogen-rich energetic salts containing <italic>N</italic>,<italic>N</italic>′-azo linkage were synthesized through the protonation 3,3′-diamino-4,4′-azobis-1,2,4-triazole.
The coupling of primary piggery wastewater as a culture medium with elevated CO2 aeration is thought to be an economically feasible option for the cultivation microalgae. However, little information available regarding photosynthetic characteristics microalgae and nutrient removal from at different concentrations. It was found that provided sustained growth concentrations ranging 5% 15% performed best in Chlamydomonas reinhardtii growth. Photosynthesis, respiration, uptake (total nitrogen...
The role of counterions N<sub>5</sub><sup>+</sup>-containing salts in stabilizing N<sub>5</sub><sup>+</sup> cations was studied by means density functional theory.
Novel [NF<sub>2</sub>O]<sup>+</sup> and [N<sub>3</sub>NF<sub>2</sub>O]<sup>+</sup>-based energetic oxidizers show super high specific impulses with thermal stabilities synthesis possibilities, which may be used as a potential new generation of solid propellants.
Flue gas from power plants can promote algal cultivation and reduce greenhouse emissions(1). Microalgae not only capture solar energy more efficiently than plants(3), but also synthesize advanced biofuels(2-4). Generally, atmospheric CO2 is a sufficient source for supporting maximal growth(5). On the other hand, high concentrations of in industrial exhaust gases have adverse effects on physiology. Consequently, both conditions (such as nutrients light) control flue flow into...
Fluorine atoms and four-membered rings form 3,3′-difluoroazetidinium (DFAZ) salts, which have a better detonation property than ammonium dinitramide (ADN).
Abstract Thermal stabilities of the N 5 + M ‐ species (M: Sb(OH) 6 , 4 F 2 AlF BF B(CF 3 ) PF AsF and SbF are studied by DFT calculations using Gaussian 09 package.