A5027781823- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Aortic Thrombus and Embolism
- Infectious Aortic and Vascular Conditions
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Health Systems, Economic Evaluations, Quality of Life
- Spinal Cord Injury Research
- Cardiovascular Issues in Pregnancy
Washington University in St. Louis
1995-2024
Missouri Baptist Medical Center
2014-2023
Columbia University
2023
Master's College
2023
BJC HealthCare
2003-2022
San Diego Cardiac Center
2004-2020
English Heritage
2015-2017
Active Technologies (Italy)
2015-2017
Public Policy Institute of California
2015-2017
Clinical Research Institute
2001-2016
Coronary artery bypass graft (CABG) surgery with autologous vein grafting is commonly performed. Progressive neointimal hyperplasia, however, contributes to considerable failure. Edifoligide an oligonucleotide decoy that binds and inhibits E2F transcription factors thus may prevent hyperplasia failure.To assess the efficacy safety of pretreating grafts edifoligide for patients undergoing CABG surgery.A phase 3 randomized, double-blind, placebo-controlled trial 3014 primary at least 2 planned...
To examine the question of why pacing rate and duration atrial are crucial factors in successful interruption flutter, studies were performed on 30 patients period following open heart surgery. In each patient diagnosis flutter was made using a pair wire electrodes placed right epicardium at time operation brought out through anterior chest wall. The same used for pacing. Pacing faster than spontaneous which failed to interrupt associated with transient entrainment up rate. Atrial...
During a 16-year interval ending in October 1990, 168 patients underwent 172 aortic root replacements. Thirty (18%) had Marfan syndrome. Annuloaortic ectasia (81 patients) and dissection (63 were the principal indications for operation. Twenty-seven (16%) previous operations on ascending aorta or valve. The hospital mortality rate was 5% duration of cardiopulmonary bypass only significant independent predictor early death (p = 0.017). Major modifications technique made 1981, when...
Vein-graft harvesting with the use of endoscopy (endoscopic harvesting) is a technique that widely used to reduce postoperative wound complications after coronary-artery bypass grafting (CABG), but long-term effects on rate vein-graft failure and clinical outcomes are unknown.
It is essential that the medical profession play a central role in critically evaluating evidence related to drugs, devices, and procedures for detection, management, or prevention of disease. Properly applied, rigorous, expert analysis available data documenting absolute relative benefits risks these therapies can improve outcomes reduce costs care by focusing resources on most effective strategies. One important use such production clinical practice guidelines which, turn, provide...
The nature of localized atrial activation during fibrillation was characterized in 34 patients following open heart surgery. Bipolar electrograms (AEG) recorded each patient with exhibited a myriad sizes, shapes, polarities, amplitudes, and beat‐to‐beat intervals. On the basis AEG morphology its baseline, we have classified recordings into four Types. Type I by discrete complexes separated an isoelectric baseline free perturbation, II but perturbations between complexes, III AEGs which...
Background— Coronary artery bypass grafting success is limited by vein graft failure (VGF). Understanding the factors associated with VGF may improve patient outcomes. Methods and Results— We examined 1828 participants in Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) trial undergoing protocol-mandated follow-up angiography 12 to 18 months post–coronary or earlier clinically driven angiography. Outcomes included patient- graft-level angiographic (≥75% stenosis...
The optimal substitute for severely diseased aortic valves in children and young adults is unknown. use of a mechanical prosthesis requires permanent treatment the patient with anticoagulants associated thromboembolic hemorrhagic complications. Aortic-valve allografts porcine bioprostheses, which do not necessitate anticoagulant therapy, may deteriorate have limited durability.
in 1988, [1] followed by a revised version 1996 [2], valvular heart surgery has evolved to include an enhanced understanding of patient-and disease-related factors affecting outcomes, increased numbers valve repairs, more operations performed for patients with minimal symptoms, new prostheses, novel repair methods, and the emergence percutaneous interventional (catheter-based) replacement.To adapt this changing environment, Councils American Association Thoracic Surgery, The Society...
The cause of cerebral and peripheral embolism remains undetermined in a significant number patients. An atherosclerotic thoracic aorta has thus far been considered to be an uncommon one.To define the potential role ascending as embolic source, intraoperative ultrasonic aortic imaging was performed 1200 1334 consecutive patients aged 50 years older who were undergoing cardiac surgery. Patients divided into two groups according results ultrasound study terms presence or absence disease....