A5023886082- Vibrio bacteria research studies
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Data-Driven Disease Surveillance
- Hepatitis C virus research
- Zoonotic diseases and public health
- Child Nutrition and Water Access
- Urinary Tract Infections Management
- COVID-19 diagnosis using AI
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Immune responses and vaccinations
- Food Safety and Hygiene
- Bacterial Identification and Susceptibility Testing
- Cassava research and cyanide
- SARS-CoV-2 detection and testing
- Nutrition and Health in Aging
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Escherichia coli research studies
University College London
2025
Pennsylvania State University
2020-2025
Center for Disease Dynamics, Economics & Policy
2020-2025
MRC Unit for Lifelong Health and Ageing
2025
Agence de Médecine Préventive
2016-2018
Institut Pasteur
2015-2016
Institut de Veille Sanitaire
2015-2016
Abstract Social disadvantage, like advanced age, is a risk factor for broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using multicohort approach, we investigated associations social disadvantage with age-related plasma proteins and diseases. We found proteomic signatures accelerated immune 14 specific linked to during both early later life. Individuals experiencing had an increased 66 diseases, up 39% these mediated by (for example,...
SUMMARY Two community-based density case-control studies were performed to assess risk factors for cholera transmission during inter-peak periods of the ongoing epidemic in two Haitian urban settings, Gonaives and Carrefour. The strongest associations were: close contact with patients (sharing latrines, visiting patients, helping someone diarrhoea), eating food from street vendors washing dishes untreated water. Protective drinking chlorinated water, receiving prevention messages via...
Cholera is a bacterial water-borne diarrheal disease transmitted via the fecal-oral route that causes high morbidity in sub-Saharan Africa and Asia. It preventable with vaccination, Water, Sanitation, Hygiene (WASH) improvements. However, impact of vaccination endemic settings remains unclear. city Kalemie, on shore Lake Tanganyika, Democratic Republic Congo, where both seasonal mobility lake, potential environmental reservoir, may promote transmission. Kalemie received campaign WASH...
<title>Abstract</title> <bold>Background</bold> Providing non-invasive, accurate and affordable SARS-CoV-2 tests represents a public health priority, to better control viral circulation while protecting healthcare workers. Saliva is robust alternative nasopharyngeal (NP) swab, but there heterogeneity in collection pre-analytical methods. <bold>Methods</bold> Relying on national COVID-19 Public Health Programme, we prospectively recruited 3,488 symptomatic asymptomatic adults attending the...
Abstract Objective To assess the performance of SD Bioline Cholera Ag O1/O139 rapid diagnostic test ( RDT ) compared to a reference standard combining culture and PCR for diagnosis cholera cases during an outbreak. Methods bacterial were performed on site using fresh stools collected from suspected cases, enriched in alkaline peptone water. Dried stool samples filter paper tested V. cholerae by Lusaka (as part laboratory technology transfer project) at Paris, France. A sample was considered...
Introduction Oral cholera vaccines are primarily recommended by the World Health Organization for control in endemic countries. However, number of currently produced is very limited and examples OCV use countries, especially urban settings, scarce. A vaccination campaign was organized Médecins Sans Frontières Ministry a highly area Democratic Republic Congo. This study aims to describe vaccine coverage achieved with this targeted acceptability among vaccinated communities. Methods findings...
Abstract Background Population-representative household survey methods require up-to-date sampling frames and sample designs that minimize time cost of fieldwork especially in low- middle-income countries. Traditional such as multi-stage cluster sampling, random-walk, or spatial can be cumbersome, costly inaccurate, leading to well-known biases. However, a new tool, Epicentre’s Geo-Sampler program, allows simple random structures, which eliminate some these We describe the study design...
Cholera is endemic in Guinea, having suffered consecutive outbreaks from 2004 to 2008 followed by a lull until the 2012 epidemic. Here we describe temporal-spatial and behavioural characteristics of cholera cases Conakry during three-year period, including large-scale We used national African Surveillance Network (Africhol) surveillance data collected every treatment centre city August 2011 December 2013. The prevalence suspect confirmed cases, case fatality ratio (CFR), factors associated...
In April 2016, an emergency vaccination campaign using one dose of Oral Cholera Vaccine (OCV) was organized in response to a cholera outbreak that started Lusaka February 2016. December second round conducted, with the objective increasing duration protection, before high-risk period for transmission. We assessed coverage first and rounds OCV campaign.Vaccination estimated after each from sample selected targeted-areas cross-sectional survey establish status individuals recruited. The study...
Human movement and population connectivity inform infectious disease management. Remote data, particularly mobile phone usage are frequently used to track mobility in outbreak response efforts without measuring representation target populations. Using a detailed interview instrument, we measure ownership, mobility, access healthcare highly with low health care Namibia, middle-income country. We find that 1) ownership is both biased by gender, 2) correlated differences healthcare, 3)...
The fifth annual meeting of the African cholera surveillance network (Africhol) took place on 10-11 June 2015 in Lomé, Togo. Together with international partners, representatives from 11 member countries -Cameroon, Côte d'Ivoire, Democratic Republic Congo, Guinea, Kenya, Mozambique, Nigeria, Tanzania, Togo, Uganda, Zimbabwe- and an invited country (Malawi) shared their experience. featured three sessions: i) surveillance, prevention control participating countries, ii) methodology, such as...
Abstract We conducted a matched case-control (MCC), test-negative (TNCC) and case-cohort study in 2016 Lusaka, Zambia, following mass vaccination campaign. Confirmed cholera cases served as all three designs. In the TNCC, control-subjects were with negative culture polymerase chain reaction results. Matched controls by age sex selected among neighbours of confirmed MCC study. For study, we recruited cohort randomly individuals living areas considered at-risk cholera. 211 suspected (66 145...
SUMMARY Streptococcus pneumoniae (Spn) is a leading cause of community-acquired pneumonia (CAP), yet existing diagnostic tools remain inadequate. We aimed to evaluate laboratory and radiological methods for detecting pneumococcal aetiology in CAP patients estimate Spn prevalence this group. All-aged hospitalized with clinically defined northern Togo were enrolled during 2010–2013. Latent class analysis pooled results semi-automated blood culture (SABC), whole lytA real-time polymerase chain...
Measles continues to circulate in the Democratic Republic of Congo, and country suffered from several important outbreaks over last 5 years. Despite a large outbreak starting former province Katanga 2010 resulting immunization activities, another occurred 2015 this same region. We conducted measles seroprevalence surveys four health zones (HZ) Province order assess immunity against children 6 months 14 years after outbreak. multi-stage cluster stratified by age group HZs, Kayamba,...
Oral cholera vaccine (OCV) has increasingly been used as an outbreak control measure, but shortages limit its application. A two-dose OCV campaign targeting residents aged over 1 year was launched in three rural Communes of Southern Haiti during following Hurricane Matthew October 2016. Door-to-door and fixed-site strategies were employed mobile teams delivered vaccines to hard-to-reach communities. This the first use recently pre-qualified OCV, Euvichol. The study objective estimate...
(Abstracted from Lancet 2016;387:1531–1539) French Polynesia suffered one of the largest outbreaks Zika virus between October 2013 and April 2014 with over 32,000 patients being assessed for infection. A few studies have reported a simultaneous occurrence Guillain-Barré syndrome in Brazil, suggesting an association 2.
Measles is a major cause of child mortality in sub-Saharan Africa. Current immunization strategies achieve low coverage areas where transmission drivers differ substantially from those high-income countries. A better understanding measles with persistence will increase vaccination and reduce ongoing transmission. We analysed weekly reported cases at the district level Niger 1995 to 2004 identify underlying mechanisms. identified dominant periodicities associated spatial clustering patterns....