A5070261058- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Hippo pathway signaling and YAP/TAZ
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
- Signaling Pathways in Disease
Nagoya City University
2016-2025
Japanese Foundation For Cancer Research
2008-2011
The Cancer Institute Hospital
2010-2011
Japan Science and Technology Agency
2007-2010
KAN Research Institute
2007
Abstract The retinoblastoma tumor suppressor protein (Rb) is mutated or expressed at very low levels in several types, including and osteosarcoma, as well small cell lung, colon, prostate, bladder, breast carcinomas. Loss reduction of Rb expression seen most commonly high-grade adenocarcinomas, suggesting that a relationship may exist between loss function less-differentiated state, increased proliferation, high metastatic potential. In this study, we found knockdown by interfering RNA MCF7...
TGFβ is involved in various biological processes, including development, differentiation, growth regulation, and epithelial-mesenchymal transition (EMT). In TGFβ/Smad signaling, receptor-activated Smad complexes activate or repress their target gene promoters. cofactors are a group of Smad-binding proteins that promote recruitment to these Long noncoding RNAs (lncRNA), which behave as cofactors, have thus far not been identified. Here, we characterize novel lncRNA EMT-associated induced by...
Abstract Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for suppression early stages. However, mechanism functional switching TGF-β is still unknown, and it unclear whether inhibition results amelioration or exacerbation cancers. Here we show that suppressor p53 cooperates with Smad proteins, which are signal transducers, to selectively activate plasminogen activator inhibitor type-1...
Abstract Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting degradation of molecules to prevent excessive activation signaling. Though Smurf2 has been shown negatively TGF-β/Smad signaling, its involvement BMP/Smad metabolism not thoroughly investigated. In the present study, we sought evaluate role Absorbable collagen sponges...
Chromosomal amplification occurs frequently in solid tumors and is associated with poor prognosis. Several reports demonstrated the cooperative effects of oncogenic factors same amplicon during cancer development. However, functional correlation between remains unclear. Transforming growth factor (TGF)-beta signaling plays important roles cytostasis normal epithelium differentiation, alterations TGF-beta have been identified many malignancies. Here, we that transcriptional co-repressors...
Ubiquitin-dependent protein degradation is involved in various biological processes, and accumulating evidence suggests that E3 ubiquitin ligases play important roles cancer development. Smad regulatory factor 1 (Smurf1) Smurf2 are ligases, which suppress transforming growth factor-beta (TGF-beta) family signaling through of Smads receptors for TGF-beta bone morphogenetic proteins. In addition, Smurf1 has been reported to promote RhoA ubiquitination regulate cell motility, suggesting the...
Kurarinone, a flavonoid isolated from the roots of Sophora flavescens, was suggested to exert potent antioxidant and immunosuppressive effects. However, underlying mechanisms remain unclear. Nuclear factor erythroid 2-related 2 (Nrf2) is key transcription that regulates defense system with anti-inflammatory activity. In present study, we demonstrated kurarinone activated Nrf2 increased expression enzymes, including heme oxygenase-1 (HO-1). Mechanistically, downregulated kelch-like...
Abstract The introduction of novel treatments for multiple myeloma (MM), particularly proteasome inhibitors (PIs) such as bortezomib (BTZ), has significantly improved patient outcomes. However, many patients eventually relapse, underscoring the urgent need new therapeutic strategies to overcome PI resistance. integrated stress response (ISR) is a conserved intracellular signaling network activated by various intrinsic and extrinsic stressors. This mediated four specialized kinases, HRI,...
Background Mechanical stress rapidly induces ΔFosB expression in osteoblasts, which binds to interleukin (IL)-11 gene promoter enhance IL-11 expression, and enhances osteoblast differentiation. Because bone morphogenetic proteins (BMPs) also stimulate there is a possibility that BMP-Smad signaling involved the enhancement of differentiation by mechanical stress. The present study was undertaken clarify whether affects signaling, if so, elucidate role Smad stress-induced transcription....
The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic death response to various cellular stresses, thereby preventing cancer development. Therefore, the activation of through small molecules is an attractive therapeutic strategy for treatment cancers retaining wild-type p53. We used a library 700 Myanmar wild plant extracts identify that induce transcriptional activity. A cell-based screening method with p53-responsive luciferase-reporter assay system revealed...
Tribbles 1 (TRB1) is one of the mammalian orthologs Drosophila Tribbles, which regulates development and cell proliferation. TRB1 suggested to act as a scaffold protein in signaling pathways for important cellular processes. has also been identified myeloid oncogenic driver mediates leukemogenesis through mitogen-activated extracellular kinase (MEK)/extracellular signal-regulated (ERK) pathway CCAAT/enhancer binding (C/EBP) transcriptional factors. However, physiological roles solid tumors...
Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20). SET8 has been implicated in regulation multiple biological processes, such as gene transcription, cell cycle, senescence. quickly undergoes ubiquitination degradation by several E3 ubiquitin ligases; however, deubiquitinates not yet identified. Here we demonstrated ubiquitin-specific peptidase 17-like family member (USP17) therefore...
Object. Cavernous sinus cavernomas are rare lesions associated with high rates of intraoperative mortality and morbidity resulting from profuse bleeding. In this paper, the authors report their experience in treating five patients histologically confirmed cavernous describe efficacy induced hypotension facilitating excision lesion. Methods. All were women ranging age 25 to 54 years, an average 42 years. The mass was small one large (> 3 cm diameter) four. patient a mass, cardiac arrest...