Resting-state functional connectivity (FC) analyses have shown atypical in autism spectrum disorder (ASD) as compared to typically developing (TD). However, this view emerges from investigating static FC overlooking the whole brain transient patterns. In our study, we investigated how age and disease influence dynamic changes of TD ASD. We used resting-state magnetic resonance imaging (rs-fMRI) data stratified into three cohorts: children (7-11 years), adolescents (12-17 adults (18+ years)...

Signal transmission in the brain propagates via distinct oscillatory frequency bands but aperiodic component, 1/f activity, almost always co-exists which most of previous studies have not sufficiently taken into consideration. We used a recently proposed parameterization model that delimits and components neural dynamics on lifespan aging data collected from human participants using magnetoencephalography (MEG). Since healthy underlines an enormous change local tissue properties, any...

Alzheimer's disease (AD) is a neurodegenerative disorder contributing to rapid decline in cognitive function and ultimately dementia. Most cases of AD occur elderly later years. There growing need for understanding the relationship between aging identify shared unique hallmarks associated with region cell-type specific manner. Although genomic studies on have been performed extensively, molecular mechanism progression still not clear. The major objective our study obtain higher-order...

Healthy ageing is accompanied by changes to spontaneous electromagnetic oscillations. At the macroscopic scale, previous studies have quantified basic features, e.g., power and frequencies in rhythms of interest from perspective attention, perception, learning memory. On other hand, signatures modes neural communication recently been argued be identifiable global measures applied on neuro-electromagnetic data such as coherence that quantifies degree togetherness distributed oscillations...

Spontaneous brain activity, that is, activity in the absence of controlled stimulus input or an explicit active task, is topologically organized multiple functional networks (FNs) maintaining a high degree coherence. These "resting state networks" are constrained by underlying anatomical connectivity between areas. They also influenced history task-related activation. The precise rules link plastic changes and ongoing dynamics resting-state (rs-FC) remain unclear. Using framework open source...

Previous computational models have related spontaneous resting-state brain activity with local excitatory-inhibitory balance in neuronal populations. However, how underlying neurotransmitter kinetics associated E-I govern dynamics remains unknown. Understanding the mechanisms by virtue of which fluctuations concentrations, a hallmark variety clinical conditions, relate to functional is critical importance. We propose multiscale dynamic mean field (MDMF) model-a system coupled differential...

Abstract We propose that the preservation of functional integration, estimated from measures neural synchrony, is a key objective neurocompensatory mechanisms associated with healthy human ageing. To support this proposal, we demonstrate how phase-locking at peak alpha frequency in Magnetoencephalography recordings remains invariant over lifespan large cohort participants, aged 18-88 years. Using empirically derived connection topologies diffusion tensor imaging data, create an in-silico...

Observable lip movements of the speaker influence perception auditory speech. A classical example this is reported by listeners who perceive an illusory (cross-modal) speech sound (McGurk-effect) when presented with incongruent audio-visual (AV) stimuli. Recent neuroimaging studies AV accentuate role frontal, parietal and integrative brain sites in vicinity superior temporal sulcus (STS) for multisensory perception. However, if how does network across whole participates during processing...

Abstract Temporally stable patterns of neural coordination among distributed brain regions are crucial for survival. Recently, many studies highlight association between healthy aging and modifications in organization functional networks, across various time-scales. Nonetheless, quantitative characterization temporal stability networks remains unexplored. This study introduces a data-driven unsupervised approach to capture high-dimensional dynamic connectivity (dFC) via low-dimensional...

A challenging problem in cognitive neuroscience is to relate the structural connectivity (SC) functional (FC) better understand how large-scale network dynamics underlying human cognition emerges from relatively fixed SC architecture. Recent modeling attempts point possibility of a single diffusion kernel giving good estimate FC. We highlight shortcomings single-diffusion-kernel model (SDK) and propose multi-scale scheme. Our formulated as reaction-diffusion system rise spatio-temporal...

Background: The socio-environmental aspects of southern Assam reflect a general pattern backwardness. Moreover, child healthcare resources in the region are inadequately used, leading to low vaccination coverage. Given this background, paper attempted comprehend wealth-based inequality full rural areas Assam. Methodology: Based on multistage cluster sampling approach, 360 children 12–23 months were selected from study area. To identify predictors child, non-linear model was estimated by...

Smart grid has evolved as the next generation power paradigm which enables transfer of real time information between utility company and consumer via smart meter advanced metering infrastructure (AMI). These facilitate many services for both, such automatic reading, demand side management, time-of-use (TOU) pricing. However, there have been growing security privacy concerns over systems, are built with both legacy operational technologies. Intrusion detection is a critical service alerting...

Abstract Visual dual-stream theory posits that two distinct neural pathways of specific functional significance originate from primary visual areas and reach the inferior temporal (ventral) posterior parietal (dorsal). However, there are several unresolved questions concerning fundamental aspects this theory. For example, is dissociation between ventral dorsal stream driven by features in input stimuli or it categorical differences visuoperceptual visuomotor functions? Is dual rigid...