A5010290112- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
Sun Yat-sen Memorial Hospital
2022-2023
Sun Yat-sen University
2022-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
Abstract The heterogeneity of cancer-associated fibroblasts (CAFs) might be ascribed to differences in origin. CD10 and GPR77 have been reported identify a chemoresistance-inducing CAF subset breast cancer. However, the precise mechanism for formation + CAFs remains unknown. In this study, we found that CCL18 expression was positively correlated with density cancer associated poor response chemotherapy. Moreover, secreted by tumor-associated macrophages (TAMs) activated phenotype normal...
Abstract The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8+ T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid sphingomyelinase activation ceramide generation....
<div>Abstract<p>The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8<sup>+</sup> T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid...
<p>Supplementary figures S1-S8 and tables S1-S6</p>
<div>Abstract<p>The therapeutic efficacy of chemotherapy is in part a result its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms escape the attack and blunt chemosensitivity. Herein, we report that through single-cell profiling microenvironment, identified subset CD161-overexpressing CD8<sup>+</sup> T enriched chemoresistant tumors. CD161 engagement repressed calcium influx cytolytic capacity acid...
<p>Supplementary figures S1-S8 and tables S1-S6</p>