A5040075184- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Folate and B Vitamins Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Psychosomatic Disorders and Their Treatments
- Chronic Lymphocytic Leukemia Research
- Health Sciences Research and Education
- Health Policy Implementation Science
- Biomarkers in Disease Mechanisms
- Restraint-Related Deaths
- Monoclonal and Polyclonal Antibodies Research
- Suicide and Self-Harm Studies
- Nursing Diagnosis and Documentation
- Glycosylation and Glycoproteins Research
Emma Kinderziekenhuis
2013-2019
University of Amsterdam
2015-2019
Sanquin
2019
Amsterdam UMC Location University of Amsterdam
2013-2017
Red blood cell (RBC) alloimmunization is a major complication of transfusion therapy in sickle disease (SCD). Identification high-risk patients hampered by lack studies that take the cumulative exposure into account. In this retrospective cohort study among previously non-transfused SCD Netherlands, we aimed to elucidate association between exposure, first and independent risk factors. A total 245 received 11 952 RBC units. Alloimmunization occurred 43 (18%), half them formed their...
Essentials The role of von Willebrand Factor (VWF) in the pathophysiology sickle cell disease is unclear. We assessed markers VWF during admission for vaso-occlusive crisis (VOC) and steady state. reactivity was higher VOC associated with inflammation neutrophil activation. Hyper-adhesive may promote disease.Background Endothelial activation plays a central vaso-occlusion (SCD), facilitating adhesive interactions circulating blood cells. Upon activation, various molecules are expressed,...
Summary Most sickle cell disease (SCD) patients rely on blood transfusion as their main treatment strategy. However, frequent poses the risk of alloimmunization. On average, 30% SCD will alloimmunize while other patient groups form antibodies less frequently. Identification genetic markers may help to predict which are at alloantibodies. The aim this study was evaluate whether variations in Toll‐like receptor pathway or genes previously associated with antibody‐mediated conditions red (RBC)...
Previous reports demonstrated that patients with sickle cell disease (SCD) experience pain on more than half of the observed days. Yet, these high incidences do not seem to match observations in our population. In this prospective cohort study, we aimed assess frequency and characteristics daily, self-reported among adult SCD Netherlands. Consecutive were enrolled during routine outpatient visits followed up 6 months. A total 55 completed 5,982 diary observation Median age was 27 years (IQR...