A5023934391- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Enterobacteriaceae and Cronobacter Research
- Pneumonia and Respiratory Infections
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Mycobacterium research and diagnosis
- Infections and bacterial resistance
- Bacteriophages and microbial interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Yersinia bacterium, plague, ectoparasites research
- Systemic Lupus Erythematosus Research
- Dental Research and COVID-19
State Research Center for Applied Microbiology and Biotechnology
2018-2023
Siberian Branch of the Russian Academy of Sciences
2023
Institute of Chemical Biology and Fundamental Medicine
2023
Novosibirsk State University
2023
Klebsiella pneumoniae, a member of the ESKAPE group bacterial pathogens, has developed multi-antimicrobial resistance (AMR), including to carbapenems, which increased alarmingly due acquisition carbapenemase genes located on specific plasmids. Four clinical K. pneumoniae isolates were collected from four patients neuro-intensive care unit in Moscow, Russia, during point prevalence survey. The AMR phenotype was estimated using Vitec-2 instrument, and whole genome sequencing (WGS) done...
The purpose of this study was the identification genetic lineages and antimicrobial resistance (AMR) virulence genes in Klebsiella pneumoniae isolates associated with severe infections neuro-ICU. Susceptibility to antimicrobials determined using Vitek-2 instrument. AMR genes, sequence types (STs), capsular were identified by PCR. Whole-genome sequencing conducted on Illumina MiSeq platform. It shown that K. ST14K2, ST23K57, ST39K23, ST76K23, ST86K2, ST218K57, ST219KL125/114, ST268K20,...
Acinetobacter baumannii is one of the significant healthcare-associated meningitis agents characterized by multidrug resistance and a high mortality risk. Thirty-seven A. strains were isolated from thirty-seven patients Moscow neuro-ICU with in 2013–2020. The death rate was 37.8%. Strain susceptibility to antimicrobials determined on Vitek-2 instrument. Whole-genome sequencing conducted using Illumina technology; sequence types (ST), capsular (KL), lipooligosaccharide outer core locus (OCL),...
Aims: The objective of this study was phenotypic and genotypic characterization antibacterial-resistant Klebsiella pneumoniae clinical strains isolated in Moscow Transplantology Intensive Care Unit 2017–2019. Results: Major among K. (n = 63) from 30 patients were recognized as extensive drug-resistant 55) pathogens, remaining multidrug-resistant 8) pathogens. beta-lactamase genes blaSHV-1,-2a,-11,-27,-67,-187 63), blaCTX-M-14,-15 61), blaTEM-1 54), blaOXA-48 52), blaNDM-1 2), well class 1...
Klebsiella pneumoniae is an increasingly important hospital pathogen. Classical K. (cKp) and hypervirulent (hvKp) are two distinct evolutionary genetic lines. The recently ongoing evolution of resulted in the generation hybrid hvKP-MDR strains. isolates (n = 70) belonged to 20 sequence types with prevalence ST395 (27.1%), ST23 (18.6%), ST147 (15.7%), ST86 (7.1%), 17 capsular predominance K2 (31.4%), K57 K64 (10.0%), K1 (5.7%) were isolated from patients Moscow neurosurgery ICU 2014-2019....
The increasing antibiotic resistance is a clinical problem worldwide. Numerous Gram-negative bacteria have already become resistant to the most widely used class of antibacterial drugs, β-lactams. One main mechanisms inactivation β-lactam antibiotics by bacterial β-lactamases. Appearance and spread these enzymes represent continuous challenge for treatment infections design new inhibitors. Drug repurposing prospective approach finding targets drugs approved use. We describe here inhibitory...
The spread of multidrug-resistant Gram-negative bacteria, which is associated with the distribution beta-lactamase genes and class 1 2 integrons, a global problem. In this study, in Moscow neurosurgery intensive care unit (neuro-ICU), high prevalence above-stated was found to be intestinal tracheal carriage. Seven-point surveys, included 60 patients neuro-ICU, were conducted weekly period from Oct. Nov. 2019. A total 293 clinical samples analyzed, including 146 rectal 147 swabs; 344 bacteria...
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Klebsiella pneumoniae causes both nosocomial and community-associated infections. Among the hypervirulent K. (hvKP) isolates, K1 is most common capsular serotype. Here, we report draft genome sequences of 3 K1-type (sequence type 23) strains isolated from healthy microbiology laboratory staff in Russia.