A5068955186- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Analysis
- Bioactive natural compounds
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Hydrolysis and Bioactive Peptides
- Electrochemical sensors and biosensors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Pharmacological Effects of Natural Compounds
- Gastric Cancer Management and Outcomes
- Tea Polyphenols and Effects
- Neuroscience and Neuropharmacology Research
- Biomarkers in Disease Mechanisms
- Ginseng Biological Effects and Applications
- Monoclonal and Polyclonal Antibodies Research
- Microbial Metabolism and Applications
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- Glycosylation and Glycoproteins Research
- Inflammasome and immune disorders
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Colorectal Cancer Surgical Treatments
Heilongjiang University of Chinese Medicine
2015-2021
Harbin University of Commerce
2015-2019
Yangtze University
2017
University of South China
2016
Ministry of Education of the People's Republic of China
2016
Hunan Cancer Hospital
2015
Central South University
2015
Shanghai Cancer Institute
2011
State Key Laboratory of Oncogene and Related Genes
2011
MicroRNA-9 (miR-9) plays important roles in nervous system diseases such as glioblastoma and neurodegenerative disorders. However, how miR-9 contributes to dementia requires further study. In this study, we evaluated the role of molecular mechanisms underlying its effects.A rat model was created by occlusion bilateral common carotid artery (2VO) for 8 weeks. Learning memory were assessed using Morris Water Maze (MWM). MicroRNA expression profiling performed according a protocol provided LC...
A role for the NLRP3 inflammasome has been reported in various diseases, such as diabetes mellitus, atherosclerosis (AS), nephropathy, rheumatism, and others, although limited information is available concerning of inflammasome, interleukin-1β (IL-1β) interleukin-18 (IL-18) patients with type 2 mellitus (T2DM) carotid (CAS). Therefore, this cross-sectional study investigated these inflammatory components T2DM complicated (T2DM + CAS).A total 107 inpatients or outpatients were...
Diabetes accelerates memory dysfunction in a continuous, slowly pathological process. Studies suggest that the time course of certain biomarkers can characterize disease to provide information for early intervention. Thus, there is an urgent need validated cognitive impairment induced by DM. We aimed detect changes cerebrospinal fluid such as amyloid β42, phosphorylated tau protein, interleukin 6, and acetylcholine diabetic rats over time, analyse relationship between diabetes...
A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl 4-hydroxybenzyl as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) gastric cell lines (SGC-7901) in vitro evaluated by standard methyl thiazole tetrazolium (MTT) method. The result biological test shows that some possess stronger anti-cancer than 5-FU. Compound 5c strongest activity against IC50 value 50.19 ± 1.02...
Panax quinquefolius (PQ) and Acorus gramineus (AG) are drug target pairs in traditional Chinese medicine (TCM), which used to treat age-related diseases. In the present study, we simultaneously determined contents of four main bioactive ginsenosides (Rb1, Rb2, Rd, Re) rat plasma using an ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. Plasma specimens were purified by solid-phase extraction procedure, separation was performed on Waters ACQUITY UPLC...
The objective of this study was to examine the safety multiple repeated percutaneous punctures cisterna magna for collecting cerebrospinal fluid (CSF) and preliminarily determine optimal time interval volume at each collection. Sixty Wistar rats were randomly assigned six groups: 10 d-0 μL, d-100 μL (100 CSF collected an days), d-150 15 μL. by puncture four time-points. Simultaneously, locomotor activity, pressure, acetylcholine levels in monitored. Compared with group, escape latency Morris...