A5075655220- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Musculoskeletal pain and rehabilitation
- Hereditary Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Health, Medicine and Society
- Prosthetics and Rehabilitation Robotics
- Parkinson's Disease and Spinal Disorders
- Inflammatory Myopathies and Dermatomyositis
- Stroke Rehabilitation and Recovery
- Pain Management and Treatment
- Viral Infections and Immunology Research
- Peripheral Nerve Disorders
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Systemic Sclerosis and Related Diseases
- Amyotrophic Lateral Sclerosis Research
- Total Knee Arthroplasty Outcomes
- Telomeres, Telomerase, and Senescence
Centre Hospitalier Universitaire de Lille
2014-2025
Unité de Recherche Pluridisciplinaire Sport, Santé, Société
2015-2023
Université de Lille
2009-2022
Institut Régional de Médecine Physique et de Réadaptation
2006-2022
Université Lille Nord de France
2009-2020
Centre Oscar Lambret
2013-2019
Laboratoire Motricité Humaine Éducation Sport Santé
2019
Sorbonne Université
2007-2017
Institut de Myologie
2007-2017
Pitié-Salpêtrière Hospital
2017
Background: An accurate estimation of the risk life-threatening (LT) ventricular tachyarrhythmia (VTA) in patients with LMNA mutations is crucial to select candidates for implantable cardioverter-defibrillator implantation. Methods: We included 839 adult mutations, including 660 from a French nationwide registry development sample, and 179 other countries, referred 5 tertiary centers cardiomyopathies, validation sample. LTVTA was defined as (1) sudden cardiac death or (2) cardioverter...
Background Myotonic Dystrophy type 1 (DM1) is one of the most heterogeneous hereditary disease in terms age onset, clinical manifestations, and severity, challenging both medical management trials. The CTG expansion size main factor determining onset although no can finely predict phenotype prognosis. Differences between males females have not been specifically reported. Our aim to study gender impact on DM1 severity. Methods We first performed cross-sectional analysis multiorgan parameters...
Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited neuropathy caused by an autosomal dominant duplication of gene encoding for the structural myelin protein PMP22, which induces abnormal Schwann cell differentiation and dysmyelination, eventually leading to axonal suffering then loss muscle wasting. We favour idea that diseases can be more efficiently treated when targeting multiple disease-relevant pathways. In CMT1A patients, we therefore tested potential PXT3003,...
Introduction Upper limb evaluation of patients with Duchenne Muscular Dystrophy is crucially important to evaluations efficacy new treatments in non-ambulant patients. In who have lost ambulation, there are few validated and informative outcome measures. addition, longitudinal data demonstrating sensitivity clinical evolution measures over short-term periods lacking. Patients Methods We report here the results a one-year multicenter study using specifically designed tools assess grip, pinch...
Objective To compare a physical therapy program to usual care of systemic sclerosis (SSc) patients on disability. Methods A 12‐month followup, parallel‐group randomized controlled trial involving modified Zelen design was conducted in 4 tertiary‐care hospitals. Patients were enrolled if they had disability rating ≥0.5 the Health Assessment Questionnaire index (HAQ DI) or symptoms decreased mouth opening limited range motion at least 1 joint. The experimental intervention (n = 112, which 110...
<h3>Background</h3> Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought assess the drug9s impact on axial symptoms advanced Parkinson9s disease (PD). <h3>Methods</h3> We performed a 90-day, randomised, double-blind, study with two parallel arms: 20 mg/day versus placebo (ClinicalTrials.gov:NCT01108029). The main inclusion criterion was presence of severe gait disorder an abnormal,...
Assessment of the upper limb strength in non-ambulant neuromuscular patients remains challenging. Although potential outcome measures have been reported, longitudinal data demonstrating sensitivity to clinical evolution spinal muscular atrophy are critically lacking. Our study recruited 23 patients, 16 (males/females = 6/10; median age 15.4 years with a range from 10.7 31.1 years) type II and 7 2/5; 19.9 8.3 29.9 III. The Brooke functional score was on 3 2 6. average total vital capacity...
To estimate the effect of prophylactic angiotensin-converting enzyme inhibitors (ACEi) on survival in Duchenne muscular dystrophy (DMD).We analysed data from French multicentre DMD Heart Registry (ClinicalTrials.gov: NCT03443115). We estimated association between prescription ACEi and event-free 668 patients aged 8 to 13 years, with normal left ventricular function, using (i) a Cox model intervention as time-dependent covariate, (ii) propensity-based analysis comparing treatment vs. no...
The life expectancy of patients with Duchenne muscular dystrophy (DMD) has increased. A cross-sectional study DMD showed that 54 % 13-year-old are obese and 18-year-old underweight. We aimed to describe the natural evolution weight status in DMD. This retrospective multi-centre audit collected body-weight measurements for seventy born before 1992. body-weight:age ratio (W:A) was used evaluate reference Griffiths Edwards chart. At age 13 years, 73 were 4 maximal follow-up (age 15–26 mean 18·3...
<h3>Objective</h3> Mutations in one of the 3 genes encoding collagen VI (COLVI) are responsible for a group heterogeneous phenotypes which Bethlem myopathy (BM) represents milder end spectrum. Genotype-phenotype correlations and long-term follow-up description BM remain scarce. <h3>Methods</h3> We retrospectively evaluated clinical evolution, genotype-phenotype 35 genetically identified patients (23 index cases). <h3>Results</h3> Nineteen showed typical picture with contractures, proximal...
The aim of this prospective study was to investigate changes in muscle activity during gait children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) 16 DMD and pathological were compared those 15 control children. the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) gastrocnemius soleus (GAS) muscles recorded analysed quantitatively qualitatively. overall significantly different from that group. Percentage...
Background Subtelomeres are variable regions between telomeres and chromosomal-specific regions. One of the most studied pathologies linked to subtelomeric imbalance is facioscapulohumeral dystrophy (FSHD). In cases, this disease involves shortening an array D4Z4 macrosatellite elements at 4q35 locus. The also segregates with a specific A-type haplotype containing degenerated polyadenylation signal distal last repeat followed by repetitive β-satellite elements. This classification applies...
<title>Abstract</title> <bold>Purpose</bold> Chronic lower back pain is a multifactorial health problem that can involve the intervertebral discs. The objective of present clinical trial was to describe effect trunk exoskeleton on level experienced during standardized activity track. <bold>Materials and Methods</bold> Thirty-one patients with chronic agreed wear device daily perform track as part hospital-based multidisciplinary rehabilitation programme. participants were randomized use day...
The objective of this study was to evaluate pain frequency, severity, location, treatment, and relief in a population adult patients with neuromuscular disorders (NMD).The authors used self-completion mail questionnaire from the Physical Medicine Clinic at Lille University Medical Center (northern France). Two hundred eighty-one adults confirmed diagnosis hereditary disease were mailed questionnaire, which returned by 125 subjects (response rate = 45%). main outcome measures mean motor...