A5015764648- Spine and Intervertebral Disc Pathology
- TGF-β signaling in diseases
- Plant Toxicity and Pharmacological Properties
- Pain Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
Sun Yat-sen University
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Abstract The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, single‐cell transcriptomic atlas mapping early IVD formation is still lacking. Here, authors generate spatiotemporal and single cell‐based human at embryonic stage comparative mouse transcript landscape. They identify two novel notochord (NC)/nucleus pulposus (NP) clusters, SRY‐box transcription...
Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP). However, effective therapeutic drugs for IDD remain to be further explored. Inflammatory cytokines play a pivotal role in onset and progression IDD. Dihydroartemisinin (DHA) has been well reported have powerful anti-inflammatory effects, but whether DHA could ameliorate development remained unclear. In this study, effects on extracellular matrix (ECM) metabolism cellular senescence were firstly investigated...