A5100385042- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Adrenal Hormones and Disorders
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Autoimmune and Inflammatory Disorders Research
- Neurogenetic and Muscular Disorders Research
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- Psoriasis: Treatment and Pathogenesis
- HER2/EGFR in Cancer Research
MRC Weatherall Institute of Molecular Medicine
2024
University of Oxford
2024
Medical Research Council
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Peking Union Medical College Hospital
2023
Institute of Hematology & Blood Diseases Hospital
2015-2022
Southwest Medical University
2022
George Washington University
2021
Army Medical University
2019
Sylvester Comprehensive Cancer Center
2018
// Juan Du 1,* , Shuyan Liu Jie He 1 Xi Ying Qu Wenqing Yan Jianling Fan Rong Li Hao Weijun Fu Chunyang Zhang Jing Yang 2 and Jian Hou Department of Hematology, The Myeloma Lymphoma Center, Changzheng Hospital, Second Military Medical University, Shanghai, China Lymphoma/Myeloma, Division Cancer Medicine Center for Immunology Research, University Texas, MD Anderson Houston, USA * These authors have contributed equally to this work Correspondence to: Hou, email: Keywords : multiple myeloma;...
TET2 is a methylcytosine dioxygenase that regulates cytosine hydroxymethylation. Although there are extensive data implicating pivotal role of in hematopoietic stem/progenitor cells (HSPCs), the importance bone marrow mesenchymal stromal (BMSCs) remains unknown. In this study, we show loss BMSCs increases cell proliferation and self-renewal enhances osteoblast differentiation potential BMSCs, which may turn alter their behavior supporting HSPC differentiation. addition, Tet2 alters promoting...
Somatic or de novo mutations of Additional sex combs-like 1 (ASXL1) frequently occur in patients with myeloid malignancies Bohring-Opitz syndrome, respectively. We have reported that global loss Asxl1 leads to the development and impairs bone marrow stromal cell (BMSC) fates mice. However, impact deletion BM niche on hematopoiesis remains unclear. Here, we showed BMSCs derived from chronic myelomonocytic leukemia had reduced expression ASXL1, which impaired maintaining cord blood CD34+...
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present early-stage disease, but substantial proportion progress to myelofibrosis or secondary leukemia, advanced poor prognosis high symptom burden. Currently, it remains difficult predict progression, therapies that reliably prevent reverse fibrosis lacking. A major bottleneck the discovery disease-modifying has been an incomplete understanding interplay...
Balance between the hematopoietic stem cell (HSC) duality to either possess self-renewal capacity or differentiate into multipotency progenitors (MPPs) is crucial for maintaining homeostasis of stem/progenitor (HSPC) compartment. To retain HSC activity, KIT, a receptor tyrosine kinase, in HSCs activated by its cognate ligand KITLG originating from niche cells. Here, we show that AT-rich interaction domain 4B (ARID4B) interferes with KITLG/KIT signaling, consequently allowing differentiation....
Multiple myeloma (MM) is the second most common hematologic malignancy. There are no standard therapeutic guidelines for extramedullary invasion (EM). We performed a retrospective integrated transcriptomic analysis based on GEO, TCGA, and Oncomine datasets with total of over 2,500 cases enrolled. GSVA was GSE24080. The external validation cohorts include GSE9782, GSE2658, MMRF-COMPASS, Oncomine. data MGUS to relapsed MM were acquired from GSE6477, GSE5900, EM GSE39683 GSE66291. Single-cell...
Bone marrow stromal cells (BMSCs) represent an important cellular component of the bone microenvironment, which play role in supporting and regulating proliferation differentiation hematopoietic stem/progenitor (HSPCs). We have previously reported that ability BMSCs derived from CMML patients (CMML-BMSCs) expansion cord blood (CB) CD34 + was significantly reduced compared to healthy donors (HD-BMSCs). In addition, CMML-BMSCs led a skewed CB favoring myeloid lineage with HD-BMSCs. To assess...
Exposure to ionizing radiation combined with traumatic tissue injury is an important life-threatening condition found in the civilian populations after nuclear and radiological events. The significance feature of (RCI) severe effect, which makes more complicated. At present, there are limited measures available treat RCI. Here we show that a chimeric protein dTMP-GH, fusing human growth hormone (hGH) tandem dimer thrombopoietin mimetic peptide (dTMP), could be effective therapy agent for RCI...
<h3>Background</h3> Lupus nephritis (LN) is one of the most common organ-specific injury systemic lupus erythematosus (SLE) and has great influence on patients' prognosis. Some research showed that interleukin (IL) -22 was enriched in kidney tissue MRL/lpr mice, it related to lesions. The proportion Th22 cells IL-22 periphery blood mononucleated cell (PBMC) LN patients were found increased, suggesting IL-22/Th22 may be participated development LN. About seventy-five percent SLE significantly...
Abstract Background Multiple myeloma (MM) remains an incurable hematologic malignancy mainly due to its cytogenetic abnormalities. It is important establish permanent malignant MM cell lines as effective tools develop more therapies. Results We established and characterized a new multiple line CZ2 from the pleural effusion of 70-year-old man. Using nephelometry flow cytometry, cells with typical plasma morphology but not classical phenotype were found be non-immunoglobulin-secretary cells....