A5007890335- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Ionic liquids properties and applications
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Multicomponent Synthesis of Heterocycles
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Synthesis of Organic Compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Coordination Chemistry and Organometallics
- Synthesis and pharmacology of benzodiazepine derivatives
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Catalytic Cross-Coupling Reactions
- Vanadium and Halogenation Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biosensors and Analytical Detection
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- Molecular Biology Techniques and Applications
Albany Molecular Research (United States)
2023-2025
Ollscoil na Gaillimhe – University of Galway
2010-2019
University College Dublin
2010-2011
Humboldt-Universität zu Berlin
2004-2008
National Chemical Laboratory
2001-2003
Abstract Fluorescent base analogues in DNA are versatile probes of nucleic acid–nucleic acid and acid–protein interactions. New peptide (PNA) based described which the intercalator dye thiazole orange (TO) serves as a surrogate. The investigation six TO derivatives revealed that linker length conjugation site decided whether surrogate conveys sequence‐selective binding fluorescence is increased or decreased upon single‐mismatched hybridization. One derivative conferred universal PNA–DNA...
Palladium catalyzed Suzuki cross-coupling reactions of halobenzenes including chlorobenzenes with phenylboronic acid have been achieved at ambient temperature (30 degrees C) in the absence a phosphine ligand using ionic liquid 1,3-di-n-butylimidazolium tetrafluoroborate [bbim][BF4] methanol as co-solvent under ultrasonic irradiation.
The condensation reaction of 4-oxo-(4H)-1-benzopyran-3-carbaldehydes and aromatic aldehydes with 3-methyl-1-phenylpyrazolin-5-(4H)-one were carried out in an ionic liquid, ethylammonium nitrate, at room temperature shorter times higher yields 78–92 70–75%, respectively, than found using conventional procedures.
Double-stranded DNA offers multiple binding sites to stains. Measurements of noncovalently bound dye-nucleic acid complexes are, necessarily, measurements an ensemble chromophores. Thus, it is difficult assign fluorescence properties base-pair-specific modes cyanine dyes or, vice versa, obtain information about the local environment cyanines in nucleic acids by using optical spectroscopy. The feasibility stain and simultaneously probe perturbations spectroscopy would be a valuable asset...
Abstract 2,3‐biindole (or 2,3‐bisindole) is an important structural feature found in many biologically active synthetic and natural products. Though excellent methods have been reported to achieve selective 2,3′homodimerization of indole produce compounds, most them need strong co‐oxidants other additives enable the reactions. In recent times, mechanochemistry picking up as a promising sustainable, environmentally‐benign tool modern organic chemistry. Because, not only presents fair deal...
Abstract Fluorescent nucleobase surrogates provide nucleic acids with interesting properties. We have recently introduced thiazole orange as base surrogate into PNA and found that the so‐called FIT ( F orced I ntercalation of T hiazole orange) probes signal hybridization by enhancements fluorescence. Common approaches modifying nucleobases or introducing draw upon usage monomer building blocks been synthesized in solution phase. The need to prefabricate a base‐modified block can hold up...
A simple, efficient and environment ecofriendly route has been developed for the synthesis of ylidenenitriles 4-oxo-(4H)-1-benzopyran-3-carbaldehyde by condensation with active methylene compounds viz. malononitrile, cyanoacetic acid cyanoacetamide in distilled water without catalyst at 90 °C 1–2 h quantitative yields higher selectivity.
Abstract Macrocycles containing embedded carbohydrates are found in nature. Tricholorin A and G, woodrosin, sophorolipid lactone, cycloviracin B1, glucolipsin ipomoeassins A–F natural products with interesting biological properties. They have inspired synthesis of non‐natural macrocyclic structures which contain carbohydrates. Glycophanes (hybrids cyclophanes) were prepared show potential host‐guest chemistry been applied as rigid scaffolds for the bivalent inhibitors lectin binding to...
A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led the identification of inducer apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.
Chromone-2-carboxylate scaffold is growing as an important pharmacophore in medicinal chemistry with diverse biological properties. We have developed a facile one-pot transformation of 2-fluoroacetophenone directly to chromone-2-carboxylate single step via tandem C–C and C–O bond formation. The majority the previously reported synthetic protocols primarily used only one procedure which follows two-step strategy that needs start "2-hydroxyacetophenone". Our methodology not serves alternative...
The fluorescence of thiazole orange as artificial base in PNA was investigated a nearest neighbour analysis; library-to-library hybridisation allowed the identification probe sequences suitable for homogeneous DNA detection.
Abstract Aromatic and heteroaromatic groups that are forced to intercalate at specific positions in DNA versatile probes of DNA–DNA DNA–protein recognition. Fluorescent nucleobases value since they able report on localized alterations duplex structure. However, the fluorescence vast majority base surrogates becomes quenched upon intercalation DNA. Peptide nucleic acid (PNA)-based presented which intercalator dye thiazole orange (TO) serves as a fluorescent surrogate. In these probes,...
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