A5074185149- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- ATP Synthase and ATPases Research
- Acute Myeloid Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Genetic Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Simulation-Based Education in Healthcare
- Innovations in Medical Education
- Photosynthetic Processes and Mechanisms
- COVID-19 and healthcare impacts
- Hemoglobinopathies and Related Disorders
University of Bristol
2021-2024
Mitochondrial supercomplexes form around a conserved core of monomeric complex I and dimeric III; wherein subunit the former, NDUFA11, is conspicuously situated at interface. We identified nduf-11 (B0491.5) as encoding Caenorhabditis elegans homologue NDUFA11. Animals homozygous for CRISPR-Cas9-generated knockout allele arrested second larval (L2) development stage. Reducing (but not eliminating) expression using RNAi allowed to adulthood, enabling characterisation consequences:...
There is wide interindividual variation in the efficacy of CD34
ABSTRACT Background There is a large inter-individual variation in CD34+ cell yield after G-CSF mobilisation and collection from peripheral blood healthy allogenic haematopoietic stem donors. Donor characteristics including gender age, baseline pre-collection results, factors have been associated with concentration the and/or collection. Since literature reporting these associations heterogeneous, we here clarify determinants of through scoping review. Materials Methods MEDLINE, Embase,...
ABSTRACT Mitochondrial super-complexes form around a conserved core of monomeric complex I and dimeric III; wherein subunit NDUFA11, the former, is conspicuously situated at interface. We identified B0491 . 5 ( NDUF-11 ) as C. elegans homologue, which animals homozygous for CRISPR-Cas9 generated knockout allele arrested L2 development stage. Reducing expression by RNAi allowed to adult stage, enabling characterisation consequences: destabilisation its super-complexes, perturbation...
ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Amber Knapp-Wilson co-first author on ‘Maintenance complex I and its supercomplexes by NDUF-11 essential for mitochondrial structure, function health’, JCS. conducted research described this article while PhD student labs Professor Ian Collinson Patricia Kuwabara at University Bristol, UK. She...