A5100386580- Wound Healing and Treatments
- Nephrotoxicity and Medicinal Plants
- Electrospun Nanofibers in Biomedical Applications
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Fuel Cells and Related Materials
- Retinoids in leukemia and cellular processes
- Renal Diseases and Glomerulopathies
- Electrocatalysts for Energy Conversion
- Drug-Induced Hepatotoxicity and Protection
- Advancements in Transdermal Drug Delivery
- Acute Kidney Injury Research
- Berberine and alkaloids research
- Phytochemistry and biological activities of Ficus species
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- interferon and immune responses
- MicroRNA in disease regulation
- Chemotherapy-related skin toxicity
- Natural Compounds in Disease Treatment
- Nigella sativa pharmacological applications
- Stroke Rehabilitation and Recovery
- Ginseng Biological Effects and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Hydrogels: synthesis, properties, applications
Nanjing University of Chinese Medicine
2010-2025
Hebei University of Engineering
2024
Chongqing Medical University
2022
Children's Hospital of Chongqing Medical University
2022
East China University of Science and Technology
2017-2021
Zhujiang Hospital
2020
Southern Medical University
2020
Abstract Acute promyelocytic leukemia (APL) is a blood system disease caused by the accumulation of large number immature cells in bone marrow. Although introduction all- trans retinoic acid (ATRA) and arsenic has reached high level complete remission rate 5-year disease-free survival rate, occurrence various adverse reactions still severely affects quality life patients. As natural product, honokiol (HNK) advantages low toxicity efficiency, it potential drug for treatment cancer. Since...
Immunoregulation is one of the important factors in wound healing. Currently, dressings with immunoregulation necessary to overcome complicated interventions, high-cost treatments and uncontrolled release behaviors. In this study, a novel Cu Zn loaded nanofiber dressing (FM-Cu-Zn) controllable without external intervention was prepared by electrospinning. The composed ZnCl2, CuS nano particles, poly-3-hydroxybutyrate-co-4-hydroxybutyrate (P34HB). Where Zn2+ "promoter" immunotherapeutic...
Abstract Berberine (BBR) exerts specific therapeutic effects on various diseases such as diabetes, obesity, and other inflammation-associated diseases. However, the low oral bioavailability (below 1%) of berberine due to its poor solubility membrane permeability limits clinical use. In this paper, we have prepared a 1:1 co-crystal berberine-ibuprofen (BJ) using drug salt metathesis technology. Pharmacokinetic studies demonstrate 3-fold increase in vivo BJ compared that BBR, is more effective...
Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by leukemia-retinoic acid receptor A (PML-RARA) fusion gene. The therapeutic drugs currently used to treat APL have adverse effects. 20(S)-ginsenoside Rh2 (GRh2) an anticancer medicine with high effectiveness and low toxicity. However, the underlying mechanisms of GRh2-induced PML-RARA degradation apoptosis in human cell line (NB4 cells) remain unclear.Apoptosis-related indicators expression were determined investigate...
Background and objective: Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration iodinated contrast media (CM) for diagnostic interventional cardiovascular procedures associated with substantial morbidity mortality. While preventative measures can mitigate risk CI-AKI, there remains need novel effective therapeutic approaches. The pathogenesis CI-AKI complex not completely understood. CM-induced renal tubular cell apoptosis caused by activation...
Paclitaxel-induced peripheral neuropathy (PIPN) is one of the common adverse effects during paclitaxel (PTX) treatment cancer. In this study, we investigated neuroprotective and mechanisms thymoquinone (TQ) in PIPN model. Through pain behavioral assays histological assessment, demonstrated that TQ significantly alleviated nociceptive behavior, modulated pathological changes nerves, decreased expression inflammatory factors TNF-α, IL-1β, IL-6 induced by mice. addition, reversed reduced...
The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal healing. There still remain great challenges in developing safe and effective dressings wide-spectrum antibacterial functions. Alginate hydrogel a common dressing for treatment. Copper one trace elements human body inherent activity. Traditional methods preparing structure-controlled copper-alginate matrix are difficult...
Oxaliplatin (OXA) is a key platinum-based chemotherapeutic agent for treatment of metastatic colorectal cancer, but the side effects acute and chronic neuropathies limit its clinical application. Duloxetine has been found to have potential prevent OXA-induced peripheral neuropathy in several studies, underlying mechanisms remain unclear. The purpose this study was evaluate duloxetine on find mechanisms. neuropathic pain mice model used explore role by measuring change thermal withdrawal...
Abstract The authors have requested that this preprint be removed from Research Square.
Background Some studies have shown that hypothermia is a neuroprotective factor for cerebral ischemic injury. The inflammation reaction plays very important role in the pathomechanisms of neuron degeneration induced by ischemia. It not known whether there relationship between cold irritation and reaction. Goals To explore effect on peripheral white blood cells intercellular adhesion molecule-1 (ICAM-1), interleukin-1 (IL-1) β expression brain tissue rat with Methods Model rats were put into...
Aim: This study aimed to explore the genetic risk factors and validate variants of abnormal uterine bleeding after copper intrauterine device insertion. Methods: Whole-exome sequencing was performed several were validated by Sequenom MassARRAY. Results: Eight showed potential clinical damage according American College Medical Genetics Genomics criteria. By combined analysis screening validation, NFASCRS2802808C>G p.Ile971Met (Pallele = 0.009 Pgenotype 0.027) PIGRRS2275531C>T p.Gly365Ser...