A5073149154- Hearing, Cochlea, Tinnitus, Genetics
- Motor Control and Adaptation
- Gaze Tracking and Assistive Technology
- Signaling Pathways in Disease
- Hand Gesture Recognition Systems
- Visual perception and processing mechanisms
- Freshwater macroinvertebrate diversity and ecology
- Environmental DNA in Biodiversity Studies
- Infectious Diseases and Mycology
- Nerve injury and regeneration
- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Vestibular and auditory disorders
- Neurogenesis and neuroplasticity mechanisms
- Ear Surgery and Otitis Media
- melanin and skin pigmentation
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
University of Toronto
2022-2025
University of Manitoba
2019-2022
The stria vascularis (SV) is an essential component of the inner ear that regulates ionic environment required for hearing. SV degeneration disrupts cochlear homeostasis, leading to irreversible hearing loss, yet a comprehensive understanding SV, and consequently therapeutic availability degeneration, lacking. We developed whole-tissue explant model from neonatal mature mice create platform advancing research. validated our by demonstrating proliferative behavior in vitro mimics vivo. also...
The stria vascularis (SV), part of the blood-labyrinth barrier, is an essential component inner ear that regulates ionic environment required for hearing. SV degeneration disrupts cochlear homeostasis, leading to irreversible hearing loss, yet a comprehensive understanding SV, and consequently therapeutic availability degeneration, lacking. We developed whole-tissue explant model from neonatal adult mice create robust platform research. validated our by demonstrating proliferative behaviour
The pale summer sedge caddisfly, Limnephilus hyalinus Hagen, 1861 (Limnephilidae, the Northern Caddisflies), is widespread in North America. Genome skimming by Illumina sequencing allowed assembly of a complete 15,168 bp circular mitogenome from L. consisting 78.0% AT nucleotides, 22 tRNAs, 13 protein-coding genes, two rRNAs and control region ancestral insect gene order. COX1 features an atypical CGA start codon while ATP8, NAD1, NAD5, NAD6 exhibit incomplete stop codons. mtTERM binding...
Myelin‐associated glycoprotein (MAG) and Nogo inhibit neurite outgrowth by binding to receptors such as NgR1, PirB LRP1, they have also been shown induce phosphorylation of Smad2, a key intermediate in the transforming growth factor β (TGFβ) signalling pathway. In this study, we determined that MAG do not transactivate TGFβ receptor through their canonical or discoidin domain 1, which identified novel for Nogo. Instead, promoted Smad2 stimulating secretion TGFβ. Proteomic analysis neuronal...
Previous research in our lab has revealed a strong visual bias toward the eventual index finger contact location when grasping stationary or horizontally moving targets. However, unique properties of thumb may have an increased role vertically Using their and thumb, right-handed individuals reached for grasped 2-D rectangular targets upward downward on oriented computer screen. It was expected that fixations would be directed targets, to In trials involving initial were positioned well above...