A5081079219- Economic and Financial Impacts of Cancer
- Antibiotic Resistance in Bacteria
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Genomics and Phylogenetic Studies
- Heart Failure Treatment and Management
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Pain Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Cancer Genomics and Diagnostics
- Cardiac Arrest and Resuscitation
- Biosimilars and Bioanalytical Methods
- Child Nutrition and Water Access
- Pharmaceutical Economics and Policy
- Respiratory Support and Mechanisms
- Treatment of Major Depression
- Bacterial Identification and Susceptibility Testing
- Nutritional Studies and Diet
- Food Security and Health in Diverse Populations
- Botulinum Toxin and Related Neurological Disorders
Optum (United States)
2016-2025
Central Institute of Mental Health
2022-2023
Heidelberg University
2022-2023
University Hospital Heidelberg
2022-2023
Robert Koch Institute
2015-2023
Johannes Gutenberg University Mainz
2022
George Mason University
2022
Brandeis University
2022
Humboldt-Universität zu Berlin
1973-2020
Results for Development Institute
2019-2020
The purpose of this study was to validate autism spectrum disorder cases identified through claims-based case identification algorithms against a clinical review medical charts. Charts were reviewed for 432 children who fell into one the three following groups: (a) more than or equal two claims with an diagnosis code (n = 182), (b) claim 190), and (c) those had no but other developmental neurological conditions 60). algorithm-based diagnoses compared documented disorders in algorithm...
By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014.We selected representative subset 107 clinical isolates possessing the four most prevalent carbapenemase types (KPC-2, KPC-3, OXA-48, NDM-1). Isolates were processed via illumina NGS. Data analysed different SNP-based mapping de-novo assembly approaches. Relevant information was extracted NGS (antibiotic...
Myelosuppressive chemotherapy can lead to dose-limiting febrile neutropenia. Prophylactic use of recombinant human G-CSF such as daily filgrastim and once-per-cycle pegfilgrastim may reduce the incidence This comparative study examined effect versus on risk hospitalization.This retrospective United States claims analysis utilized 2004-2009 data for filgrastim- pegfilgrastim-treated patients receiving non-Hodgkin's lymphoma (NHL) or breast, lung, ovarian, colorectal cancers. Cycles in which...
Infant-specific pertussis data, especially among neonates, are limited and variable. This study (NCT01890850) provides overall age-specific incidence associated health care utilization costs commercially insured infants in the US.Nearly 1.2 million born from 2005 to 2010 with commercial plan coverage were followed during their first 12 months of life. Pertussis cases identified medical claims (International Classification Diseases, 9th revision, Clinical Modification code: 033.0, 033.9,...
Abstract We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae subsequent Miseq sequencing. Purification was based on matrix binding (silica or anion exchange resin) differential precipitation (salting out), respectively. The choice kit had little effect sequencing quality and coverage across drastically different replicons, except an apparent depletion small plasmids (<5 kb) during precipitation-based extractions. Sequencing...
Extended-spectrum β-lactamase (ESBL) producing Klebsiella pneumoniae pose an important threat of infection with increased morbidity and mortality, especially for immunocompromised patients. Here we use the rise multi-drug resistant K. in a German neurorehabilitation centre from April 2015 to 2016 dissect benefit whole genome sequencing (WGS) outbreak analyses. In total, 53 isolates were obtained 52 patients examined using WGS. Two independent analysis strategies (reference-based -free)...
Background Lowering low‐density lipoprotein cholesterol with statins reduces risk of cardiovascular events. We examined patterns and predictors filled prescriptions for lipid‐lowering therapy (LLT) in subgroups patients atherosclerotic disease ( ASCVD ) and/or diabetes mellitus DM ). Hypothesis Statin treatment remains underutilized across high CV patients. Methods Patients the Optum Research Database these criteria were included: age ≥20 years, 2 years continuous enrollment, ....
The forced swim test (FST) is a traditional assay, which has been used for more than 40 years to assess antidepressant effects of novel drug candidates. In recent years, debate about the focused on assumption that FST highly aversive and burdening animals because earlier anthropomorphic interpretation designation as "behavioral despair test". Directive 2010/63/EU German Animal Welfare law require prospective severity classification planned experimental procedures. Still, an objective...
THIS study tested the hypothesis that halothane anesthesia would cause decreased acetylcholine (ACh) release within medial pontine reticular formation (mPRF). ACh was collected by microdialysis and measured high pressure liquid chromatography during wakefulness halothane-induced anesthesia. The electroen-cephalogram (EEG) showed spindles were a reliable indicator of anesthetic depth. There statistically significant disease in compared with wakefulness. Spindles always disappeared noxious...
Objective: Prostate cancer is a leading cause of death in men the US. Castration-resistant prostate (CRPC) an advanced form disease and has poor prognosis limited treatment options. The objective this study was to identify patients with CRPC from medical claims database, determine cancer-related economic burden healthcare utilization these patients.Methods: This retrospective using enrollment information large US database linkable laboratory data. Male aged 40 or older who were diagnosed...
There are limited data examining the real-world use of gabapentin and pregabalin for treatment post-herpetic neuralgia (PHN). This study examines dosing patterns, therapy outcomes, healthcare utilization costs patients with PHN who initiate or pregabalin. was a retrospective administrative claims analysis from July 2005 to February 2010. Patients initiating (index therapy) January 2006 2009 were identified observed 12 months after index initiation. Outcomes mean daily dosages therapy,...
Primary care physicians often do not use spirometry to confirm the diagnosis of chronic obstructive pulmonary disease. This project was designed see how well physicians' impressions about their patients' disease severity correlate with airflow obstruction measured by and assess whether results subsequently changed opinions treatment.We performed a multicenter, cross-sectional, observational study conducted in 83 primary clinics from across United States. A total 899 patients clinical...
BACKGROUND: Administrative claims contain detailed medication, diagnosis, and procedure data, but the lack of clinical outcomes for rheumatoid arthritis (RA) historically has limited their use in comparative effectiveness research. A claims-based algorithm was developed validated to estimate RA from data adherence, dosing, treatment modifications. OBJECTIVE: To implement a U.S. managed care database biologic cost per effectively treated patient. METHODS: The cohort included patients with...
To examine treatment patterns, effectiveness, and costs for 1 year after patients with rheumatoid arthritis switched from a tumor necrosis factor inhibitor (TNFi) (adalimumab, certolizumab pegol, etanercept, golimumab, or infliximab), either cycling to another TNFi ("TNFi cyclers") switching new mechanism of action (abatacept, tocilizumab, tofacitinib) ("new MOA switchers").This retrospective cohort study used administrative claims data national insurer. Treatment persistence (without again,...
This study summarizes the experiences of patients, who have multiple comorbidities, with 15 mono-treated antidepressants.This is a retrospective, observational, matched case control study. The cohort was organized using claims data available through OptumLabs for depressed patients treated antidepressants between January 1, 2001 and December 31, 2018. included from all states within United States America. analysis focused on 3,678,082 major depression had 10,221,145 antidepressant...
One possible transmission route for nosocomial pathogens is contaminated medical devices. Formation of biofilms can exacerbate the problem. We report on a carbapenemase-producing Klebsiella pneumoniae that had caused an outbreak linked to duodenoscopes. To determine whether increased tolerance disinfectants may have contributed outbreak, we investigated susceptibility strain commonly used duodenoscope reprocessing. Disinfection efficacy was tested planktonic bacteria and biofilm.Disinfectant...
Abstract Background Pharmacogenomic (PGx) testing can help improve response and remission rates for patients with major depressive disorder (MDD) at least one treatment failure. To investigate real-world outcomes, we examined 1) significant gene-drug interactions (GDIs) 2) healthcare resource utilization (HRU) in a large US insurance claims dataset. Methods Weighted multigene PGx results adult MDD were linked deidentified data. The test report organized medications as congruent (no known or...
Abstract Background Measuring postural sway and comparing results in a pre-post design or with reference values can increase diagnostic accuracy the quality of certain treatments rehabilitation. The process continuously regulating sustaining stable posture involves intricate sensorimotor control. Methods All 173 participants (78♂, 95♀; 21.9 ± 2.7 years, 172.6 9.8 cm; 70.0 13.3 kg; BMI: 22.7 2.8) were students sport health sciences. Static posturography (open eyes, closed eyes) was performed...
PURPOSE Breast cancer (BC) risk prediction is more accurate when clinical and polygenic factors are combined (combined score [CRS]), but little known about how CRS results affect real-world patient management. METHODS Deidentified medical pharmacy claims data were linked with Tyrer-Cuzick (TC) evaluated for BC Patients divided into subcohorts on the basis of lifetime predicted by TC (“+”: ≥20% risk, “–”: <20%): CRS+ TC+, TC–, CRS– TC–. Claims related to screening mammography (SM) in...
Background: In 2011, the traditional Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPD spirometry-based severity classification system was revised to also include exacerbation history and Assessment Test (CAT) modified Medical Research Council Dyspnea Scale (mMRC) scores. This study examined how patients treated in primary care are reclassified by new GOLD compared system, each system's level of agreement with patient's or physician's assessments. Methods: this US...
Palivizumab has been shown to decrease the incidence of hospitalization due respiratory syncytial virus (RSV) in infants at risk severe RSV disease. We examined association between compliance with palivizumab dosing throughout season and RSV-related clinical practice. Subjects who were born discharged from hospital before received ≥1 dose during their first identified a large US commercial health insurance database 01/01/03 12/31/09. deemed compliant if they ≥5 doses without gaps (>35 days)...