A5051069754- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- dental development and anomalies
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Oral and gingival health research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tumors and Oncological Cases
- Indigenous Health, Education, and Rights
- Head and Neck Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Oral and Craniofacial Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- Dental Radiography and Imaging
- Cultural Competency in Health Care
- Public Health and Environmental Issues
- Soft tissue tumor case studies
- Surface Modification and Superhydrophobicity
- Shoulder Injury and Treatment
- Hemostasis and retained surgical items
- Plant Disease Resistance and Genetics
- BRCA gene mutations in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vascular Malformations and Hemangiomas
- Temporomandibular Joint Disorders
University of Chile
2015-2025
Fundación Chile
2024
Universidade Federal da Bahia
2017-2019
Universidad de Santiago de Chile
2019
Universidade Estadual de Campinas (UNICAMP)
2004
Oral leukoplakia is the most frequent and potentially malignant lesion of oral cavity. Although dysplasia grading remains main factor for risk assessment, challenges persist in determining exact transformation, literature has focused on studying alternative biomarkers. The interaction between dysplastic epithelial cells microenvironment starts early, communication mainly mediated by lymphocytes, inflammatory factors, fibroblasts, extracellular matrix, leading to progression....
Amelogenesis imperfecta (AI) is a group of enamel development disorders that alter the structure and chemical composition tissue. There great variability in clinical presentation; according to Witkop, AI can be categorized into 14 subtypes, which makes its diagnosis extremely complex.This study aimed describe determine frequency radiographic features inheritance patterns found 41 Chilean families diagnosed with diverse types AI.We analyzed records, photographs, pedigrees radiographs 121...
Oral squamous cell carcinoma (OSCC) has a poor prognosis and the treatment employed generates significant physical deformity in patients. In recent years, an increase incidence of cases OSCC been observed adult patients up to 45 years old several genetic underrepresented underserved countries. The young people is very relevant because it shows that does not make exceptions hereditarily must play important role. This fact associated with evident biological basis, large majority these do...
The aim of this study was to determine the relative frequency and distribution reactive hyperplastic lesions (RHL) oral mucosa at Oral Pathology Institute School Dentistry University Chile. This a retrospective 1149 biopsies with histopathological diagnosis RHL, performed between 2000 2011. RHL were classified in 4 groups: fibrous hyperplasia (FH), pyogenic granuloma (PG), peripheral giant-cell (PGCG) ossifying fibroma (POF).the most frequent FH (71. 1%), followed by PG (21.1%), PGCG (5 %)...
Objective. The purpose of this study was to conduct a multidisciplinary analysis specific type tooth enamel disturbance (amelogenesis imperfecta) affecting two Chilean families obtain precise diagnosis and investigate possible underlying mutations. Materials methods. Two non-related affected with amelogenesis imperfecta were evaluated clinical, radiographic histopathological Furthermore, pedigrees both constructed the presence eight mutations in enamelin gene (ENAM) three enamelysin (MMP-20)...
Oral cancer in Chile corresponds approximately to 1.6% of all cases. There are few studies about oral epithelial dysplasia and squamous cell carcinoma the Chilean population.To determine frequency hyperkeratosis, mild, moderate severe dysplasia, situ oropharyngeal mucosa a registry Pathology Reference Institute Faculty Dentistry, Universidad de Chile, ten years period.Review clinical records pathological plates 389 patients, obtained between 1990 2009. Cases were selected according their...
Despite the rapid advancements in genomics and enactment of a new cancer law Chile, implementation genetic counseling continues to face significant challenges because limited resources infrastructure.
The genetic basis of oral epithelial (OED) is unknown, and there no reliable method for evaluating the risk malignant transformation. Somatic mutations are responsible transformation dysplastic mucosa to invasive cancer. In addition, these genomic variations could represent objective markers potential We performed whole-exome sequencing 10 OED samples from Brazilian Chilean patients. Using public repositories, we identified 41 deleterious variants that produce high-impact changes in amino...
Este reporte presenta los aspectos clínicos, microscópicos e inmunohistoquímicos de un caso leucoplasia verrugosa proliferativa (LVP) simulando liquen plano oral (LPO) en una paciente 66 años. También revisamos la literatura reportando casos LVP LPO, donde encontramos mayor prevalencia mujeres que no consumen tabaco ni alcohol, con manifestación inicial áreas liquenoides alrededor 59 años, estableciéndose el diagnóstico promedio 6 años después, mientras transformación maligna ocurrió 8 22...
Teeth develop in the mammalian embryo via a series of interactions between odontogenic epithelium and neural crest-derived ectomesenchyme early jaw primordia.The molecular required to generate tooth are mediated by families signaling molecules, which often act reiteratively both temporal spatial manner.In humans, process odontogenesis lasts approximately 18 years, beginning 6th-8th week uterus ending with formation third molars late adolescence.Each passes through stages that follow same...
This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting pathways and variants genes that are frequently mutated in squamous cell carcinoma (OSCC) other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis exome sequencing. Comparative genomic was performed between high-grade (HGD) low-grade (LGD), focusing on 57 well-known cancer genes, which 10 previously described as most OSCC. HGD had significantly...
Chemoprevention can be a treatment for potentially malignant lesions (PMLs). We aimed to evaluate whether artemisinin (ART) and cisplatin (CSP) are associated with apoptosis immunogenic cell death (ICD) in vitro, using oral leukoplakia (OL) squamous carcinoma (OSCC) lines, these compounds prevent OL progression vivo.
Objective: To identify which genes are associated with the clinical phenotype of amelogenesis Imperfecta (AI) and to elucidate these participate in determination isolated syndromic forms. Methods: In this review, all data on mutations described AI-related were obtained from HGMD® Professional. The relation mutations, inheritance, phenotype, type AI country supplemented information literature. identity codes frequency values dbSNP, ClinVar OMIM databases. percentage specificity (PE) was...
The objective of this research was to evaluate the performance specialists in oral medicine doing diagnosis mucosa lesions through digital images comparing general dental practitioner Chile.
El carcinoma oral de células escamosas es la neoplasia maligna más frecuente en cavidad oral. Sin embargo, los estudios sobre supervivencia general pacientes con cáncer son escasos Chile.
Introduction. Lateral periodontal cysts (LPC) are not frequent and the diagnosis is generally established by means of a routine radiological exploration. The aim this article to report case LPC on edentulous area. Case outline. A 59-year-old man was referred with an extensive radiolucent cystic lesion area anterior maxilla, clinical radiographic residual cyst. histopathologic features exhibited LPC. Conclusion. This third reported in literature, which describes different aspect than proposed...
Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. potentially malignant disorder (OPMD) represents a tissue where more probably to occur in comparison with apparently normal counterpart. Objective purpose this study was determine frequency and histoclinicpa- thology these diseases Chilean population. This descriptive retrospective study. Material Methods: Patients diagnosed DPMO, OSCC verrucous (VC) treated Medicine Clinic University Chile...