A5016194406- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Genital Health and Disease
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Cancer Research and Treatments
- Gastrointestinal disorders and treatments
- Vascular Malformations and Hemangiomas
- Urological Disorders and Treatments
- Cancer-related Molecular Pathways
- Biochemical and Molecular Research
- Evolution and Genetic Dynamics
- Cytomegalovirus and herpesvirus research
- Calcium signaling and nucleotide metabolism
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
Università della Svizzera italiana
2023
Institut de génétique et de biologie moléculaire et cellulaire
2020-2021
Centre National de la Recherche Scientifique
2020
Inserm
2020
Université de Strasbourg
2020
St. Luke's-Roosevelt Hospital Center
2013
Society for Maternal-Fetal Medicine
2013
University of Southern California
2013
Justus-Liebig-Universität Gießen
2003
Columbia University
1992
Abstract Infection with severe acute respiratory syndrome coronavirus 2 associates diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors associated adverse disease 2019 (COVID-19) outcomes. Here we discovered that against specific chemokines were omnipresent post-COVID-19, favorable outcome negatively correlated the development of long COVID at 1 yr post-infection. Chemokine also present in HIV-1...
The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of underlying gene defects, it unclear how mutations in any four known ICF genes cause primary immunodeficiency. Here we demonstrate that loss ZBTB24 B cells from mice ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin class-switch recombination consequently impairs production isotype balance....
Background: Intussusception is the most common cause of abdominal emergency in early childhood. The majority cases are ileocolic type intussusception. Only few reports concerning small bowel intussusception have been reported. Patients and Method: We retrospectively reviewed clinical records imaging findings all patients with diagnosis (comparing intussusception), which were documented by ultrasound period April 1997 to January 2001. routine scans included an evaluation entire abdomen using...
Abstract Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors associated with adverse COVID-19 outcomes. Instead, we discovered that against specific chemokines omnipresent after COVID-19, favorable disease, predictive of lack long COVID symptoms at one year post infection. Anti-chemokine present also in HIV-1 infection autoimmune disorders, but they target different...
This study focused on women who had an abnormal Papanicolaou smear and a subsequent colposcopic examination negative for cervical squamous intraepithelial lesion. Cervical swabs obtained during the initial were analyzed human papillomavirus (HPV) DNA, these results correlated with follow-up examinations. Human DNA was detected by dot-blot hybridization in 31 of 109 (28%) cases. The rate biopsy-proved lesion 17 (55%) HPV-positive group compared 9 78 (11%) HPV-negative group. HPV-DNA detection...
Abstract Efficient humoral responses rely on DNA damage, mutagenesis and error-prone repair. B cell receptor diversification through somatic hypermutation (SHM) class switch recombination (CSR) are initiated by cytidine deamination in mediated activation induced deaminase (AID) 1 the subsequent excision of resulting uracils Uracil glycosylase (UNG) mismatch repair (MMR) proteins 2–4 . Although arising faithfully repaired 2–7 , it is not known how these pathways co-opted to generate mutations...