A5065910935- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Nerve injury and regeneration
- Motor Control and Adaptation
- Stress Responses and Cortisol
- Sports injuries and prevention
- Tendon Structure and Treatment
- Infant Development and Preterm Care
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Tryptophan and brain disorders
- Sepsis Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Muscle activation and electromyography studies
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Child and Adolescent Psychosocial and Emotional Development
- Congenital Diaphragmatic Hernia Studies
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Shoulder Injury and Treatment
London Postgraduate Medical and Dental Education
2023
Epsom and St Helier University Hospitals NHS Trust
2021
King's College London
2015-2020
University of Auckland
2018
St Thomas' Hospital
2015
Kings Health Partners
2015
University of Manchester
2011-2012
Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the increases with cumulative exposure to perinatal factors. Our aim was test this in a large cohort preterm using diffusion weighted magnetic resonance imaging (dMRI).We studied 491 (52% male) without focal destructive brain lesions born < 34 weeks, who underwent structural dMRI specialist Neonatal Imaging Centre. median (range) gestational age...
Preterm birth engenders an increased risk of conditions like cerebral palsy and therefore this time may be crucial for the brain's developing sensori-motor system. However, little is known about how cortical function matures at time, whether development influenced by experience, its role in spontaneous motor behavior. We aimed to systematically characterize spatial temporal maturation functional brain activity across period using MRI a custom-made robotic stimulation device. studied 57...
Measures obtained from diffusion-weighted imaging provide objective indices of white matter development and injury in the developing preterm brain. To date, diffusion tensor (DTI) has been used widely, highlighting differences fractional anisotropy (FA) mean diffusivity (MD) between infants at term healthy controls; altered associated with a number perinatal risk factors; correlations FA values neonatal period subsequent neurodevelopmental outcome. Recent developments, including neurite...
Plantar fasciitis is thought to be a self-limiting condition best treated by conservative measures, but despite this many patients have prolonged duration of symptoms and surgery may indicated. Partial plantar fascial release reported short-term success rate up 80%, anecdotally was not represent our local experience.An audit long-term patient-reported outcomes following open partial fascia performed. A total 30 (33 feet) were identified over 10-year period case notes reviewed. Patients...
Abstract Purpose Diffusion magnetic resonance imaging (dMRI) studies report altered white matter (WM) development in preterm infants. Neurite orientation dispersion and density (NODDI) metrics provide more realistic estimations of neurite architecture vivo compared with standard diffusion tensor (DTI) metrics. This study investigated microstructural maturation WM neonates scanned between 25 45 weeks postmenstrual age (PMA) normal neurodevelopmental outcomes at 2 years using DTI NODDI Methods...
The NICE guideline CG149 has increased the number of well infants receiving antibiotics for suspected early-onset sepsis (EOS). Kaiser Permanente risk calculator (SRC) safely and dramatically reduced investigations EOS in USA. This study evaluates current management against SRC.This is a prospective, multicentre, observational across 13 neonatal units London. Infants were born between June August 2019 at ≥34 weeks gestation commenced on cared postnatal/transitional care wards. Data...