A5082636703- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Histiocytic Disorders and Treatments
- Herpesvirus Infections and Treatments
- Kruppel-like factors research
- Heat shock proteins research
- Cytomegalovirus and herpesvirus research
- Vector-Borne Animal Diseases
- Education, Achievement, and Giftedness
- Cancer-related gene regulation
- Adolescent and Pediatric Healthcare
- Middle East and Rwanda Conflicts
- Mental Health and Patient Involvement
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Polyomavirus and related diseases
- Pain Management and Placebo Effect
- Motivation and Self-Concept in Sports
- Genetic Syndromes and Imprinting
- Socioeconomic Development in MENA
- Islamic Studies and History
- Musculoskeletal pain and rehabilitation
- Interprofessional Education and Collaboration
- Job Satisfaction and Organizational Behavior
Texas Chiropractic College
2020
University of Wisconsin–Madison
2007-2020
Center for Cancer Research
2012
University of Houston
2006
Epstein-Barr virus (EBV) is a human herpesvirus associated with B-cell and epithelial cell malignancies. EBV lytically infects normal differentiated oral cells, where it causes tongue lesion known as hairy leukoplakia (OHL) in immunosuppressed patients. However, the cellular mechanism(s) that enable to establish exclusively lytic infection cells are not currently understood. Here we show transcription factor promote differentiation, KLF4, induces differentiation-dependent by binding...
Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV also tumors is unclear, although the association between malaria Burkitt lymphomas (BLs) may involve excessive replication. A particular variant of viral promoter (Zp) that controls reactivation over-represented, relative its frequency in non-malignant tissue, EBV-positive nasopharyngeal carcinomas AIDS-related lymphomas. To date, no functional differences...
ABSTRACT The Epstein-Barr virus (EBV) latent-to-lytic switch is mediated by the viral proteins BZLF1 (Z), BRLF1 (R), and BRRF1 (Na). Since we previously showed that DNA-damaging agents (including chemotherapy irradiation) can induce EBV lytic reactivation recently demonstrated wild-type p53 contributes to reactivation, investigated role of ATM kinase during reactivation. phosphorylates activates p53, as well numerous other substrates involved in cellular DNA damage response. Using an...
// Andrea Bilger 1 , Julie Plowshay 2, 6 Shidong Ma 1, 5 Dhananjay Nawandar 3, 7 Elizabeth A. Barlow James C. Romero-Masters 4 Jillian Bristol Zhe Li 8 Ming-Han Tsai Henri-Jacques Delecluse and Shannon Kenney 2 Department of Oncology, School Medicine Public Health, University Wisconsin-Madison, Madison, Wisconsin, USA Medicine, 3 Cellular Molecular Biology, Pathology, Sanofi Pharmaceuticals, Cambridge, Massachusetts, Rocky Mountain Infectious Disease Specialists, Aurora, Colorado, Cancer...
EBV causes infectious mononucleosis and is associated with certain malignancies. nuclear antigen 1 (EBNA1) mediates genome replication, partition, transcription, essential for persistence of the viral in host cells. Here we demonstrate that Hsp90 inhibitors decrease EBNA1 expression translation, this effect requires Gly-Ala repeat domain EBNA1. induce death established, EBV-transformed lymphoblastoid cell lines at doses nontoxic to normal cells, substantially reversed when are stably...
ABSTRACT Epstein-Barr virus (EBV)-associated diseases of epithelial cells, including tumors that have latent infection, such as nasopharyngeal carcinoma (NPC), and oral hairy leukoplakia (OHL) lesions lytic frequently express the viral membrane protein 1 (LMP1). In lytically infected LMP1 expression is activated by BRLF1 (R) immediate early (IE) protein. However, mechanisms which normally regulated in cells remain poorly understood, its potential roles regulating reactivation are yet...
To develop an evidence-based clinical practice guideline (CPG) through a broad-based consensus process on best practices for chiropractic management of patients with chronic musculoskeletal (MSK) pain.
ABSTRACT All eight human herpesviruses have a conserved herpesvirus protein kinase (CHPK) that is important for the lytic phase of viral life cycle. In this study, we show heat shock 90 (Hsp90) interacts directly with each CHPKs, and demonstrate an Hsp90 inhibitor drug, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), decreases expression all CHPKs in transfected HeLa cells. 17-DMAG also endogenous Epstein-Barr virus (EBV PK, encoded by BGLF4 gene) lytically infected...
Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we examined importance for early-passage LCLs (EPL) mice, identified lytic EBV proteins that activate production compared viral cellular differences between early versus late passage (LPL). was required efficient EPL mice. The immediate-early (IE) proteins, BRLF1 BZLF1, each induced secretion...
Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 EBNA 3A/B/C latency genes the ability to transform B cells vitro. While most T1 EBV contain "prototype" form BZLF1 immediate-early promoter ("Zp-P"), all T2 "Zp-V3" variant, which contains an NFAT binding motif is activated much more strongly by B-cell receptor signalling. Whether lytic than unknown. Here we show (AG876 BL5) have protein expression...
The Epstein-Barr virus (EBV) BRRF1 lytic gene product (Na) is encoded within the same immediate-early region as BZLF1 (Z) and BRLF1(R) products, but its role during EBV infection has not been well defined. We previously showed that Na cooperates with R protein to induce expression in latently infected EBV-positive 293 cells, some EBV-negative cell lines it can activate Z promoter reporter assays. Here we show overexpression of alone sufficient several different epithelial (Hone-Akata,...
ABSTRACT The Epstein-Barr virus immediate-early protein, BZLF1 (Z), initiates the switch between latent and lytic infection plays an essential role in mediating viral replication. Z also inhibits expression of major receptor for tumor necrosis factor (TNF), TNFR1, thus repressing TNF cytokine signaling, but mechanism this effect is unknown. Here, we demonstrate that prevents both C/EBPα- C/EBPβ-mediated activation TNFR1 promoter (TNFR1p) by interacting directly with C/EBP family members. We...