A5045397139- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Ethics in Clinical Research
- Neonatal Health and Biochemistry
- Signaling Pathways in Disease
- Urological Disorders and Treatments
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Autopsy Techniques and Outcomes
Baylor College of Medicine
2019-2023
Texas Children's Hospital
2019-2023
Dan L Duncan Comprehensive Cancer Center
2021
Houston Methodist
2019
Methodist Hospital
2019
Abstract Loss of protein quality is a driving force aging 1 . The accumulation misfolded proteins represents vulnerability for long-lived cells, such as haematopoietic stem cells. How these which have the ability to reconstitute all lineages throughout life 2 , maintain their regenerative potential and avert effects poorly understood. Here, we determined content in progenitor cells identify prevalent chaperones that support proteome integrity. We identified Peptidyl-Prolyl Isomerase A (PPIA...
Summary After food ingestion, pancreatic cells secrete zymogen and hormone-containing granules to precisely control digestion blood glucose levels. Identifying regulators of this process is paramount combatting multiple diseases. Here we show that deletion the transcription factor nuclear IA (NFIA) leads hyperglycemia, hypoinsulinemia, hypolipidemia. Surprisingly, insulin digestive enzymes are produced in absence NFIA, however, they not secreted properly instead accumulate inside cells. In...
Abstract Purpose The use of postoperative prophylactic antibiotics in pediatric upper urinary tract reconstruction remains controversial. In this study, we examined whether low dose administered following pyeloplasty reduce the incidence febrile infections at our institution. As a secondary outcome, those patients with infection, additional analysis was performed to better quantify which patient population benefits most from antibiotics. Methods Institutional review board approval (IRB)...
Abstract Background: The use of postoperative prophylactic antibiotics in pediatric upper urinary tract reconstruction remains controversial. In this study, we elected to examine if post dismember pyeloplasty reduce the incidence clinically symptomatic infections (UTIs) our institution. As a secondary outcome, also which patient population benefits most from low dose antibiotics. Methods: Institutional review board approval (IRB) was obtained. A retrospective study performed patients who...
Abstract Purpose: The use of postoperative prophylactic antibiotics in pediatric upper urinary tract reconstruction remains controversial. In this study, we elected to examine if low dose (Abx) post dismember pyeloplasty reduce the incidence infections (UTIs) our institution. As a secondary outcome, patients who present with op febrile UTIs, additional analysis was performed better quantify which patient population benefits most from Abx. Methods: Institutional review board approval (IRB)...