A5016333981- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Fullerene Chemistry and Applications
- Surfactants and Colloidal Systems
- Spectroscopy and Quantum Chemical Studies
- Cardiac electrophysiology and arrhythmias
- Force Microscopy Techniques and Applications
- Carbon Nanotubes in Composites
- Advanced Data Storage Technologies
- Proteins in Food Systems
- Protein Interaction Studies and Fluorescence Analysis
- Photoreceptor and optogenetics research
- Field-Flow Fractionation Techniques
- Food Chemistry and Fat Analysis
- Advanced Thermodynamics and Statistical Mechanics
- Pickering emulsions and particle stabilization
- Mosquito-borne diseases and control
- Distributed and Parallel Computing Systems
- IoT and Edge/Fog Computing
- Edible Oils Quality and Analysis
- Polysaccharides Composition and Applications
- HIV/AIDS drug development and treatment
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
Kasetsart University
2012-2024
National Science and Technology Development Agency
2020-2024
National Electronics and Computer Technology Center
2020-2024
Thailand Center of Excellence in Physics
2021
University of Oxford
2015-2017
The influence of different oxidized lipids on lipid bilayers was investigated with 16 individual 1 μs atomistic molecular dynamics (MD) simulations. Binary mixtures 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) and its peroxide aldehyde products were performed at concentrations. In addition, an asymmetrical short chain lipid, 1-palmitoyl-2-decanoyl-sn-glycero-3-phosphatidylcholine (PDPC), used to compare the effects polar/apolar groups in tail bilayer. Although water...
Highlights•Mechanogating of TREK-2 involves movement from the down to up conformation•Simulations sample a wide range mechanosensitive K2P channel structures•Changes in pressure profile and state-dependent lipid interactions play key role•Lipid block inner pore does not mediate stretch activationSummaryThe two-pore domain (K2P) K+ channels (TREK-1, TREK-2, TRAAK) are important for mechanical thermal nociception. However, mechanisms underlying their gating by membrane remain controversial....
Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety mechanosensitive ion channels have evolved facilitate these responses, but the molecular mechanisms underlying their exquisite sensitivity different forces within membrane remains unclear. TREK-2 is mammalian two-pore domain (K2P) K+ channel important for mechanosensation, recent studies shown how increased tension favors more expanded conformation membrane. These complex stimuli, however, it uncertain...
Polyunsaturated lipids are major targets of free radicals forming oxidized through the lipid peroxidation process. Thus, play a significant role in cell membrane damage. Using atomistic molecular dynamics (MD) simulations to investigate bilayers, we examined effects NaCl on them. Lipid bilayer systems 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) and 4 oxidation products, namely, 9-tc-hydroperoxide linoleic acid, 13-tc-hydroperoxide 9-oxononanoic 12-oxo-9-didecadienoic acid...
Dengue is a potentially deadly tropical infectious disease transmitted by mosquito vector
This paper reviews our current understanding of how fullerene molecules interact with biological membranes. First, we discuss fullerenes permeate into Next, the putative mechanisms aggregation and dispersion within lipid bilayers are discussed along their potential toxic effect on Finally, trends in study fullerene-membrane interactions highlighted as well future challenges that need to be overcome further advance field.
Understanding the interactions between carbon nanoparticles (CNPs) and biological membranes is critically important for applications of CNPs in biomedicine toxicology. Due to complexity diversity systems, most molecular simulation studies have focused on single component bilayers. In this work, we performed coarse-grained dynamic (CGMD) simulations investigate behaviors fullerenes presence multiple lipid components plasma with varying fullerene concentrations. Our results reveal that can...
The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K+ responds to changes in membrane tension undergoing major structural change from its 'down' state the more expanded 'up' conformation. These are mostly restricted lower part protein within bilayer, but allosterically coupled primary gating mechanism located selectivity filter. However, any such filter also have...
Although spearmint oil (SMO) has various pharmacological properties, especially for cancer treatment, its low water solubility results in poor bioavailability. This limits application as a medicine. One possible solution is to the use of SMO form nanoemulsion, which already been shown have anticancer effects. However, mechanism nanoemulsion formation remains unclear. The objective this study was molecular dynamics (MD) clarifying with triglycerides (trilaurin, tripalmitin, and triolein)...
Abstract Carbon nanoparticles (CNPs) are attractive materials for a great number of applications but there serious concerns regarding their influence on health and environment. Here, our focus is the behavior fullerenes in lipid bilayers with varying saturations, chain lengths fullerene concentrations using coarse-grained molecular dynamics (CG-MD) simulations. Our findings show that saturation level key factor determining how behave where located inside bilayer. In saturated monounsaturated...