A5061750136- Hematopoietic Stem Cell Transplantation
- Oral health in cancer treatment
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Gut microbiota and health
- Growth Hormone and Insulin-like Growth Factors
- Hematological disorders and diagnostics
- Bone health and treatments
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cancer survivorship and care
- Clinical Nutrition and Gastroenterology
- Drug-Induced Hepatotoxicity and Protection
- Effects of Radiation Exposure
- Erythrocyte Function and Pathophysiology
Rigshospitalet
2017-2025
Copenhagen University Hospital
2023-2025
University of Copenhagen
2020-2023
ABSTRACT Diagnosing acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is challenging due to heterogeneity in interpreting current clinical criteria. Recently, the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria were introduced improve diagnostic consistency. In a study of 117 pediatric patients undergoing HSCT, modified Glucksberg and MAGIC retrospectively compared. The identified significantly more cases...
Liver toxicity is frequently seen in relation to allogeneic hematopoietic stem cell transplantation (HSCT), but pathogenesis and the risk factors are poorly understood. The purpose of this study was investigate associations between liver toxicity, gastrointestinal levels immune-regulating cytokines during early post-transplantation period. We prospectively included 81 children adults undergoing HSCT after myeloablative conditioning. Alanine aminotransferase (ALT), total bilirubin levels,...
Chemotherapy-induced mucositis increases the risk of blood stream infections (BSI) due to translocation bacteria across intestinal epithelium. Our study investigated if quantitative measures severity, including plasma citrulline (a marker functional enterocytes) and CCL20 (an immune homeostatic chemokine), could identify patients at BSI. A total 106 children with ALL undergoing induction treatment (NOPHO 2008) were included information regarding BSI episodes was collected from patients'...
Abstract Background Early‐onset osteoporosis is a frequent late effect after pediatric hematopoietic stem cell transplantation (HSCT). It remains unknown if physical training can improve bone formation in these patients, as the procedure may cause sustained dysregulation of bone‐forming osteoblast progenitor cells. Objective We aimed to explore resistance on remodeling long‐term survivors HSCT. Procedure In this prospective, controlled intervention study, we included seven HSCT and 15 age‐...
Abstract Severe intestinal mucositis (IM) increases the risk of bloodstream infections (BSI) and inflammatory toxicity during acute lymphoblastic leukaemia (ALL) induction treatment. However, implications IM in subsequent ALL therapy phases after achieving remission remain unknown. This study investigated relationship between (measured by plasma citrulline chemokine CCL20) development BSI systemic inflammation (reflected C‐reactive protein, CRP) children with high‐dose methotrexate (HDMTX)...
Delayed neutrophil recovery during acute lymphoblastic leukemia (ALL) treatment increases risk of infection and causes delay in chemotherapy. Emerging evidence implicates the gut microbiota reconstitution after We explored interplay between dynamics, including chemoattractants, 51 children with newly-diagnosed ALL. Daily absolute count (ANC), weekly plasma chemokines (CXCL1 CXCL8), granulocyte colony-stimulating factor (G-CSF), fecal samplings were monitored until day 29 ALL induction...
Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are challenged by cytotoxic effects of the conditioning regimen, resulting in tissue damage, systemic inflammation, and increased metabolic demands for amino acids to regenerate damaged tissues, reconstitute cells, establish antioxidant defenses. To date, few studies have addressed role plasma acid (PAA) levels during transplantation, it remains unknown if deficiency can aggravate treatment-related morbidity. We...
Although neutropenic fever is frequently observed during chemotherapy, only a minor proportion caused by blood stream infections (BSI). This study investigated measurements of neutrophil chemotaxis as risk markers for BSI in children with acute lymphoblastic leukemia (ALL).The chemokines CXCL1 and CXCL8 were measured weekly 106 ALL induction treatment. Information regarding episodes was collected from the patients' medical records.During treatment, 102 (96%) patients developed profound...
Abstract Despite chemotherapy-induced intestinal mucositis being a main risk factor for blood stream infections (BSIs), no studies have investigated severity to predict BSI at fever onset during acute leukemia treatment. This study prospectively evaluated in 85 children with leukemia, representing 242 febrile episodes (122 concurrent neutropenia) by measuring plasma levels of citrulline (reflecting enterocyte loss), regenerating islet-derived-protein 3α (REG3α, an antimicrobial peptide) and...
Allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute non-infectious toxicities, including sinusoidal obstruction syndrome (SOS), engraftment (ES) and capillary leak (CLS) among others. These complications are thought to be driven a dysfunctional vascular endothelium, but the pathophysiological mechanisms remain incompletely understood, diagnoses purely clinical diagnostic criteria that partly overlapping, limiting possibilities for progress in this field. There...
<title>Abstract</title> Prolonged neutrophil recovery during acute lymphoblastic leukemia (ALL) treatment increases infection risk and delays chemotherapy. Emerging evidence implicates the gut microbiota in reconstitution after We explored interplay between dynamics, including chemoattractants, 51 children with newly-diagnosed ALL. Daily absolute count (ANC), weekly plasma chemokines (CXCL1 CXCL8), granulocyte colony-stimulating factor (G-CSF), fecal samplings were monitored until day 29 ALL...
The treatment of childhood cancer is challenged by toxic side effects mainly due to chemotherapy-induced organ damage and infections, which are accompanied severe systemic inflammation. Insulin-like growth factor I (IGF-I) a key regulating in tissue repair. This study investigated associations between the circulating IGF-I levels chemotherapy-related toxicity pediatric acute lymphoblastic leukemia (ALL). In this prospective study, we included 114 patients (age: 1–17 years) with newly...
The aim of the study was to investigate whether high endogenous levels insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) were related a faster reconstitution different blood cell populations in early phase after allogeneic myeloablative haematopoietic stem transplantation (HSCT).We measured IGF-1 IGFBP-3 by chemiluminescence during first three weeks 35 adult patients undergoing HSCT calculated area under curve divided time (AUC/t) for each patient.Circulating...