A5038161566- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- GABA and Rice Research
- Alzheimer's disease research and treatments
- Lipid Membrane Structure and Behavior
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
Utrecht University
2021-2023
University College London
2021
Abstract Background Microglia are active modulators of Alzheimer’s disease but their role in relation to amyloid plaques and synaptic changes due rising beta is unclear. We add novel findings concerning these relationships investigate which our previously reported results from transgenic mice can be validated knock-in mice, overexpression other artefacts technology avoided. Methods App NL-F NL-G-F expressing humanised with mutations that cause familial were compared wild type throughout...
During the first two postnatal weeks, intraneuronal chloride concentrations in rodents gradually decrease, causing a shift from depolarizing to hyperpolarizing GABA responses. The is delayed rodent models for neurodevelopmental disorders and human patients, but impact of on developing brain remains obscure. Here we examine direct indirect consequences network development organotypic hippocampal cultures made 6- 7-d-old mice by treating 1 week with VU0463271, specific inhibitor exporter KCC2....
Abstract Intraneuronal chloride concentrations ([Cl − ] i ) decrease during development resulting in a shift from depolarizing to hyperpolarizing GABA responses via chloride-permeable A receptors. This plays pivotal role postnatal brain development, and can be strongly influenced by early life experience. Here, we assessed the applicability of recently developed fluorescent SuperClomeleon (SClm) sensor examine changes [Cl using two-photon microscopy slices. We used SClm mice both sexes...
Abstract During the first two postnatal weeks intraneuronal chloride concentrations in rodents gradually decrease, causing a shift from depolarizing to hyperpolarizing γ-aminobutyric acid (GABA) responses. GABAergic depolarization immature brain is crucial for formation and maturation of excitatory synapses, but when signaling becomes inhibitory it no longer promotes synapse formation. Here we examined role transporters developing hippocampal neurons using furosemide, an inhibitor importer...
Abstract Intraneuronal chloride concentrations ([Cl - ] i ) decrease during development resulting in a shift from depolarizing to hyperpolarizing y-aminobutyric acid (GABA) responses via chloride-permeable GABA A receptors. This plays pivotal role postnatal brain development, and can be strongly influenced by early life experience. Here, we assessed the applicability of recently developed fluorescent SuperClomeleon (SClm) sensor examine changes [Cl using two-photon microscopy slices. We used...
Abstract During the first two postnatal weeks intraneuronal chloride concentrations in rodents gradually decrease, causing a shift from depolarizing to hyperpolarizing γ-aminobutyric acid (GABA) responses. The GABA is delayed rodent models for neurodevelopmental disorders and human patients, but impact of on developing brain remain obscure. Here we examine direct indirect consequences network development organotypic hippocampal cultures made 6 7-day old mice by treating one week with...
Background Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due rising beta is unclear. We add novel findings concerning these relationships investigate which our previously reported results from transgenic mice can be validated knock-in mice, overexpression other artefacts technology avoided. Methods AppNL-F AppNL-G-F expressing humanised with mutations App that cause familial were compared wild type throughout life....