A5034238749- Asthma and respiratory diseases
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Systemic Lupus Erythematosus Research
- Erythrocyte Function and Pathophysiology
- Genomic variations and chromosomal abnormalities
- Bacterial Identification and Susceptibility Testing
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Inhalation and Respiratory Drug Delivery
- School Health and Nursing Education
- Protein Degradation and Inhibitors
- Endometrial and Cervical Cancer Treatments
University of California, Los Angeles
2018-2024
UCLA Health
2017-2020
Morehouse School of Medicine
2016-2017
Creative Research Enterprises (United States)
2017
The University of Western Australia
2005-2014
Government of Western Australia Department of Health
2007
Health and Human Development (2HD) Research Network
2002
Curtin University
1999
// Adriana Harbuzariu 1 , Antonio Rampoldi Danielle S Daley-Brown Pierre Candelaria Tia L Harmon Crystal C Lipsey Derrick J Beech 2 Alexander Quarshie 3 Gabriela Oprea Ilies 4 Ruben R Gonzalez-Perez Department of Microbiology, Biochemistry and Immunology, Morehouse School Medicine, Atlanta, GA, 30310 USA Surgery, Biomedical Informatics Program Master Science in Clinical Research Program, Center, GA 30310, Pathology Laboratory Emory University Grady Memorial Hospital, 30303 Correspondence to:...
The role of interleukin-10 (IL-10) in malaria remains poorly characterized. aims this study were to investigate (i) whether genetic variants the IL-10 gene influence production and (ii) as well genotypes haplotypes young children their mothers are associated with incidence clinical children. We genotyped three single nucleotide polymorphisms 240 from a longitudinal prospective cohort assessed by maternal peripheral blood mononuclear cells (PBMCs) cord (CBMCs). Clinical episodes Plasmodium...
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible -resistant Staphylococcus aureus. allowed a greater number of cells from strains to survive on high concentrations. also the frequency with which susceptible strain mutated become more resistant ciprofloxacin.
Abstract The transferrin receptor 1 (TfR1) is an attractive target for Ab-mediated cancer therapy. We previously developed a mouse/human chimeric IgG3 Ab (ch128.1) targeting human TfR1, which exhibits direct in vitro cytotoxicity against certain malignant B cells through TfR1 degradation and iron deprivation. ch128.1 also demonstrates exceptional antitumor activity the cell malignancy multiple myeloma (MM) xenograft models of SCID-Beige mice bearing either disseminated ARH-77 or KMS-11 early...
We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) four IgE response (IL4, IL13, IL4RA, STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma allergy in Karelian children.Karelian children (412 Finnish 446 Russian) were recruited assessed for a range allergic conditions, 24 single-nucleotide polymorphisms genotyped 15 genes.The genotype-phenotype relationships differed Russian...
Transferrin receptor 1 (TfR1), also known as CD71, is a transmembrane protein involved in the cellular uptake of iron and regulation cell growth. This expressed at low levels on variety normal cells, but upregulated cells with high rate proliferation, including malignant activated immune cells. Infection human immunodeficiency virus (HIV) leads to chronic activation B resulting expression TfR1, B-cell dysfunction, ultimately development acquired syndrome-related non-Hodgkin lymphoma...
The transferrin receptor 1 (TfR1) is a meaningful target for antibody-based cancer therapy given its overexpression on malignant cells and central role in pathology. We previously developed mouse/human chimeric IgG3 targeting human TfR1 (ch128.1), which exhibits significant antitumor activity against multiple myeloma (MM) xenograft models of SCID-Beige mice bearing disseminated ARH-77 or KMS-11 tumors. This observed early late disease stages tumors and, this model, the mechanism Fc-mediated,...
Abstract Five New World mammarenaviruses (NWMs) cause life-threatening hemorrhagic fever (HF). Cellular entry by these viruses is mediated human transferrin receptor 1 (hTfR1). Here, we demonstrate that an antibody (ch128.1/IgG1) which binds the apical domain of hTfR1, potently inhibits infection attenuated and pathogenic NWMs in vitro. Computational docking Fab crystal structure onto known hTfR1 shows overlapping receptor-binding region shared viral envelope glycoprotein GP1 subunit...
Genetic and environmental influences their interactions are central to asthma pathogenesis. This study aimed investigate the effects of different macro-environments on genotype-phenotype associations in two geographically separated populations with common ancestry.To accomplish this, unselected Inuit were recruited, one living Greenland (n = 618) other Denmark 739). Subjects genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly Gln27Glu. The resulting genetic data analysed relationships...
Objective. The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) the association with obesity were investigated in types I II endometrial cancer (EmCa). Additionally, involvement leptin-induced invasiveness EmCa cells was investigated. Methods. mRNAs proteins analyzed from African-American <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mfenced open="("...
Multiple myeloma (MM) is an incurable malignancy of plasma cells and the second most common hematologic in United States. Although antibodies clinical cancer therapy are generally IgG class, IgE class have attractive properties as therapeutics, such their high affinity for Fc receptors (FcεRs), low serum levels endogenous allowing less competition FcR occupancy, lack inhibitory FcRs. Importantly, FcεRs expressed on immune that elicit antibody-dependent cell-mediated cytotoxicity (ADCC),...
Abstract Epstein–Barr virus (EBV) is a human gammaherpesvirus associated with the development of hematopoietic cancers B-lymphocyte origin, including AIDS-related non-Hodgkin lymphoma (AIDS-NHL). Primary infection B-cells EBV results in their polyclonal activation and immortalization. The transferrin receptor 1 (TfR1), also known as CD71, important for iron uptake regulation cellular proliferation. TfR1 highly expressed proliferating cells, activated lymphocytes malignant cells. We developed...
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Abstract Infection with the human immunodeficiency virus (HIV) and development of acquired syndrome (AIDS) increases risk developing B-cell lymphomas. AIDS-related non-Hodgkin lymphoma (AIDS-NHL) remains a significant clinical problem in era effective combination anti-retroviral therapy. In fact, AIDS-NHL is currently most common malignancy developed countries, where NHL accounts for 23-30% all deaths. Transferrin receptor 1 (TfR1), also known as CD71, type II transmembrane homodimeric...
Abstract Multiple myeloma (MM) is a B-cell proliferative disorder of monoclonal malignant plasma cells. It the second most common hematologic malignancy in United States, after non-Hodgkin lymphoma (NHL). Clinical manifestations MM include osteolytic bone lesions, hypercalcemia, renal failure, anemia, recurrent infections, and neuropathy. Standard treatments for proteasome inhibitor bortezomib, as well lenalidomide, thalidomide analog with immunomodulatory antiangiogenic properties. Although...
Abstract Epstein-Barr virus (EBV) is a human herpesvirus that associated with malignancies of both B lymphocyte and epithelial cell origin. EBV the development approximately 1.5% all cancers worldwide, including AIDS-related non-Hodgkin lymphoma (AIDS-NHL), Hodgkin (HL), post-transplant lymphoproliferative disease (PTLD). Primary infection cells results in their polyclonal activation immortalization. The transferrin receptor 1 (TfR1), also known as CD71, important for iron uptake regulation...
Transferrin receptor 1 (TfR1) is a universal cancer marker and meaningful target for antibody-based immunotherapy. We previously developed mouse/human chimeric antibody (ch128.1/IgG1) specific the human TfR1 reported that treatment of SCID-Beige mice bearing disseminated multiple myeloma (MM) cells with ch128.1/IgG1 results in significant antitumor activity early-stage late-stage disease. Both bortezomib lenalidomide are Food Drug Administration (FDA) approved therapeutics used to treat MM...
Abstract Background: Triple Negative Breast Cancer (TNBC) is an aggressive cancer with poor prognosis and difficult to treat. Current standard therapy for the disease includes a combination of chemotherapeutic drugs: doxorubicin (DOX), paclitaxel (TAX), cyclophosphamide (CTX). These drugs are ineffective as they exhibit shortcomings several side effects. TNBC patients develop chemoresistance that may be enhanced by leptin, which affects survival, proliferation, angiogenesis. Our lab...