A5048412075- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Microfluidic and Bio-sensing Technologies
- Electrochemical Analysis and Applications
- Polyoxometalates: Synthesis and Applications
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Transition Metal Oxide Nanomaterials
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Bioinformatics and Genomic Networks
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Enzyme-mediated dye degradation
- Advanced biosensing and bioanalysis techniques
- Toxin Mechanisms and Immunotoxins
- Gene expression and cancer classification
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience and Neural Engineering
- Renal and related cancers
- Catalysis and Oxidation Reactions
- HER2/EGFR in Cancer Research
Sechenov University
2022-2024
Institute of Solid State Chemistry
2016-2023
BioClinicum (Russia)
2018-2022
Endocrinology Research Center
2020-2021
Ministry of Health of the Russian Federation
2019
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2016-2019
Russian Academy of Sciences
1989-2016
A N Bach Institute of Biochemistry
2011-2016
Federal Center Research Fundamentals of Biotechnology
2016
Moscow State University
2016
In 2021, the fifth edition of WHO classification tumors central nervous system (WHO CNS5) was published. Molecular features were directly incorporated into diagnostic decision tree, thus affecting both typing and staging tumor. It has changed traditional approach, based solely on histopathological classification. The Cancer Genome Atlas project (TCGA) is one main sources molecular information about gliomas, including clinically annotated transcriptomic genomic profiles. Although TCGA itself...
Individual gene expression and molecular pathway activation profiles were shown to be effective biomarkers in many cancers. Here, we used the human interactome model algorithmically build 7470 pathways centered around individual products. We assessed their associations with tumor type survival comparison previous generation of (3022 "classical" pathways) RNA transcripts or proteomic genes, for 8141 1117 samples, respectively. For all analytes data, respectively, found a total 7441 7343...
Introduction: Relapse of breast cancer is one the key obstacles to successful treatment. Previously we have shown that low expression ELOVL5 and IGFBP6 genes in tissue corresponded poor prognosis. participates directly elongation polyunsaturated fatty acids (PUFAs) are considered play an important role cell metabolism. Thus, this work studied changes lipid metabolism cells with reduced either or gene. Methods: MDA-MB-231 a stable knockdown gene were used study. Transcriptomic proteomic...
DNA repair can prevent mutations and cancer development, but it also restore damaged tumor cells after chemo radiation therapy. We performed RNA sequencing on 95 human pathological thyroid biosamples including 17 follicular adenomas, 23 cancers, 3 medullar 51 papillary cancers 1 poorly differentiated cancer. The gene expression profiles are annotated here with the clinical histological diagnoses and, for BRAF V600E mutation status. molecular pathway analysis showed strongly upregulated...
Data published during the last 15 years on intercalation of metal and n-alkylammonium ions, organic molecules organometallic complexes in vanadium(V) oxide xerogel are generalised described systematically. The possible mechanisms processes considered. possibility using hybrid materials electrochemical optical devices as precursors for preparation anhydrous nanotubular forms compounds is discussed. bibliography includes 159 references.
Previously, we have shown that the aggregation of RNA-level gene expression profiles into quantitative molecular pathway activation metrics results in lesser batch effects and better agreement between different experimental platforms. Here, investigate whether level data analysis provides any advantage when comparing transcriptomic proteomic data. We compare paired obtained for same human cancer biosamples The Cancer Genome Atlas (TCGA) NCI Clinical Proteomic Tumor Analysis Consortium...
The effect of the operational potential on stability electrochemical biosensors is particularly relevant in case peroxidase biosensors, because these enzymes can catalyze reduction hydrogen peroxide via either a high-potential redox cycle [involving Compound I, II, and Fe(III)] or low-potential Fe(III) Fe(II)]. Herein, it shown that recombinant tobacco immobilized graphite surface displays two well-separated electrocatalytic waves, associated with each catalytic cycles. While continuous...
This work is devoted to the study of magnetic properties and Electron Paramagnetic Resonance (EPR) spectroscopy TiO2:Fe nanoparticles doped with Al in different structural states. The sol-gel methods have been used obtain particles both crystalline (average size from 3 20 nm) X-ray amorphous electron paramagnetic resonance spectra samples aluminum besides a line g-factor ~2 exhibit small signal 4.3 Fe3+ ions rhombohedral distortions. fraction distortions increases increasing content. For...
The evolution of protein-coding genes has both structural and regulatory components. first can be assessed by measuring the ratio non-synonymous to synonymous nucleotide substitutions. second component measured as normalized proportion transposable elements that are used elements. For time, we characterized in parallel evolutionary profiles for 10,890 human 2972 molecular pathways. We observed a ~0.1 correlation between metrics at gene level, which appeared much higher (~0.4) pathway level....
Covalent immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-step protocol, in which surface carboxylic groups are first activated with the corresponding cross-coupling reagents and then reacted protein amine groups. Herein, it shown that modification above involving simultaneous incubation tobacco peroxidase pyrolytic graphite electrode produces higher more stable electrocatalytic currents than those obtained either physically adsorbed or...
Breast cancer (BC) is the leading cause of death from malignant neoplasms among women worldwide, and metastatic BC presents biggest problems for treatment. Previously, it was shown that lower expression
Drug bioavailability studies commonly employ in vitro barrier tissue models consisting of epithelial and endothelial cells. These experiments require that the cell quality be assessed regularly, which is usually performed using various labeled substrates and/or evaluation transepithelial (transendothelial) electrical resistance (TEER). This technique provides information on integrity monolayer, but not differentiation-induced changes morphology. The present work shows impedance spectroscopy...
Placenta is a highly specialized organ that necessary for successful gestation. Several models of the placental barrier are used to study how it functions, including transplacental transport xenobiotics. One these models, human choriocarcinoma cell line BeWo widely in vitro. Notably, cancerous cells form multilayer structures normally not found placenta. Here, we aim develop techniques suitable monitoring b30 culture. To assess state growing on membrane, use impedance spectroscopy, which...