A5070163836- Chromosomal and Genetic Variations
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Prion Diseases and Protein Misfolding
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Systemic Lupus Erythematosus Research
- Genetics and Neurodevelopmental Disorders
- RNA and protein synthesis mechanisms
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
Université Claude Bernard Lyon 1
2013-2025
HES-SO Genève
2012-2022
Hudson Institute
2022
Gènes, synapses et cognition
2015-2021
Centre de Référence Déficits Immunitaires Héréditaires
2019
Heinrich Heine University Düsseldorf
2017
Électricité de France (France)
2006-2013
bioMérieux (France)
1993-2009
Centre National de la Recherche Scientifique
1992-2009
Institut de Biologie et de Chimie des Protéines
2006-2008
The partial molecular characterization of multiple sclerosis (MS)-associated retrovirus (MSRV), a novel previously called LM7, is reported. MSRV has been isolated repeatedly from leptomeningeal, choroid plexus and Epstein–Barr virus-immortalized B cells MS patients. A strategy based on reverse transcriptase PCR with RNA-purified extracellular virions yielded an initial pol fragment which other regions the retroviral genome were subsequently obtained by sequence extension. MSRV-specific...
ABSTRACT The multiple sclerosis-associated retrovirus (MSRV) isolated from plasma of MS patients was found to be phylogenetically and experimentally related human endogenous retroviruses (HERVs). To characterize the MSRV-related HERV family test hypothesis a replication-competent HERV, we have investigated expression sequences in healthy tissues. transcripts restricted placenta led isolation overlapping cDNA clones library. These cDNAs spanned 7.6-kb region containing gag , pol env genes;...
Multiple sclerosis-associated retroviral element (MSRV) is a element, the sequence of which served to define W family human endogenous retroviruses. MSRV viral particles display proinflammatory activities both in vitro mononuclear cell cultures and vivo humanized SCID mice model. To understand molecular basis such properties, we have investigated inflammatory potential surface unit envelope protein (ENV-SU), fraction that poised naturally interact with host cells. We report this study ENV-SU...
The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation.The objective this study was to confirm specify association between HERV-W/MSRV (Env) expression MS.103 MS, 199 healthy controls (HC) with other neurological diseases (28), chronic infections (30) or autoimmunity were analysed an immunoassay detecting Env in serum. RNA DNA copy numbers peripheral blood...
Differentiation of oligodendroglial precursor cells is crucial for central nervous system remyelination and influenced by both extrinsic intrinsic factors. Recent studies showed that human endogenous retrovirus type W (HERV-W) contributes significantly to brain damage. In particular, its envelope protein ENV can mediate injury specific cell types the immune system. Here, we investigated whether affects differentiation.Immunostaining gene expression analyses were performed establish...
Epidemiological and genome-wide association studies of severe psychiatric disorders such as schizophrenia (SZ) bipolar disorder (BD), suggest complex interactions between multiple genetic elements environmental factors. The involvement Human Endogenous Retroviruses type 'W' family (HERV-W) has consistently been associated with SZ. HERV-W envelope gene (env) is activated by factors encodes a protein displaying inflammation neurotoxicity. present study addressed the molecular characteristics...
Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system (CNS) for which animal models have mainly addressed downstream immunopathology but not potential inducers autoimmunity. In absence pathogen known to cause neuroinflammation in MS, Mycobacterial lysate commonly used form complete Freund's adjuvant induce autoimmunity myelin proteins Experimental Allergic Encephalomyelitis (EAE), an model MS. The present study demonstrates that protein from human...
Significance There is a broad repertoire of immunomodulatory drugs that effectively treat the inflammatory aspects relapsing multiple sclerosis (MS). However, axonal degeneration, which occurs mainly in progressive MS, still not understood and cannot be treated pharmaceutically. As it major factor contributing to clinical disability represents an unmet need. A recently completed phase IIb study has demonstrated anti-pathogenic human endogenous retrovirus type W (pHERV-W) envelope protein...
Human endogenous retroviruses (HERVs) occupy a substantial fraction of the genome and impact cellular function with both beneficial deleterious consequences. The vast majority HERV sequences descend from ancient retroviral families no longer capable infection or genomic propagation. In fact, most are represented by full-length proviruses but solitary long terminal repeats (solo LTRs) that arose via non-allelic recombination events between two LTRs proviral insertion. Because LTR-LTR may...
Attempts to identify a causative agent of Multiple Sclerosis (MS) among environmental viruses have consistently failed suggesting that development MS is result from gene-environment interactions. A new pathogenic player within human genes, endogenous retrovirus (HERV) was identified cells, named MS-associated element (MSRV) and unveiled homologous multicopy HERVs (HERV-W). As independent studies revealed biological features HERV-W on immune-mediated inflammation remyelinating the present...
Patients with COVID-19 may develop abnormal inflammatory response, followed in some cases by severe disease and long-lasting syndromes. We show here that vitro exposure to SARS-CoV-2 activates the expression of human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) peripheral blood mononuclear cells from a subset healthy donors, ACE2 receptor infection-independent manner. Plasma and/or sera 221 patients different cohorts, infected successive variants including...
The human endogenous retrovirus type W (HERV-W) has been identified and repeatedly confirmed as human-specific pathogenic entity affecting many cell types in multiple sclerosis (MS). Our recent contributions revealed the encoded envelope (ENV) protein to disturb myelin repair by interfering with oligodendroglial precursor differentiation polarizing microglial cells toward an axon-damage phenotype. Indirect proof of ENV's antiregenerative degenerative activities gathered recently clinical...
The MSRV (multiple sclerosis-associated retrovirus) belongs to the human endogenous retrovirus HERV-W family. envelope protein originating from has been found in most patients with multiple sclerosis (MS). This (Env-ms) pro-inflammatory properties for several types of immune cells and could therefore play a role MS pathogenesis by promoting leukocyte diapedesis observed central nervous system patients. Our study aims analyze effects Env-ms on blood-brain barrier (BBB) at molecular functional...
Monoclonal antibodies (mAbs) play an increasing important role in the therapeutic armamentarium against multiple sclerosis (MS), inflammatory and degenerative disorder of central nervous system. Most mAbs currently developed for MS are immunomodulators blocking immune process. In contrast with targeting function, GNbAC1, a humanized IgG4 mAb, targets associated retrovirus envelope (MSRV-Env) protein, upstream factor pathophysiology MS. MSRV-Env protein is endogenous retroviral origin,...